ID   COX16_CANAL             Reviewed;         128 AA.
AC   Q5ACH7; A0A1D8PUB2;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX16, mitochondrial;
DE   Flags: Precursor;
GN   Name=COX16; OrderedLocusNames=CAALFM_CR10760CA; ORFNames=CaO19.7665;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Required for the assembly of the mitochondrial respiratory
CC       chain complex IV (CIV), also known as cytochrome c oxidase. May
CC       participate in merging the COX1 and COX2 assembly lines.
CC       {ECO:0000250|UniProtKB:P47081}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P47081}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P47081}.
CC   -!- SIMILARITY: Belongs to the COX16 family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW31724.1; -; Genomic_DNA.
DR   RefSeq; XP_719424.1; XM_714331.1.
DR   AlphaFoldDB; Q5ACH7; -.
DR   SMR; Q5ACH7; -.
DR   STRING; 237561.Q5ACH7; -.
DR   GeneID; 3638943; -.
DR   KEGG; cal:CAALFM_CR10760CA; -.
DR   CGD; CAL0000184804; orf19.7665.
DR   VEuPathDB; FungiDB:CR_10760C_A; -.
DR   eggNOG; ENOG502S9GT; Eukaryota.
DR   HOGENOM; CLU_131611_1_0_1; -.
DR   InParanoid; Q5ACH7; -.
DR   OMA; FMLTPAT; -.
DR   OrthoDB; 1550606at2759; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IBA:GO_Central.
DR   InterPro; IPR020164; Cyt_c_Oxase_assmbl_COX16.
DR   Pfam; PF14138; COX16; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..128
FT                   /note="Cytochrome c oxidase assembly protein COX16,
FT                   mitochondrial"
FT                   /id="PRO_0000280642"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   128 AA;  15377 MW;  C684D71787F45775 CRC64;
     MSYSGNRVFR GKKEQEAYDK TLAGRYVKLV KKNHFLFFGL PFLVSIVAGS IYLQKFTSVK
     WEKYDEKYQQ LGEEEMLNLI ENKRTVDKKN DYYRLQGLLN DHTNQVADDY EIVRVQRRKE
     DEPVWDRQ