COX10_YEAST
ID COX10_YEAST Reviewed; 462 AA.
AC P21592; D6W3J6;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Protoheme IX farnesyltransferase, mitochondrial;
DE EC=2.5.1.-;
DE AltName: Full=Heme O synthase;
DE Flags: Precursor;
GN Name=COX10; OrderedLocusNames=YPL172C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2167310; DOI=10.1016/s0021-9258(18)77289-x;
RA Nobrega M.P., Nobrega F.G., Tzagoloff A.;
RT "COX10 codes for a protein homologous to the ORF1 product of Paracoccus
RT denitrificans and is required for the synthesis of yeast cytochrome
RT oxidase.";
RL J. Biol. Chem. 265:14220-14226(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30.
RC STRAIN=RZ49-1;
RX PubMed=7836424; DOI=10.1074/jbc.270.5.1983;
RA Niino Y.S., Chakraborty S., Brown B.J., Massey V.;
RT "A new old yellow enzyme of Saccharomyces cerevisiae.";
RL J. Biol. Chem. 270:1983-1991(1995).
RN [5]
RP FUNCTION.
RX PubMed=8118433;
RA Tzagoloff A., Nobrega M., Gorman N., Sinclair P.;
RT "On the functions of the yeast COX10 and COX11 gene products.";
RL Biochem. Mol. Biol. Int. 31:593-598(1993).
CC -!- FUNCTION: Converts protoheme IX and farnesyl diphosphate to heme O.
CC {ECO:0000269|PubMed:8118433}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M55566; AAA34509.1; -; Genomic_DNA.
DR EMBL; Z73528; CAA97879.1; -; Genomic_DNA.
DR EMBL; L29279; AAA64523.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11262.1; -; Genomic_DNA.
DR PIR; A37812; COBY10.
DR RefSeq; NP_015153.1; NM_001183986.1.
DR AlphaFoldDB; P21592; -.
DR SMR; P21592; -.
DR BioGRID; 36011; 431.
DR DIP; DIP-3982N; -.
DR STRING; 4932.YPL172C; -.
DR PaxDb; P21592; -.
DR PRIDE; P21592; -.
DR EnsemblFungi; YPL172C_mRNA; YPL172C; YPL172C.
DR GeneID; 855931; -.
DR KEGG; sce:YPL172C; -.
DR SGD; S000006093; COX10.
DR VEuPathDB; FungiDB:YPL172C; -.
DR eggNOG; KOG1380; Eukaryota.
DR GeneTree; ENSGT00940000153771; -.
DR HOGENOM; CLU_029631_2_1_1; -.
DR InParanoid; P21592; -.
DR OMA; MGREPDF; -.
DR BioCyc; YEAST:G3O-34067-MON; -.
DR BRENDA; 2.5.1.141; 984.
DR Reactome; R-SCE-189451; Heme biosynthesis.
DR PRO; PR:P21592; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; P21592; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0004311; F:farnesyltranstransferase activity; IBA:GO_Central.
DR GO; GO:0008495; F:protoheme IX farnesyltransferase activity; ISS:SGD.
DR GO; GO:0006784; P:heme A biosynthetic process; IMP:SGD.
DR GO; GO:0006783; P:heme biosynthetic process; IBA:GO_Central.
DR CDD; cd13957; PT_UbiA_Cox10; 1.
DR Gene3D; 1.10.357.140; -; 1.
DR InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR InterPro; IPR016315; Protohaem_IX_farnesylTrfase_mt.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR InterPro; IPR044878; UbiA_sf.
DR PANTHER; PTHR43448; PTHR43448; 1.
DR Pfam; PF01040; UbiA; 1.
DR PIRSF; PIRSF001773; COX10; 1.
DR TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR PROSITE; PS00943; UBIA; 1.
PE 3: Inferred from homology;
KW Heme biosynthesis; Membrane; Mitochondrion; Reference proteome;
KW Transferase; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..30
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 31..462
FT /note="Protoheme IX farnesyltransferase, mitochondrial"
FT /id="PRO_0000035925"
FT TRANSMEM 141..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..453
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 462 AA; 52148 MW; A8535C6D1BE2674F CRC64;
MSYFPRTYAH LMRNVLAHNK GNIYLQIGTQ LHDTQIKIRF NGVRYISRNH GGKQQHINTA
PIEFTPNFGY GDRTSNCNKK VESTAMKTLR CTDDISTSSG SEATTDASTQ LPFNVKLVDP
MVRKSKRPSH AISEGLNMKT LKKKVIMPYL QLTKPRLTIL VMLSAICSYA LSPYPASVNE
LLCLTVGTTL CSGSANAINM GREPEFDRQM VRTQARPVVR GDVTPTQAFE FAALIGTLGV
SILYFGVNPT VAILGASNIA LYGWAYTSMK RKHIINTWLG ALVGMVPPLM GWAAASPLSH
PGSWCLAGLL FAWQFPHFNT LSHNIRNEYK NAGYVMTAWK NPLLNARVSL RYSILMFPLC
FGLSYFNITD WYYQIDSGLI NAWLTFWAFK FYWQQRINYS AKTLKDNVKF NKGLSVANIY
ARKTFMASVL HLPAILILAI IHKKGRWDWI YPGEAKRPQE RF
