ID   COX1_PARVE              Reviewed;          25 AA.
AC   Q00502;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Cytochrome c oxidase subunit 1;
DE            EC=7.1.1.9;
DE   AltName: Full=Cytochrome aa3 subunit 1;
DE   AltName: Full=Cytochrome c oxidase polypeptide I;
DE   Flags: Fragment;
GN   Name=ctaD; Synonyms=coxI;
OS   Paracoccus versutus (Thiobacillus versutus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Paracoccus.
OX   NCBI_TaxID=34007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 25364 / DSM 582 / JCM 20754 / NBRC 14567 / VKM B-2163;
RX   PubMed=1339423; DOI=10.1128/jb.174.11.3707-3714.1992;
RA   Ubbink M., van Beeumen J., Canters G.W.;
RT   "Cytochrome c550 from Thiobacillus versutus: cloning, expression in
RT   Escherichia coli, and purification of the heterologous holoprotein.";
RL   J. Bacteriol. 174:3707-3714(1992).
CC   -!- FUNCTION: Subunit I and II form the functional core of the enzyme
CC       complex. Electrons originating in cytochrome c are transferred via heme
CC       a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This
CC       cytochrome c oxidase shows proton pump activity across the membrane in
CC       addition to the electron transfer.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC         [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC       Note=Binds 1 copper B ion per subunit.;
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC       Note=Binds 2 heme groups per subunit.;
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
CC       {ECO:0000305}.
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DR   EMBL; X62808; CAA44628.1; -; Genomic_DNA.
DR   PIR; S23631; S23631.
DR   AlphaFoldDB; Q00502; -.
DR   STRING; 34007.IT40_05940; -.
DR   eggNOG; COG0843; Bacteria.
DR   UniPathway; UPA00705; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Copper; Electron transport; Heme;
KW   Hydrogen ion transport; Ion transport; Iron; Membrane; Metal-binding;
KW   Respiratory chain; Translocase; Transmembrane; Transport.
FT   CHAIN           1..>25
FT                   /note="Cytochrome c oxidase subunit 1"
FT                   /id="PRO_0000183457"
FT   NON_TER         25
SQ   SEQUENCE   25 AA;  2887 MW;  81CBFABB2C72937C CRC64;
     MADAAVHGHG DHHDTRGFFT RWFMS