COX11_YEAST
ID COX11_YEAST Reviewed; 300 AA.
AC P19516; D6W3N5;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Cytochrome c oxidase assembly protein COX11, mitochondrial;
DE Flags: Precursor;
GN Name=COX11; OrderedLocusNames=YPL132W; ORFNames=LPI13W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-300.
RX PubMed=2167832; DOI=10.1002/j.1460-2075.1990.tb07463.x;
RA Tzagoloff A., Capitanio N., Nobrega M.P., Gatti D.;
RT "Cytochrome oxidase assembly in yeast requires the product of COX11, a
RT homolog of the P. denitrificans protein encoded by ORF3.";
RL EMBO J. 9:2759-2764(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 141-300.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1325447; DOI=10.1016/s0021-9258(19)37105-4;
RA Tang B., Nazar R.N.;
RT "Unbalanced regulation of the ribosomal 5 S RNA-binding protein in
RT Saccharomyces cerevisiae expressing mutant 5 S rRNAs.";
RL J. Biol. Chem. 267:17738-17742(1992).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RX PubMed=22984289; DOI=10.1074/mcp.m112.021105;
RA Voegtle F.N., Burkhart J.M., Rao S., Gerbeth C., Hinrichs J.,
RA Martinou J.C., Chacinska A., Sickmann A., Zahedi R.P., Meisinger C.;
RT "Intermembrane space proteome of yeast mitochondria.";
RL Mol. Cell. Proteomics 11:1840-1852(2012).
CC -!- FUNCTION: Exerts its effect at some terminal stage of cytochrome c
CC oxidase synthesis, probably by being involved in the insertion of the
CC copper B into subunit I. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Single-pass
CC membrane protein; Intermembrane side {ECO:0000269|PubMed:22984289}.
CC Note=Intrinsic component of the inner-membrane.
CC -!- SIMILARITY: Belongs to the COX11/CtaG family. {ECO:0000305}.
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DR EMBL; U43703; AAB68227.1; -; Genomic_DNA.
DR EMBL; X55731; CAA39263.1; -; Genomic_DNA.
DR EMBL; M94864; AAA35235.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11301.1; -; Genomic_DNA.
DR PIR; S69052; S69052.
DR RefSeq; NP_015193.1; NM_001183946.1.
DR AlphaFoldDB; P19516; -.
DR SMR; P19516; -.
DR BioGRID; 36049; 61.
DR DIP; DIP-7497N; -.
DR IntAct; P19516; 2.
DR MINT; P19516; -.
DR STRING; 4932.YPL132W; -.
DR TCDB; 3.D.4.8.1; the proton-translocating cytochrome oxidase (cox) superfamily.
DR MaxQB; P19516; -.
DR PaxDb; P19516; -.
DR PRIDE; P19516; -.
DR EnsemblFungi; YPL132W_mRNA; YPL132W; YPL132W.
DR GeneID; 855971; -.
DR KEGG; sce:YPL132W; -.
DR SGD; S000006053; COX11.
DR VEuPathDB; FungiDB:YPL132W; -.
DR eggNOG; KOG2540; Eukaryota.
DR GeneTree; ENSGT00390000007512; -.
DR HOGENOM; CLU_045000_0_1_1; -.
DR InParanoid; P19516; -.
DR OMA; YRIFCQS; -.
DR BioCyc; YEAST:G3O-34031-MON; -.
DR PRO; PR:P19516; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; P19516; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031304; C:intrinsic component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005740; C:mitochondrial envelope; IDA:SGD.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
DR GO; GO:0005761; C:mitochondrial ribosome; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0005507; F:copper ion binding; IDA:SGD.
DR GO; GO:0009060; P:aerobic respiration; IMP:SGD.
DR GO; GO:0065003; P:protein-containing complex assembly; IMP:SGD.
DR Gene3D; 2.60.370.10; -; 1.
DR HAMAP; MF_00155; CtaG; 1.
DR InterPro; IPR023471; CtaG/Cox11_dom_sf.
DR InterPro; IPR007533; Cyt_c_oxidase_assmbl_CtaG.
DR Pfam; PF04442; CtaG_Cox11; 1.
DR SUPFAM; SSF110111; SSF110111; 1.
PE 1: Evidence at protein level;
KW Copper; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..300
FT /note="Cytochrome c oxidase assembly protein COX11,
FT mitochondrial"
FT /id="PRO_0000006082"
FT TOPO_DOM ?..84
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..300
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT CONFLICT 24..31
FT /note="WLAPHALA -> MVGTSCAS (in Ref. 3; CAA39263)"
FT /evidence="ECO:0000305"
FT CONFLICT 146
FT /note="T -> S (in Ref. 3; CAA39263 and 4; AAA35235)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 300 AA; 34044 MW; A8EBE549C6ED5A23 CRC64;
MIRICPIVRS KVPLLGTFLR SDSWLAPHAL ALRRAICKNV ALRSYSVNSE QPKHTFDISK
LTRNEIQQLR ELKRARERKF KDRTVAFYFS SVAVLFLGLA YAAVPLYRAI CARTGFGGIP
ITDRRKFTDD KLIPVDTEKR IRISFTSEVS QILPWKFVPQ QREVYVLPGE TALAFYKAKN
YSDKDIIGMA TYSIAPGEAA QYFNKIQCFC FEEQKLAAGE EIDMPVFFFI DPDFASDPAM
RNIDDIILHY TFFRAHYGDG TAVSDSKKEP EMNADEKAAS LANAAILSPE VIDTRKDNSN
