ID   COX16_CRYNJ             Reviewed;         130 AA.
AC   P0CM84; Q55NR3; Q5KC48;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX16, mitochondrial;
DE   Flags: Precursor;
GN   Name=COX16; OrderedLocusNames=CNI00260;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for the assembly of the mitochondrial respiratory
CC       chain complex IV (CIV), also known as cytochrome c oxidase. May
CC       participate in merging the COX1 and COX2 assembly lines.
CC       {ECO:0000250|UniProtKB:P47081}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P47081}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P47081}.
CC   -!- SIMILARITY: Belongs to the COX16 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW45421.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017349; AAW45421.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_572728.1; XM_572728.1.
DR   AlphaFoldDB; P0CM84; -.
DR   STRING; 214684.P0CM84; -.
DR   GeneID; 3259696; -.
DR   KEGG; cne:CNI00260; -.
DR   InParanoid; P0CM84; -.
DR   OrthoDB; 1550606at2759; -.
DR   Proteomes; UP000002149; Chromosome 9.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IBA:GO_Central.
DR   InterPro; IPR020164; Cyt_c_Oxase_assmbl_COX16.
DR   Pfam; PF14138; COX16; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..23
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..130
FT                   /note="Cytochrome c oxidase assembly protein COX16,
FT                   mitochondrial"
FT                   /id="PRO_0000280645"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          106..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   130 AA;  14887 MW;  4338D7D180E52EC5 CRC64;
     MPPFATRPLN STKSHPIFAQ IRRHPFILFG IPFIGIIVGS SFALQAFTQT RYDYQETKVK
     SVGKEEELGM KSGRRKIDLK EEYYFSMASV SQDDYEPVRV PRPVGVPEWG GGRSGEEAPM
     KGYRKEDRWV