COX11_MOUSE
ID COX11_MOUSE Reviewed; 275 AA.
AC Q6P8I6; Q3UNX9;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Cytochrome c oxidase assembly protein COX11, mitochondrial;
DE Flags: Precursor;
GN Name=Cox11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Exerts its effect at some terminal stage of cytochrome c
CC oxidase synthesis, probably by being involved in the insertion of the
CC copper B into subunit I. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CNNM4/ACDP4. Interacts with RANBP2.
CC {ECO:0000250|UniProtKB:Q9Y6N1}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9Y6N1}; Single-pass membrane protein
CC {ECO:0000255}; Intermembrane side {ECO:0000250|UniProtKB:Q9Y6N1}.
CC -!- SIMILARITY: Belongs to the COX11/CtaG family. {ECO:0000305}.
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DR EMBL; AK143937; BAE25618.1; -; mRNA.
DR EMBL; AL646046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL672199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC061233; AAH61233.1; -; mRNA.
DR CCDS; CCDS25243.1; -.
DR RefSeq; NP_950173.1; NM_199008.2.
DR AlphaFoldDB; Q6P8I6; -.
DR SMR; Q6P8I6; -.
DR BioGRID; 213688; 1.
DR STRING; 10090.ENSMUSP00000020851; -.
DR PhosphoSitePlus; Q6P8I6; -.
DR EPD; Q6P8I6; -.
DR MaxQB; Q6P8I6; -.
DR PaxDb; Q6P8I6; -.
DR PeptideAtlas; Q6P8I6; -.
DR PRIDE; Q6P8I6; -.
DR ProteomicsDB; 277998; -.
DR Antibodypedia; 30833; 146 antibodies from 25 providers.
DR DNASU; 69802; -.
DR Ensembl; ENSMUST00000020851; ENSMUSP00000020851; ENSMUSG00000020544.
DR GeneID; 69802; -.
DR KEGG; mmu:69802; -.
DR UCSC; uc007kwz.1; mouse.
DR CTD; 1353; -.
DR MGI; MGI:1917052; Cox11.
DR VEuPathDB; HostDB:ENSMUSG00000020544; -.
DR eggNOG; KOG2540; Eukaryota.
DR GeneTree; ENSGT00390000007512; -.
DR HOGENOM; CLU_045000_1_0_1; -.
DR InParanoid; Q6P8I6; -.
DR OMA; NKLECFC; -.
DR OrthoDB; 1287401at2759; -.
DR PhylomeDB; Q6P8I6; -.
DR TreeFam; TF105072; -.
DR Reactome; R-MMU-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-MMU-611105; Respiratory electron transport.
DR Reactome; R-MMU-9707564; Cytoprotection by HMOX1.
DR BioGRID-ORCS; 69802; 21 hits in 75 CRISPR screens.
DR PRO; PR:Q6P8I6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q6P8I6; protein.
DR Bgee; ENSMUSG00000020544; Expressed in sternocleidomastoid and 221 other tissues.
DR ExpressionAtlas; Q6P8I6; baseline and differential.
DR Genevisible; Q6P8I6; MM.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0031304; C:intrinsic component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0055065; P:metal ion homeostasis; ISO:MGI.
DR GO; GO:0033132; P:negative regulation of glucokinase activity; IDA:MGI.
DR Gene3D; 2.60.370.10; -; 1.
DR HAMAP; MF_00155; CtaG; 1.
DR InterPro; IPR023471; CtaG/Cox11_dom_sf.
DR InterPro; IPR007533; Cyt_c_oxidase_assmbl_CtaG.
DR Pfam; PF04442; CtaG_Cox11; 1.
DR SUPFAM; SSF110111; SSF110111; 1.
PE 1: Evidence at protein level;
KW Copper; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..275
FT /note="Cytochrome c oxidase assembly protein COX11,
FT mitochondrial"
FT /id="PRO_0000006081"
FT TOPO_DOM ?..94
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6N1"
FT TRANSMEM 95..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..275
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6N1"
FT REGION 57..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 275 AA; 30849 MW; F51774C9382CE8F0 CRC64;
MGGLWCPGWR LVASCGRGWR QPGWSGRTVV NAELVLRPGW DGLGGAERGL RRLGTWKRPC
GVRGPATQPP RRPRSSNPFQ RAQEDEWRRR NKTVLTYVAA AAVGMLGASY AAVPLYRLYC
QTTGLGGSAV AGHSSDQIEN MVPVKDRVIK VTFNADVHAS LQWNFRPQQT EIYVVPGETA
LAFYKAKNPT DKPVIGISTY NVVPFEAGQY FNKIQCFCFE EQRLNPQEEV DMPVFFYIDP
EFAEDPRMVN VDLITLSYTF FEAKEGHKLP VPGYN
