ID   COX11_DICDI             Reviewed;         312 AA.
AC   Q54HM6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX11, mitochondrial;
DE   Flags: Precursor;
GN   Name=cox11; ORFNames=DDB_G0289353;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Exerts its effect at some terminal stage of cytochrome c
CC       oxidase synthesis, probably by being involved in the insertion of the
CC       copper B into subunit I. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}; Intermembrane side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COX11/CtaG family. {ECO:0000305}.
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DR   EMBL; AAFI02000139; EAL62763.1; -; Genomic_DNA.
DR   RefSeq; XP_636275.1; XM_631183.1.
DR   AlphaFoldDB; Q54HM6; -.
DR   SMR; Q54HM6; -.
DR   STRING; 44689.DDB0252815; -.
DR   PaxDb; Q54HM6; -.
DR   EnsemblProtists; EAL62763; EAL62763; DDB_G0289353.
DR   GeneID; 8627093; -.
DR   KEGG; ddi:DDB_G0289353; -.
DR   dictyBase; DDB_G0289353; cox11.
DR   eggNOG; KOG2540; Eukaryota.
DR   HOGENOM; CLU_892614_0_0_1; -.
DR   InParanoid; Q54HM6; -.
DR   OMA; HREYSTH; -.
DR   PhylomeDB; Q54HM6; -.
DR   PRO; PR:Q54HM6; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031304; C:intrinsic component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; ISS:dictyBase.
DR   GO; GO:0005507; F:copper ion binding; ISS:dictyBase.
DR   GO; GO:0009060; P:aerobic respiration; ISS:dictyBase.
DR   GO; GO:0065003; P:protein-containing complex assembly; ISS:dictyBase.
DR   Gene3D; 2.60.370.10; -; 1.
DR   HAMAP; MF_00155; CtaG; 1.
DR   InterPro; IPR023471; CtaG/Cox11_dom_sf.
DR   InterPro; IPR007533; Cyt_c_oxidase_assmbl_CtaG.
DR   Pfam; PF04442; CtaG_Cox11; 1.
DR   SUPFAM; SSF110111; SSF110111; 1.
PE   3: Inferred from homology;
KW   Copper; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..312
FT                   /note="Cytochrome c oxidase assembly protein COX11,
FT                   mitochondrial"
FT                   /id="PRO_0000320290"
FT   TOPO_DOM        ?..131
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..312
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REGION          79..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..101
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..116
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  35485 MW;  82F480D0827DA8D7 CRC64;
     MSRLFNNFLL KTNKNQFIQS FSTKSQINNN IFNNLIKNEK ISLPPPPFLS SSSPLSMNNI
     FNRNNKNLYT TNNFNYNKLQ FTTQSPNPTP TPTPTPTPTP TPNNNENNNN KNNNNNNFKE
     EQKKILQEKN KAIGLYVLIA IIGILGLSYA AVPLYRIFCR ATGYGGTTRD ADDFDVIRKR
     NLDRTVYPIK VTFSASTANK IPWTFKPTQS TIECLPGEPV LCFYRATNNT DTPIIGVATY
     NITPMKAGTY FTKIQCFCFD EQRINAHETI DMPVLFVIEP ELLDDKNMKG VSDITLSYTF
     FKSNDQGEYE EI