COX19_CRYNB
ID COX19_CRYNB Reviewed; 115 AA.
AC P0CM87; Q55L07; Q5KAH3;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 31.
DE RecName: Full=Cytochrome c oxidase assembly protein COX19;
GN Name=COX19; OrderedLocusNames=CNBJ1770;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Required for the assembly of mitochondrial cytochrome c
CC oxidase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC intermembrane space {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COX19 family. {ECO:0000305}.
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DR EMBL; AAEY01000049; EAL18535.1; -; Genomic_DNA.
DR RefSeq; XP_773182.1; XM_768089.1.
DR AlphaFoldDB; P0CM87; -.
DR SMR; P0CM87; -.
DR EnsemblFungi; AAW45829; AAW45829; CNJ01690.
DR EnsemblFungi; EAL18535; EAL18535; CNBJ1770.
DR GeneID; 4938519; -.
DR KEGG; cnb:CNBJ1770; -.
DR VEuPathDB; FungiDB:CNBJ1770; -.
DR HOGENOM; CLU_141947_2_0_1; -.
DR Proteomes; UP000001435; Chromosome 10.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR InterPro; IPR010625; CHCH.
DR InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR Pfam; PF06747; CHCH; 1.
DR SUPFAM; SSF47072; SSF47072; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Disulfide bond; Mitochondrion.
FT CHAIN 1..115
FT /note="Cytochrome c oxidase assembly protein COX19"
FT /id="PRO_0000410046"
FT DOMAIN 27..69
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 30..40
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 51..61
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 30..61
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 40..51
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 115 AA; 12552 MW; 591B4E9DA043FD4D CRC64;
MSFGRPGFAD VFKPSPPARG SFPLDHDGEC KAFMISYLKC MKENANDNGK CRLFSKQYLE
CRMDKGLMAR DDMANLGLGD VVDPSALPPA STQTTTAPLS NPPHVPQPPS SEHRI