COX11_PONAB
ID COX11_PONAB Reviewed; 277 AA.
AC Q5R7U6;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 2.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Cytochrome c oxidase assembly protein COX11, mitochondrial;
DE Flags: Precursor;
GN Name=COX11;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Exerts its effect at some terminal stage of cytochrome c
CC oxidase synthesis, probably by being involved in the insertion of the
CC copper B into subunit I. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CNNM4/ACDP4. Interacts with RANBP2.
CC {ECO:0000250|UniProtKB:Q9Y6N1}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9Y6N1}; Single-pass membrane protein
CC {ECO:0000255}; Intermembrane side {ECO:0000250|UniProtKB:Q9Y6N1}.
CC -!- SIMILARITY: Belongs to the COX11/CtaG family. {ECO:0000305}.
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DR EMBL; CR860013; CAH92164.1; ALT_TERM; Transcribed_RNA.
DR AlphaFoldDB; Q5R7U6; -.
DR SMR; Q5R7U6; -.
DR STRING; 9601.ENSPPYP00000009281; -.
DR eggNOG; KOG2540; Eukaryota.
DR InParanoid; Q5R7U6; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR Gene3D; 2.60.370.10; -; 1.
DR HAMAP; MF_00155; CtaG; 1.
DR InterPro; IPR023471; CtaG/Cox11_dom_sf.
DR InterPro; IPR007533; Cyt_c_oxidase_assmbl_CtaG.
DR Pfam; PF04442; CtaG_Cox11; 1.
DR SUPFAM; SSF110111; SSF110111; 1.
PE 3: Inferred from homology;
KW Copper; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..28
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 29..277
FT /note="Cytochrome c oxidase assembly protein COX11,
FT mitochondrial"
FT /id="PRO_0000042180"
FT TOPO_DOM 29..94
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6N1"
FT TRANSMEM 95..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..277
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6N1"
FT REGION 64..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 277 AA; 31455 MW; 38A4CC0E35FF051A CRC64;
MGGLWRPGWR RVAFCGWRWI HPGSPTRAAE RVEPFLRPEC SGTGGAGRGL RWLGTWKRCS
LGARHPALQP PRRHKNSNPF TRAQKEEWRR RNKTTLTYVA AVAVGMLGAS YAAVPLYRLY
CQTTGLGGSA VAGHASDKIE NMVPVKDRII KISFNADVHA SLQWNFRPQQ TEIYVVPGET
ALAFYRAKNP TDKPVIGIST YNIVPFEAGQ YFNKIQQCFC FEEQRLNPQE EVDMPVFFYI
DPEFAEDPRM IKVDLITLSY TFFEAKEGHK LPVPGYN