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COX19_MOUSE
ID   COX19_MOUSE             Reviewed;          92 AA.
AC   Q8K0C8;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX19;
GN   Name=Cox19;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   DISULFIDE BONDS.
RX   PubMed=23676665; DOI=10.1091/mbc.e12-12-0862;
RA   Fischer M., Horn S., Belkacemi A., Kojer K., Petrungaro C., Habich M.,
RA   Ali M., Kuettner V., Bien M., Kauff F., Dengjel J., Herrmann J.M.,
RA   Riemer J.;
RT   "Protein import and oxidative folding in the mitochondrial intermembrane
RT   space of intact mammalian cells.";
RL   Mol. Biol. Cell 24:2160-2170(2013).
CC   -!- FUNCTION: Required for the transduction of an SCO1-dependent redox
CC       signal from the mitochondrion to ATP7A to regulate cellular copper
CC       homeostasis. May be required for the assembly of mitochondrial
CC       cytochrome c oxidase. {ECO:0000250|UniProtKB:Q3E731,
CC       ECO:0000250|UniProtKB:Q49B96}.
CC   -!- SUBUNIT: Interacts with CHCHD4/MIA40 forming transient intermolecular
CC       disulfide bridges. {ECO:0000250|UniProtKB:Q49B96}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q49B96}. Mitochondrion intermembrane space
CC       {ECO:0000250|UniProtKB:Q49B96}. Mitochondrion
CC       {ECO:0000250|UniProtKB:Q49B96}. Note=Partitions between mitochondria
CC       and the cytosol in a copper-dependent manner. Enriched in the cytosol
CC       when intracellular copper concentrations are elevated.
CC       {ECO:0000250|UniProtKB:Q49B96}.
CC   -!- SIMILARITY: Belongs to the COX19 family. {ECO:0000305}.
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DR   EMBL; BC031792; AAH31792.1; -; mRNA.
DR   CCDS; CCDS39350.1; -.
DR   RefSeq; NP_932097.1; NM_197980.1.
DR   AlphaFoldDB; Q8K0C8; -.
DR   SMR; Q8K0C8; -.
DR   BioGRID; 212613; 1.
DR   STRING; 10090.ENSMUSP00000062046; -.
DR   iPTMnet; Q8K0C8; -.
DR   PhosphoSitePlus; Q8K0C8; -.
DR   MaxQB; Q8K0C8; -.
DR   PaxDb; Q8K0C8; -.
DR   PeptideAtlas; Q8K0C8; -.
DR   PRIDE; Q8K0C8; -.
DR   ProteomicsDB; 285267; -.
DR   Antibodypedia; 34791; 86 antibodies from 18 providers.
DR   DNASU; 68033; -.
DR   Ensembl; ENSMUST00000049630; ENSMUSP00000062046; ENSMUSG00000045438.
DR   GeneID; 68033; -.
DR   KEGG; mmu:68033; -.
DR   UCSC; uc009agj.1; mouse.
DR   CTD; 90639; -.
DR   MGI; MGI:1915283; Cox19.
DR   VEuPathDB; HostDB:ENSMUSG00000045438; -.
DR   eggNOG; KOG3477; Eukaryota.
DR   GeneTree; ENSGT00390000016895; -.
DR   HOGENOM; CLU_141947_5_0_1; -.
DR   InParanoid; Q8K0C8; -.
DR   OMA; LECRMDN; -.
DR   OrthoDB; 1595090at2759; -.
DR   PhylomeDB; Q8K0C8; -.
DR   TreeFam; TF321525; -.
DR   Reactome; R-MMU-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-MMU-611105; Respiratory electron transport.
DR   Reactome; R-MMU-9707564; Cytoprotection by HMOX1.
DR   BioGRID-ORCS; 68033; 20 hits in 71 CRISPR screens.
DR   ChiTaRS; Cox19; mouse.
DR   PRO; PR:Q8K0C8; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q8K0C8; protein.
DR   Bgee; ENSMUSG00000045438; Expressed in interventricular septum and 258 other tissues.
DR   ExpressionAtlas; Q8K0C8; baseline and differential.
DR   Genevisible; Q8K0C8; MM.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006878; P:cellular copper ion homeostasis; ISS:UniProtKB.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IBA:GO_Central.
DR   InterPro; IPR010625; CHCH.
DR   InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR   Pfam; PF06747; CHCH; 1.
DR   SUPFAM; SSF47072; SSF47072; 1.
DR   PROSITE; PS51808; CHCH; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Disulfide bond; Mitochondrion; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q49B96"
FT   CHAIN           2..92
FT                   /note="Cytochrome c oxidase assembly protein COX19"
FT                   /id="PRO_0000273152"
FT   DOMAIN          27..69
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           30..40
FT                   /note="Cx9C motif 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           51..61
FT                   /note="Cx9C motif 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q49B96"
FT   DISULFID        30..61
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150,
FT                   ECO:0000305|PubMed:23676665"
FT   DISULFID        40..51
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150,
FT                   ECO:0000305|PubMed:23676665"
SQ   SEQUENCE   92 AA;  10821 MW;  B3F616804658F594 CRC64;
     MSTAMNFGTK SFQPRPPDKG SFPLDHFGEC KSFKEKFMRC LRDKNYENAL CRNESKEYLM
     CRMQRQLMAP EPLEKLGFRD LMEGKPEAKD EC
 
 
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