COX15_MOUSE
ID COX15_MOUSE Reviewed; 413 AA.
AC Q8BJ03; Q3URB2; Q8VDN0; Q921K5;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Cytochrome c oxidase assembly protein COX15 homolog;
GN Name=Cox15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Head, and Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in the biosynthesis of heme A. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BJ03-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BJ03-2; Sequence=VSP_011282;
CC -!- SIMILARITY: Belongs to the COX15/CtaA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH21498.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK048099; BAC33241.1; -; mRNA.
DR EMBL; AK141631; BAE24776.1; -; mRNA.
DR EMBL; BC011509; AAH11509.1; -; mRNA.
DR EMBL; BC021498; AAH21498.1; ALT_INIT; mRNA.
DR CCDS; CCDS29836.1; -. [Q8BJ03-1]
DR RefSeq; NP_659123.2; NM_144874.4. [Q8BJ03-1]
DR AlphaFoldDB; Q8BJ03; -.
DR SMR; Q8BJ03; -.
DR BioGRID; 230478; 2.
DR IntAct; Q8BJ03; 37.
DR STRING; 10090.ENSMUSP00000041820; -.
DR PhosphoSitePlus; Q8BJ03; -.
DR EPD; Q8BJ03; -.
DR MaxQB; Q8BJ03; -.
DR PaxDb; Q8BJ03; -.
DR PeptideAtlas; Q8BJ03; -.
DR PRIDE; Q8BJ03; -.
DR ProteomicsDB; 283793; -. [Q8BJ03-1]
DR ProteomicsDB; 283794; -. [Q8BJ03-2]
DR Antibodypedia; 17500; 179 antibodies from 28 providers.
DR DNASU; 226139; -.
DR Ensembl; ENSMUST00000045562; ENSMUSP00000041820; ENSMUSG00000040018. [Q8BJ03-1]
DR GeneID; 226139; -.
DR KEGG; mmu:226139; -.
DR UCSC; uc008hot.2; mouse. [Q8BJ03-1]
DR CTD; 1355; -.
DR MGI; MGI:1920112; Cox15.
DR VEuPathDB; HostDB:ENSMUSG00000040018; -.
DR eggNOG; KOG2725; Eukaryota.
DR GeneTree; ENSGT00390000002223; -.
DR HOGENOM; CLU_017627_0_1_1; -.
DR InParanoid; Q8BJ03; -.
DR OMA; YWWEWGH; -.
DR OrthoDB; 1181324at2759; -.
DR PhylomeDB; Q8BJ03; -.
DR TreeFam; TF105073; -.
DR Reactome; R-MMU-189451; Heme biosynthesis.
DR BioGRID-ORCS; 226139; 18 hits in 74 CRISPR screens.
DR ChiTaRS; Cox15; mouse.
DR PRO; PR:Q8BJ03; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8BJ03; protein.
DR Bgee; ENSMUSG00000040018; Expressed in epithelium of small intestine and 243 other tissues.
DR Genevisible; Q8BJ03; MM.
DR GO; GO:0070069; C:cytochrome complex; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; HDA:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0060090; F:molecular adaptor activity; ISO:MGI.
DR GO; GO:0016653; F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor; IBA:GO_Central.
DR GO; GO:0006784; P:heme A biosynthetic process; ISO:MGI.
DR GO; GO:1902600; P:proton transmembrane transport; ISO:MGI.
DR GO; GO:0008535; P:respiratory chain complex IV assembly; ISO:MGI.
DR HAMAP; MF_01665; HemeA_synth_type2; 1.
DR InterPro; IPR003780; COX15/CtaA_fam.
DR InterPro; IPR023754; HemeA_Synthase_type2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR PANTHER; PTHR23289; PTHR23289; 1.
DR Pfam; PF02628; COX15-CtaA; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Mitochondrion; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..413
FT /note="Cytochrome c oxidase assembly protein COX15 homolog"
FT /id="PRO_0000183932"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 391..413
FT /note="QSGSLALLSGALWLMNELRRVPK -> THTHTP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_011282"
SQ SEQUENCE 413 AA; 45853 MW; 089D0EA76078C1EA CRC64;
MQRLLLPSLR ALTGSRNVGL LVPRVASRTQ CGSSCGSQRP LRPGQYSTIT EVALQSGKGT
VSLPSRAAER AVGRWLLVCS GTVAGAVILG GVTRLTESGL SMVDWHLIKE MKPPTSQEEW
EAEFQKYQQF PEFKILNHDM TLAEFKFIWY MEYSHRMWGR AVGLAYILPA AYFWRKGWLN
RGMKGRVLAL CGLVCFQGLL GWYMVKSGLE EKPESYDIPR VSQYRLAAHL GSALVLYCAS
LWTSLSLLLP QHKLPETRQL LWLRRFAGGT AGLVFLTALS GAFVAGLDAG LVYNSFPKMG
ESWIPEDLLT FSPVLKNVFE NPTMVQFDHR LLGVTSVTAI TVLYFLSRRI PLPRRTKMAA
VTLLALAYAQ VALGISTLLM YVPTPLAATH QSGSLALLSG ALWLMNELRR VPK
