ID   COX16_PARBD             Reviewed;         135 AA.
AC   Q52ZA1; C1G0A4;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX16, mitochondrial;
DE   Flags: Precursor;
GN   Name=COX16; ORFNames=PADG_00294;
OS   Paracoccidioides brasiliensis (strain Pb18).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC   STRAIN=Pb18;
RX   PubMed=18672058; DOI=10.1016/j.mycres.2008.07.001;
RA   Bandeira S.C.B., Nobrega M.P.;
RT   "Characterization of Paracoccidioides brasiliensis COX9, COX12, and COX16
RT   respiratory genes.";
RL   Mycol. Res. 112:1414-1420(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pb18;
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- FUNCTION: Required for the assembly of the mitochondrial respiratory
CC       chain complex IV (CIV), also known as cytochrome c oxidase. May
CC       participate in merging the COX1 and COX2 assembly lines.
CC       {ECO:0000250|UniProtKB:P47081}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P47081}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P47081}.
CC   -!- INDUCTION: Slightly induced during the mycelium to yeast transition.
CC       {ECO:0000269|PubMed:18672058}.
CC   -!- SIMILARITY: Belongs to the COX16 family. {ECO:0000305}.
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DR   EMBL; AY842443; AAX40578.1; -; mRNA.
DR   EMBL; KN275957; EEH44005.1; -; Genomic_DNA.
DR   RefSeq; XP_010756289.1; XM_010757987.1.
DR   AlphaFoldDB; Q52ZA1; -.
DR   STRING; 121759.XP_010756289.1; -.
DR   EnsemblFungi; EEH44005; EEH44005; PADG_00294.
DR   GeneID; 22580153; -.
DR   KEGG; pbn:PADG_00294; -.
DR   VEuPathDB; FungiDB:PADG_00294; -.
DR   eggNOG; ENOG502S9GT; Eukaryota.
DR   HOGENOM; CLU_131611_2_0_1; -.
DR   OMA; FMLTPAT; -.
DR   Proteomes; UP000001628; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR020164; Cyt_c_Oxase_assmbl_COX16.
DR   Pfam; PF14138; COX16; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..22
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..135
FT                   /note="Cytochrome c oxidase assembly protein COX16,
FT                   mitochondrial"
FT                   /id="PRO_0000280651"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   135 AA;  15526 MW;  B81F229EF8EC6C00 CRC64;
     MVFQAKRFRP SNSFGSTLSE RLGAKYRANL SKHPFLLFGL PFISVIIAGS FVLTPATAMR
     YERFDRKVQQ VSQEEAMGLG LKGPEGDDGV QIKRNPRRRI LGSEKEEYYK LMAKDLDNWE
     QKRVKRFKGE PDGRL