COX1_THETH
ID COX1_THETH Reviewed; 108 AA.
AC Q56408;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Cytochrome c oxidase subunit 1;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome c ba(3) subunit I;
DE AltName: Full=Cytochrome c oxidase polypeptide I;
DE AltName: Full=Cytochrome cba3 subunit 1;
DE Flags: Fragment;
GN Name=cbaA;
OS Thermus thermophilus.
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=274;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=VK1;
RX PubMed=9208917; DOI=10.1111/j.1432-1033.1997.00291.x;
RA Serganov A., Rak A., Garber M.B., Reinbolt J., Ehresmann B., Ehresmann C.,
RA Grunberg-Manago M., Portier C.;
RT "Ribosomal protein S15 from Thermus thermophilus -- cloning, sequencing,
RT overexpression of the gene and RNA-binding properties of the protein.";
RL Eur. J. Biochem. 246:291-300(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC Note=Binds 2 heme groups. {ECO:0000250};
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000250};
CC Note=Binds a copper B center. {ECO:0000250};
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
CC {ECO:0000305}.
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DR EMBL; Z84206; CAB06339.1; -; Genomic_DNA.
DR PIR; T52481; T52481.
DR PDB; 1XME; X-ray; 2.30 A; A=1-108.
DR PDBsum; 1XME; -.
DR AlphaFoldDB; Q56408; -.
DR SMR; Q56408; -.
DR IntAct; Q56408; 2.
DR DrugBank; DB02451; B-nonylglucoside.
DR UniPathway; UPA00705; -.
DR EvolutionaryTrace; Q56408; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.210.10; -; 1.
DR InterPro; IPR023616; Cyt_c_oxase-like_su1_dom.
DR InterPro; IPR036927; Cyt_c_oxase-like_su1_sf.
DR InterPro; IPR000883; Cyt_C_Oxase_1.
DR Pfam; PF00115; COX1; 1.
DR SUPFAM; SSF81442; SSF81442; 1.
DR PROSITE; PS50855; COX1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Copper; Electron transport; Heme;
KW Hydrogen ion transport; Ion transport; Iron; Membrane; Metal-binding;
KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN <1..>108
FT /note="Cytochrome c oxidase subunit 1"
FT /id="PRO_0000183463"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 49
FT /ligand="heme a3"
FT /ligand_id="ChEBI:CHEBI:83282"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
FT BINDING 51
FT /ligand="Fe(II)-heme a"
FT /ligand_id="ChEBI:CHEBI:61715"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
FT NON_TER 1
FT NON_TER 108
FT HELIX 9..31
FT /evidence="ECO:0007829|PDB:1XME"
FT HELIX 34..36
FT /evidence="ECO:0007829|PDB:1XME"
FT HELIX 37..40
FT /evidence="ECO:0007829|PDB:1XME"
FT HELIX 45..53
FT /evidence="ECO:0007829|PDB:1XME"
FT TURN 54..56
FT /evidence="ECO:0007829|PDB:1XME"
FT HELIX 57..64
FT /evidence="ECO:0007829|PDB:1XME"
FT HELIX 66..74
FT /evidence="ECO:0007829|PDB:1XME"
FT HELIX 80..108
FT /evidence="ECO:0007829|PDB:1XME"
SQ SEQUENCE 108 AA; 11634 MW; 7DEB6C38DD575368 CRC64;
IRALPWDNPA FVAPVLGLLG FIPGGAGGIV NASFTLDYVV HNTAWVPGHF HLQVASLVTL
TAMGSLYWLL PNLTGKPISD AQRRLGLAVV WLWFLGMMIM AVGLHWAG
