ID   COX16_CAEEL             Reviewed;         115 AA.
AC   A0A1N7SYS3;
DT   28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial {ECO:0000305};
GN   Name=cox-16 {ECO:0000312|WormBase:C24G6.13a};
GN   ORFNames=C24G6.13 {ECO:0000312|WormBase:C24G6.13a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION.
RX   PubMed=29355485; DOI=10.1016/j.bbabio.2018.01.004;
RA   Cerqua C., Morbidoni V., Desbats M.A., Doimo M., Frasson C., Sacconi S.,
RA   Baldoin M.C., Sartori G., Basso G., Salviati L., Trevisson E.;
RT   "COX16 is required for assembly of cytochrome c oxidase in human cells and
RT   is involved in copper delivery to COX2.";
RL   Biochim. Biophys. Acta 1859:244-252(2018).
CC   -!- FUNCTION: Required for the assembly of the mitochondrial respiratory
CC       chain complex IV (CIV), also known as cytochrome c oxidase.
CC       {ECO:0000269|PubMed:29355485}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9P0S2}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9P0S2}.
CC   -!- SIMILARITY: Belongs to the COX16 family. {ECO:0000305}.
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DR   EMBL; BX284605; SIT60445.1; -; Genomic_DNA.
DR   RefSeq; NP_001335555.1; NM_001348574.1.
DR   AlphaFoldDB; A0A1N7SYS3; -.
DR   SMR; A0A1N7SYS3; -.
DR   EnsemblMetazoa; C24G6.13a.1; C24G6.13a.1; WBGene00302991.
DR   EnsemblMetazoa; C24G6.13a.2; C24G6.13a.2; WBGene00302991.
DR   WormBase; C24G6.13a; CE51852; WBGene00302991; cox-16.
DR   PRO; PR:A0A1N7SYS3; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00302991; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; A0A1N7SYS3; baseline and differential.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IMP:UniProtKB.
DR   InterPro; IPR020164; Cyt_c_Oxase_assmbl_COX16.
DR   Pfam; PF14138; COX16; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..115
FT                   /note="Cytochrome c oxidase assembly protein COX16 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000443803"
FT   TOPO_DOM        1..6
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P0S2"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..115
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P0S2"
SQ   SEQUENCE   115 AA;  13522 MW;  472382A9C8BDB773 CRC64;
     MSRLKFVRVG LPFFAIVLGS AYGLHFFQQV RFDFRKIKQE DDNLELLRSD LTRSGLRLRE
     GVTVESVYKE VAELDTDNWE NIRGPRDTED LTDYNLIKKQ QQEASRKVRE LKSNV