COX19_YEAST
ID COX19_YEAST Reviewed; 98 AA.
AC Q3E731; D6VXY5;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Cytochrome c oxidase assembly protein COX19;
GN Name=COX19; OrderedLocusNames=YLL018C-A;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION, MUTAGENESIS OF ARG-63, AND SUBCELLULAR LOCATION.
RX PubMed=12171940; DOI=10.1074/jbc.m207348200;
RA Nobrega M.P., Bandeira S.C.B., Beers J., Tzagoloff A.;
RT "Characterization of COX19, a widely distributed gene required for
RT expression of mitochondrial cytochrome oxidase.";
RL J. Biol. Chem. 277:40206-40211(2002).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RX PubMed=22984289; DOI=10.1074/mcp.m112.021105;
RA Voegtle F.N., Burkhart J.M., Rao S., Gerbeth C., Hinrichs J.,
RA Martinou J.C., Chacinska A., Sickmann A., Zahedi R.P., Meisinger C.;
RT "Intermembrane space proteome of yeast mitochondria.";
RL Mol. Cell. Proteomics 11:1840-1852(2012).
CC -!- FUNCTION: Required for the assembly of mitochondrial cytochrome c
CC oxidase. {ECO:0000269|PubMed:12171940}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion intermembrane space
CC {ECO:0000269|PubMed:22984289}.
CC -!- MISCELLANEOUS: Present with 5750 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the COX19 family. {ECO:0000305}.
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DR EMBL; Z73125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK006945; DAA09301.1; -; Genomic_DNA.
DR RefSeq; NP_013082.1; NM_001184338.1.
DR AlphaFoldDB; Q3E731; -.
DR SMR; Q3E731; -.
DR BioGRID; 31234; 43.
DR STRING; 4932.YLL018C-A; -.
DR PaxDb; Q3E731; -.
DR PRIDE; Q3E731; -.
DR EnsemblFungi; YLL018C-A_mRNA; YLL018C-A; YLL018C-A.
DR GeneID; 850642; -.
DR KEGG; sce:YLL018C-A; -.
DR SGD; S000007245; COX19.
DR VEuPathDB; FungiDB:YLL018C-A; -.
DR eggNOG; KOG3477; Eukaryota.
DR GeneTree; ENSGT00390000016895; -.
DR HOGENOM; CLU_141947_3_1_1; -.
DR InParanoid; Q3E731; -.
DR OMA; LECRMDN; -.
DR BioCyc; YEAST:G3O-32559-MON; -.
DR PRO; PR:Q3E731; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q3E731; protein.
DR GO; GO:0005829; C:cytosol; IDA:SGD.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
DR GO; GO:0005507; F:copper ion binding; IDA:SGD.
DR GO; GO:0030001; P:metal ion transport; IDA:SGD.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IDA:SGD.
DR PROSITE; PS51808; CHCH; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Disulfide bond; Mitochondrion; Reference proteome.
FT CHAIN 1..98
FT /note="Cytochrome c oxidase assembly protein COX19"
FT /id="PRO_0000122292"
FT DOMAIN 27..70
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 30..40
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 52..62
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 30..62
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 40..52
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MUTAGEN 63
FT /note="R->T: In COX19-1; causes a respiratory-deficient
FT phenotype because of lack of cytochrome c activity."
FT /evidence="ECO:0000269|PubMed:12171940"
SQ SEQUENCE 98 AA; 11105 MW; AAF79F52F46FD3BF CRC64;
MSGNPGSSLS ALRPTPPERG SFPLDHDGEC TKYMQEYLKC MQLVQNENAM NCRLLAKDYL
RCRMDHQLMD YDEWSHLGLP EDAPGNNGKT IKDATDNK
