ID   COX18_KLULA             Reviewed;         313 AA.
AC   P78990;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX18, mitochondrial;
DE   AltName: Full=Cytochrome c oxidase assembly protein 18;
DE   Flags: Precursor;
GN   Name=COX18; OrderedLocusNames=KLLA0B08019g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC MYA-539 / JBD100;
RX   PubMed=9342406; DOI=10.1007/s002940050276;
RA   Hikkel I., Gbelska Y., van der Aart Q.J.M., Lubecu G., Subik J.;
RT   "Cloning and characterization of KlCOX18, a gene required for activity of
RT   cytochrome oxidase in Kluyveromyces lactis.";
RL   Curr. Genet. 32:267-272(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the insertion of integral membrane proteins into
CC       the mitochondrial inner membrane. Essential for the activity and
CC       assembly of cytochrome c oxidase.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. {ECO:0000305}.
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DR   EMBL; Y11373; CAA72198.1; -; Genomic_DNA.
DR   EMBL; CR382122; CAH02280.1; -; Genomic_DNA.
DR   RefSeq; XP_451887.1; XM_451887.1.
DR   AlphaFoldDB; P78990; -.
DR   STRING; 28985.XP_451887.1; -.
DR   EnsemblFungi; CAH02280; CAH02280; KLLA0_B08019g.
DR   GeneID; 2897124; -.
DR   KEGG; kla:KLLA0_B08019g; -.
DR   eggNOG; KOG1239; Eukaryota.
DR   HOGENOM; CLU_029282_2_1_1; -.
DR   InParanoid; P78990; -.
DR   OMA; WQRKRIV; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:EnsemblFungi.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:EnsemblFungi.
DR   GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; IEA:EnsemblFungi.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..313
FT                   /note="Cytochrome c oxidase assembly protein COX18,
FT                   mitochondrial"
FT                   /id="PRO_0000020356"
FT   TOPO_DOM        ?..208
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        230..272
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..313
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   313 AA;  34963 MW;  97E084DFBC5C3CE6 CRC64;
     MLLRRLPAVH FAKGSRQFGS LQAIADSFVQ LHDASGVPWL VLIPTATFAL RTVFTLPLSI
     WQRKRIVKQQ ELRKVVQSVP PVVKLRLASM TAKANDEELT SSGSAIQTKE ETVGALQRGK
     RQLTPDQITM LSLKEMRKRQ KVLFKKYNVQ MWKNSVLPLV QVPLWVTMSM GLRKLTDSRL
     VDTNMPHAHV LQDLSETSWL THIGSLDLSL PLDAAPMLIP IILGTVSMIN VEYNGKTMQA
     TAVGTSGITT ATDTQSRTSQ TVNSILTATR LSTIFLIGVS TQASVLLSLY WITSQVYSLI
     QNRILDLLWP YQR