ID   COX15_ARATH             Reviewed;         457 AA.
AC   Q9FKT8;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX15;
GN   Name=COX15; OrderedLocusNames=At5g56090; ORFNames=MDA7_15;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA   Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT   features of the regions of 1,381,565 bp covered by twenty one physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:131-145(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: May be involved in the biosynthesis of heme A. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COX15/CtaA family. {ECO:0000305}.
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DR   EMBL; AB011476; BAB09291.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED96720.1; -; Genomic_DNA.
DR   EMBL; AK117496; BAC42159.1; -; mRNA.
DR   EMBL; BT004976; AAO50509.1; -; mRNA.
DR   RefSeq; NP_200420.1; NM_124991.4.
DR   AlphaFoldDB; Q9FKT8; -.
DR   SMR; Q9FKT8; -.
DR   STRING; 3702.AT5G56090.1; -.
DR   PaxDb; Q9FKT8; -.
DR   PRIDE; Q9FKT8; -.
DR   ProteomicsDB; 241112; -.
DR   EnsemblPlants; AT5G56090.1; AT5G56090.1; AT5G56090.
DR   GeneID; 835708; -.
DR   Gramene; AT5G56090.1; AT5G56090.1; AT5G56090.
DR   KEGG; ath:AT5G56090; -.
DR   Araport; AT5G56090; -.
DR   TAIR; locus:2161785; AT5G56090.
DR   eggNOG; KOG2725; Eukaryota.
DR   HOGENOM; CLU_017627_0_0_1; -.
DR   InParanoid; Q9FKT8; -.
DR   OMA; YWWEWGH; -.
DR   OrthoDB; 1181324at2759; -.
DR   PhylomeDB; Q9FKT8; -.
DR   PRO; PR:Q9FKT8; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FKT8; baseline and differential.
DR   Genevisible; Q9FKT8; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR   GO; GO:0016653; F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor; IBA:GO_Central.
DR   GO; GO:0006784; P:heme A biosynthetic process; IBA:GO_Central.
DR   HAMAP; MF_01665; HemeA_synth_type2; 1.
DR   InterPro; IPR003780; COX15/CtaA_fam.
DR   InterPro; IPR023754; HemeA_Synthase_type2.
DR   PANTHER; PTHR23289; PTHR23289; 1.
DR   Pfam; PF02628; COX15-CtaA; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..457
FT                   /note="Cytochrome c oxidase assembly protein COX15"
FT                   /id="PRO_0000412566"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   457 AA;  50127 MW;  6E7A0DE6457E2D1E CRC64;
     MFRAVGSALK RNKEAFNGIA RGFTTSSHRV FTSNITAASV TSASSSPLAG NSFYGLRSLL
     KGQNASMFRR MSTVASISSE SKEGLKLLVT GGPQAQKWVG IWLFGSAAWV FSMVVLGGVT
     RLTRSGLSMT DWKFTGEFPP LSDEAWAKEF EKYKQSPEYK RVNKGMNLED FKFIYWMEYA
     HRMWGRGLGI MFALPFSYFL RKGYITLRLG VQLSGLFALG AGQGFIGWWM VKSGLEEPPS
     EYSQPRVSPY RLAAHLTSAF AIYCGLFWTA LSVVMPEPPA ESLAWVRGAA KVKKLALPVS
     LIVGITAISG AFVAGNDAGR AFNTFPKMGD TWIPDNIFEM KPLLRNFFEN TATVQLDHRL
     LATTTLIAIG TMWWFTRKLD IHPAVKALIG STVGMTAVQV TLGVSTLLSY VPVSLGSAHQ
     AGALTLLTLM LLLNHTLRRP SPSLLKSLPQ VAKSNFS