ID   COX19_CANAL             Reviewed;         132 AA.
AC   Q5AL10; A0A1D8PFP1; Q5ALD5;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX19;
GN   Name=COX19; OrderedLocusNames=CAALFM_C113410WA;
GN   ORFNames=CaO19.12432, CaO19.4967;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Required for the assembly of mitochondrial cytochrome c
CC       oxidase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC       intermembrane space {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COX19 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW26946.1; -; Genomic_DNA.
DR   RefSeq; XP_019330723.1; XM_019475178.1.
DR   AlphaFoldDB; Q5AL10; -.
DR   SMR; Q5AL10; -.
DR   STRING; 237561.Q5AL10; -.
DR   GeneID; 3636220; -.
DR   KEGG; cal:CAALFM_C113410WA; -.
DR   CGD; CAL0000176572; COX19.
DR   VEuPathDB; FungiDB:C1_13410W_A; -.
DR   eggNOG; KOG3477; Eukaryota.
DR   HOGENOM; CLU_141947_2_0_1; -.
DR   InParanoid; Q5AL10; -.
DR   OrthoDB; 1595090at2759; -.
DR   PRO; PR:Q5AL10; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IBA:GO_Central.
DR   PROSITE; PS51808; CHCH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Disulfide bond; Mitochondrion; Reference proteome.
FT   CHAIN           1..132
FT                   /note="Cytochrome c oxidase assembly protein COX19"
FT                   /id="PRO_0000122285"
FT   DOMAIN          28..71
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          83..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           31..41
FT                   /note="Cx9C motif 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           53..63
FT                   /note="Cx9C motif 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   COMPBIAS        87..101
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        31..63
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        41..53
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ   SEQUENCE   132 AA;  14633 MW;  77FC80FD8065B87A CRC64;
     MATGAPGGNF RTWTPTPPER GSFPLDHDGE CKEYMTKYLT CMKFTENKNA PNCRILAKQY
     LKCRMDNQLM EKSDWDSLGL VNLPGENDVE LDHHHHLNNN NTKADGKSGS SNSNQNLANT
     TNNNTGTSSG TK