ID   COX19_CRYNJ             Reviewed;         115 AA.
AC   P0CM86; Q55L07; Q5KAH3;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX19;
GN   Name=COX19; OrderedLocusNames=CNJ01690;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for the assembly of mitochondrial cytochrome c
CC       oxidase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC       intermembrane space {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COX19 family. {ECO:0000305}.
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DR   EMBL; AE017350; AAW45829.1; -; Genomic_DNA.
DR   RefSeq; XP_567346.1; XM_567346.1.
DR   AlphaFoldDB; P0CM86; -.
DR   SMR; P0CM86; -.
DR   STRING; 5207.AAW45829; -.
DR   PaxDb; P0CM86; -.
DR   EnsemblFungi; AAW45829; AAW45829; CNJ01690.
DR   GeneID; 3254083; -.
DR   KEGG; cne:CNJ01690; -.
DR   VEuPathDB; FungiDB:CNJ01690; -.
DR   eggNOG; KOG3477; Eukaryota.
DR   HOGENOM; CLU_141947_2_0_1; -.
DR   InParanoid; P0CM86; -.
DR   OMA; LECRMDN; -.
DR   OrthoDB; 1595090at2759; -.
DR   Proteomes; UP000002149; Chromosome 10.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IBA:GO_Central.
DR   InterPro; IPR010625; CHCH.
DR   InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR   Pfam; PF06747; CHCH; 1.
DR   SUPFAM; SSF47072; SSF47072; 1.
DR   PROSITE; PS51808; CHCH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Disulfide bond; Mitochondrion; Reference proteome.
FT   CHAIN           1..115
FT                   /note="Cytochrome c oxidase assembly protein COX19"
FT                   /id="PRO_0000122287"
FT   DOMAIN          27..69
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          80..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           30..40
FT                   /note="Cx9C motif 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           51..61
FT                   /note="Cx9C motif 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        30..61
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        40..51
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ   SEQUENCE   115 AA;  12552 MW;  591B4E9DA043FD4D CRC64;
     MSFGRPGFAD VFKPSPPARG SFPLDHDGEC KAFMISYLKC MKENANDNGK CRLFSKQYLE
     CRMDKGLMAR DDMANLGLGD VVDPSALPPA STQTTTAPLS NPPHVPQPPS SEHRI