ID   COX16_BOVIN             Reviewed;         107 AA.
AC   Q2NKS2;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial {ECO:0000305};
GN   Name=COX16 {ECO:0000250|UniProtKB:Q9P0S2};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the assembly of the mitochondrial respiratory
CC       chain complex IV (CIV), also known as cytochrome c oxidase. Promotes
CC       the insertion of copper into the active site of cytochrome c oxidase
CC       subunit II (MT-CO2/COX2). Interacts specifically with newly synthesized
CC       MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2
CC       and COA6. Probably facilitates MT-CO2/COX2 association with the MITRAC
CC       assembly intermediate containing MT-CO1/COX1, thereby participating in
CC       merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines.
CC       {ECO:0000250|UniProtKB:Q9P0S2}.
CC   -!- SUBUNIT: Associates with the MITRAC complex. Interacts with MT-CO2/COX;
CC       specifically interacts with newly synthesized MT-CO2/COX. Interacts
CC       with SCO1, SCO2 and COA6. {ECO:0000250|UniProtKB:Q9P0S2}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9P0S2}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9P0S2}.
CC   -!- SIMILARITY: Belongs to the COX16 family. {ECO:0000305}.
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DR   EMBL; BC111674; AAI11675.1; -; mRNA.
DR   RefSeq; NP_001040033.1; NM_001046568.1.
DR   AlphaFoldDB; Q2NKS2; -.
DR   STRING; 9913.ENSBTAP00000020832; -.
DR   PaxDb; Q2NKS2; -.
DR   PRIDE; Q2NKS2; -.
DR   Ensembl; ENSBTAT00000020832; ENSBTAP00000020832; ENSBTAG00000030595.
DR   GeneID; 615979; -.
DR   KEGG; bta:615979; -.
DR   CTD; 51241; -.
DR   VEuPathDB; HostDB:ENSBTAG00000030595; -.
DR   VGNC; VGNC:27630; COX16.
DR   eggNOG; ENOG502S3RD; Eukaryota.
DR   GeneTree; ENSGT00520000055955; -.
DR   HOGENOM; CLU_163592_0_0_1; -.
DR   InParanoid; Q2NKS2; -.
DR   OMA; RTMTFGV; -.
DR   TreeFam; TF324420; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000030595; Expressed in oocyte and 106 other tissues.
DR   ExpressionAtlas; Q2NKS2; baseline and differential.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR   InterPro; IPR020164; Cyt_c_Oxase_assmbl_COX16.
DR   Pfam; PF14138; COX16; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..107
FT                   /note="Cytochrome c oxidase assembly protein COX16 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000355116"
FT   TOPO_DOM        1..14
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P0S2"
FT   TRANSMEM        15..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..107
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P0S2"
FT   REGION          80..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   107 AA;  12518 MW;  433EA1CF7E549801 CRC64;
     MFGYAVRRAL RKSKTLRYGV PMLLLIVGGS FGLREFSQIR YDAVKIKIDP ELEKKLKMNK
     VSLESEYEKI KDSTFDDWKN IRGPRPWEDP DLLQGRNPEI LKTNKTT