COX16_YEAST
ID COX16_YEAST Reviewed; 118 AA.
AC P47081; D6VWH2;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Cytochrome c oxidase assembly protein COX16, mitochondrial;
DE Flags: Precursor;
GN Name=COX16; OrderedLocusNames=YJL003W; ORFNames=J1403, YJR83.2;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=12446688; DOI=10.1074/jbc.m209893200;
RA Carlson C.G., Barrientos A., Tzagoloff A., Glerum D.M.;
RT "COX16 encodes a novel protein required for the assembly of cytochrome
RT oxidase in Saccharomyces cerevisiae.";
RL J. Biol. Chem. 278:3770-3775(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [7]
RP FUNCTION.
RX PubMed=28821616; DOI=10.1074/jbc.m117.801811;
RA Su C.H., Tzagoloff A.;
RT "Cox16 protein is physically associated with Cox1p assembly intermediates
RT and with cytochrome oxidase.";
RL J. Biol. Chem. 292:16277-16283(2017).
CC -!- FUNCTION: Required for the assembly of the mitochondrial respiratory
CC chain complex IV (CIV), also known as cytochrome c oxidase
CC (PubMed:12446688, PubMed:28821616). May participate in merging the COX1
CC and COX2 assembly lines (PubMed:28821616).
CC {ECO:0000269|PubMed:12446688, ECO:0000269|PubMed:28821616}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000305|PubMed:12446688}; Single-pass membrane protein
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 672 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the COX16 family. {ECO:0000305}.
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DR EMBL; X87611; CAA60919.1; -; Genomic_DNA.
DR EMBL; Z49278; CAA89293.1; -; Genomic_DNA.
DR EMBL; AY558241; AAS56567.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08788.1; -; Genomic_DNA.
DR PIR; S55185; S55185.
DR RefSeq; NP_012531.1; NM_001181437.1.
DR AlphaFoldDB; P47081; -.
DR BioGRID; 33754; 88.
DR STRING; 4932.YJL003W; -.
DR MaxQB; P47081; -.
DR PaxDb; P47081; -.
DR PRIDE; P47081; -.
DR EnsemblFungi; YJL003W_mRNA; YJL003W; YJL003W.
DR GeneID; 853454; -.
DR KEGG; sce:YJL003W; -.
DR SGD; S000003540; COX16.
DR VEuPathDB; FungiDB:YJL003W; -.
DR eggNOG; ENOG502S9GT; Eukaryota.
DR GeneTree; ENSGT00940000175347; -.
DR HOGENOM; CLU_131611_2_0_1; -.
DR InParanoid; P47081; -.
DR OMA; FMLTPAT; -.
DR BioCyc; YEAST:G3O-31482-MON; -.
DR PRO; PR:P47081; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P47081; protein.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IMP:SGD.
DR InterPro; IPR020164; Cyt_c_Oxase_assmbl_COX16.
DR Pfam; PF14138; COX16; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..118
FT /note="Cytochrome c oxidase assembly protein COX16,
FT mitochondrial"
FT /id="PRO_0000203080"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 118 AA; 14077 MW; 4A45F140B802DCC9 CRC64;
MSFSGKKFRS RRQQLVYEAS LAGRYKKALS KHPFLFFGLP FCATIVLGSF WLSSFTAIKY
EQGDRKVQEI NEEDILKIRK NQREFDIKEE YYRLQGLSEE DWEPVRVARL KDESENVW
