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COX14_MOUSE
ID   COX14_MOUSE             Reviewed;          57 AA.
AC   Q8BH51;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX14;
GN   Name=Cox14;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo, Kidney, and Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Core component of the MITRAC (mitochondrial translation
CC       regulation assembly intermediate of cytochrome c oxidase complex)
CC       complex, that regulates cytochrome c oxidase assembly. Requires for
CC       coordination of the early steps of cytochrome c oxidase assembly with
CC       the synthesis of MT-CO1. {ECO:0000250|UniProtKB:Q96I36}.
CC   -!- SUBUNIT: Along with COA3, core component of the MITRAC (mitochondrial
CC       translation regulation assembly intermediate of cytochrome c oxidase
CC       complex) complex. {ECO:0000250|UniProtKB:Q96I36}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
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DR   EMBL; AK002816; BAC25008.1; -; mRNA.
DR   EMBL; AK004378; BAC25080.1; -; mRNA.
DR   EMBL; AK009401; BAC25256.1; -; mRNA.
DR   EMBL; BC059905; AAH59905.1; -; mRNA.
DR   EMBL; BC092142; AAH92142.1; -; mRNA.
DR   CCDS; CCDS37205.1; -.
DR   RefSeq; NP_899079.1; NM_183256.3.
DR   AlphaFoldDB; Q8BH51; -.
DR   STRING; 10090.ENSMUSP00000023761; -.
DR   PhosphoSitePlus; Q8BH51; -.
DR   jPOST; Q8BH51; -.
DR   PaxDb; Q8BH51; -.
DR   PeptideAtlas; Q8BH51; -.
DR   PRIDE; Q8BH51; -.
DR   ProteomicsDB; 285254; -.
DR   Antibodypedia; 49669; 11 antibodies from 6 providers.
DR   Ensembl; ENSMUST00000023761; ENSMUSP00000023761; ENSMUSG00000023020.
DR   GeneID; 66379; -.
DR   KEGG; mmu:66379; -.
DR   UCSC; uc007xqe.2; mouse.
DR   CTD; 84987; -.
DR   MGI; MGI:1913629; Cox14.
DR   VEuPathDB; HostDB:ENSMUSG00000023020; -.
DR   eggNOG; ENOG502SCZ6; Eukaryota.
DR   GeneTree; ENSGT00390000002190; -.
DR   HOGENOM; CLU_209431_0_0_1; -.
DR   InParanoid; Q8BH51; -.
DR   OMA; VYHYFQR; -.
DR   OrthoDB; 1641370at2759; -.
DR   PhylomeDB; Q8BH51; -.
DR   TreeFam; TF338398; -.
DR   Reactome; R-MMU-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-MMU-611105; Respiratory electron transport.
DR   Reactome; R-MMU-9707564; Cytoprotection by HMOX1.
DR   BioGRID-ORCS; 66379; 4 hits in 68 CRISPR screens.
DR   ChiTaRS; Cox14; mouse.
DR   PRO; PR:Q8BH51; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q8BH51; protein.
DR   Bgee; ENSMUSG00000023020; Expressed in extra-ocular muscle and 245 other tissues.
DR   Genevisible; Q8BH51; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR   InterPro; IPR029208; COX14.
DR   PANTHER; PTHR36684; PTHR36684; 1.
DR   Pfam; PF14880; COX14; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..57
FT                   /note="Cytochrome c oxidase assembly protein COX14"
FT                   /id="PRO_0000263678"
FT   TRANSMEM        15..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   57 AA;  6380 MW;  4BEE2BF615B8FA68 CRC64;
     MPSAKQLADI GYKTFSASMM LLTVYGGYLC SVRAYRYLQL RSARRQAAEE QKTSGVL
 
 
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