ID   COX15_BOVIN             Reviewed;         413 AA.
AC   Q08DG6;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX15 homolog;
GN   Name=COX15;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the biosynthesis of heme A.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the COX15/CtaA family. {ECO:0000305}.
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DR   EMBL; BC123760; AAI23761.1; -; mRNA.
DR   RefSeq; NP_001070329.1; NM_001076861.1.
DR   AlphaFoldDB; Q08DG6; -.
DR   SMR; Q08DG6; -.
DR   STRING; 9913.ENSBTAP00000055003; -.
DR   PaxDb; Q08DG6; -.
DR   PRIDE; Q08DG6; -.
DR   Ensembl; ENSBTAT00000064176; ENSBTAP00000055003; ENSBTAG00000045703.
DR   GeneID; 517811; -.
DR   KEGG; bta:517811; -.
DR   CTD; 1355; -.
DR   VEuPathDB; HostDB:ENSBTAG00000045703; -.
DR   VGNC; VGNC:27629; COX15.
DR   eggNOG; KOG2725; Eukaryota.
DR   GeneTree; ENSGT00390000002223; -.
DR   HOGENOM; CLU_017627_0_1_1; -.
DR   InParanoid; Q08DG6; -.
DR   OMA; YWWEWGH; -.
DR   OrthoDB; 1181324at2759; -.
DR   TreeFam; TF105073; -.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000045703; Expressed in cardiac ventricle and 105 other tissues.
DR   ExpressionAtlas; Q08DG6; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0016653; F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor; IBA:GO_Central.
DR   GO; GO:0006784; P:heme A biosynthetic process; IBA:GO_Central.
DR   HAMAP; MF_01665; HemeA_synth_type2; 1.
DR   InterPro; IPR003780; COX15/CtaA_fam.
DR   InterPro; IPR023754; HemeA_Synthase_type2.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   PANTHER; PTHR23289; PTHR23289; 1.
DR   Pfam; PF02628; COX15-CtaA; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..413
FT                   /note="Cytochrome c oxidase assembly protein COX15 homolog"
FT                   /id="PRO_0000274486"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        385..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   413 AA;  46126 MW;  A5E1CB2F19BF559B CRC64;
     MQRLLFTPLT AFLGSPCLRL LVPRVAPRTQ CGCSCGIRRP LRPGQYSTIS DVALQPGRST
     VSLPSKAAER VVGRWLLVCS GTVAGAVILG GVTRLTESGL SMVDWHLIKE MKPPTSKEEW
     EAEFQKYQQF PEFKILNHDM TLAEFKFIWY MEYSHRMWGR LVGLAYILPA AYFWKKGWLT
     RGLKGRVLAL CGLVCFQGLL GWYMVKSGLE EKPDSHDIPR VSQYRLAAHL GSALVLYCAS
     LWTSLSLLLP QHKLTETRQL LRLRRFAHGT AGLVFLTALS GAFVAGLDAG LVYNSFPKMG
     ESWIPEDLFT FSPLLRNVFE NPTMVQFDHR VLGIASVTAV TVLYFLSRRI PLPRRTKIAA
     TTLLALAYTQ VGLGISTLLM YVPTPLAATH QSGSLALLSV ALWLMNELRR VPK