ID   COX18_PONAB             Reviewed;         334 AA.
AC   Q5R7D0;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX18, mitochondrial;
DE   Flags: Precursor;
GN   Name=COX18; Synonyms=OXA1L2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial membrane insertase required for the
CC       translocation of the C-terminus of cytochrome c oxidase subunit II (MT-
CC       CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-
CC       CO2/COX2 maturation following the COX20-mediated stabilization of newly
CC       synthesized MT-CO2/COX2 protein and before the action of the
CC       metallochaperones SCO1/2. Essential for the assembly and stability of
CC       the mitochondrial respiratory chain complex IV (also known as
CC       cytochrome c oxidase). {ECO:0000250|UniProtKB:Q8N8Q8}.
CC   -!- SUBUNIT: Found in a complex with TMEM177, COA6, MT-CO2/COX2, COX20,
CC       SCO1 and SCO2. Interacts transiently with MT-CO2/COX2 during its
CC       maturation. Interacts with COX20 in a MT-CO2/COX2-dependent manner.
CC       {ECO:0000250|UniProtKB:Q8N8Q8}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q8N8Q8}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR860188; CAH92330.1; -; mRNA.
DR   RefSeq; NP_001126369.1; NM_001132897.1.
DR   AlphaFoldDB; Q5R7D0; -.
DR   STRING; 9601.ENSPPYP00000016549; -.
DR   GeneID; 100173350; -.
DR   KEGG; pon:100173350; -.
DR   CTD; 285521; -.
DR   eggNOG; KOG1239; Eukaryota.
DR   InParanoid; Q5R7D0; -.
DR   OrthoDB; 1146603at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0032977; F:membrane insertase activity; ISS:UniProtKB.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR   GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; ISS:UniProtKB.
DR   GO; GO:0051204; P:protein insertion into mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0008535; P:respiratory chain complex IV assembly; ISS:UniProtKB.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..334
FT                   /note="Cytochrome c oxidase assembly protein COX18,
FT                   mitochondrial"
FT                   /id="PRO_0000020355"
FT   TOPO_DOM        ?..167
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        189..224
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        246..263
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..334
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   334 AA;  37103 MW;  4F2EA2777AD2E1E6 CRC64;
     MLCRLGGRWL RPLPALQLWA RDPPLAPVPT SGAKRPTLPV WAVTPVSAVH ANGWYEALAA
     SSPVRVAEEV LLGVHAATGL PWWGSIPLST AALRGAVTLP LAAYQHYILA KVENLQPEIK
     TIARHLNQEV AVRANQLGWS KRDARLTYLK NMRRLISELY VRDNCHPFKA TVLVWIQLPM
     WIFMSFALRN LSTGAAHSEA GFSVEEQLAA GGILWFSDLT APDPTWILPV SLGVINLLIV
     EICVLQKIGM SRFQTYITYF VRAMSVLMIP IAATVPSSIV LYWLCSSFVG LSQNLLLRSP
     GFRQLCRIPS TKSDSETPYK DIFAAFNTKF ISRK