COX18_SCHPO
ID COX18_SCHPO Reviewed; 202 AA.
AC O94587;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Cytochrome c oxidase assembly protein cox18, mitochondrial;
DE AltName: Full=Sp3;
DE AltName: Full=cox18sp+;
DE Flags: Precursor;
GN Name=cox18; Synonyms=oxa1-3, oxa103; ORFNames=SPCC1442.15c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP IDENTIFICATION, AND FUNCTION.
RX PubMed=16911509; DOI=10.1111/j.1567-1364.2006.00083.x;
RA Gaisne M., Bonnefoy N.;
RT "The COX18 gene, involved in mitochondrial biogenesis, is functionally
RT conserved and tightly regulated in humans and fission yeast.";
RL FEMS Yeast Res. 6:869-882(2006).
CC -!- FUNCTION: Required for the insertion of integral membrane proteins into
CC the mitochondrial inner membrane. Essential for the activity and
CC assembly of cytochrome c oxidase. Plays a central role in the
CC translocation and export of the C-terminal part of the cox2 protein
CC into the mitochondrial intermembrane space.
CC {ECO:0000269|PubMed:16911509}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. {ECO:0000305}.
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DR EMBL; CU329672; CAA21449.1; -; Genomic_DNA.
DR PIR; T40980; T40980.
DR RefSeq; NP_588329.1; NM_001023320.2.
DR AlphaFoldDB; O94587; -.
DR SMR; O94587; -.
DR BioGRID; 275704; 2.
DR STRING; 4896.SPCC1442.15c.1; -.
DR TCDB; 2.A.9.1.4; the membrane protein insertase (yidc/alb3/oxa1) family.
DR PaxDb; O94587; -.
DR PRIDE; O94587; -.
DR EnsemblFungi; SPCC1442.15c.1; SPCC1442.15c.1:pep; SPCC1442.15c.
DR GeneID; 2539132; -.
DR KEGG; spo:SPCC1442.15c; -.
DR PomBase; SPCC1442.15c; cox18.
DR VEuPathDB; FungiDB:SPCC1442.15c; -.
DR eggNOG; KOG1239; Eukaryota.
DR HOGENOM; CLU_029282_2_3_1; -.
DR InParanoid; O94587; -.
DR OMA; YWTTSAI; -.
DR PhylomeDB; O94587; -.
DR PRO; PR:O94587; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IGI:PomBase.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0032977; F:membrane insertase activity; IGI:PomBase.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IMP:PomBase.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; IGI:PomBase.
DR GO; GO:0051204; P:protein insertion into mitochondrial membrane; IGI:UniProtKB.
DR GO; GO:0008535; P:respiratory chain complex IV assembly; IGI:UniProtKB.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..202
FT /note="Cytochrome c oxidase assembly protein cox18,
FT mitochondrial"
FT /id="PRO_0000020360"
FT TOPO_DOM ?..14
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..74
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000305"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..125
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..168
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000305"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..202
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
SQ SEQUENCE 202 AA; 23011 MW; D51567DE2A5DA232 CRC64;
MLQTLIGVHS YMPWCYEIPA MAIFLRSTIT LPIAIASLKT ARRFVQVQPL IKEAKKRCRT
NTDFRTVRKK LYKRFNCHPL MIYALPITQL PLFAFASYQL RQAVDVCPES MSTEGMLWFT
DLTLPDPHGV LPAVLAVTYL TNMSILKRPS DSRLLKIFNT AGIMSAFFVS FMAFKTSTAL
SLYWTTSAIY SLVQNVALRK LL
