ID   COX20_ASHGO             Reviewed;         194 AA.
AC   Q75D23;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX20, mitochondrial;
DE   Flags: Precursor;
GN   Name=COX20; OrderedLocusNames=ABR199C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in the assembly of the cytochrome c oxidase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COX20 family. {ECO:0000305}.
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DR   EMBL; AE016815; AAS50972.1; -; Genomic_DNA.
DR   RefSeq; NP_983148.1; NM_208501.1.
DR   AlphaFoldDB; Q75D23; -.
DR   STRING; 33169.AAS50972; -.
DR   EnsemblFungi; AAS50972; AAS50972; AGOS_ABR199C.
DR   GeneID; 4619258; -.
DR   KEGG; ago:AGOS_ABR199C; -.
DR   eggNOG; ENOG502S3BD; Eukaryota.
DR   HOGENOM; CLU_125578_0_0_1; -.
DR   InParanoid; Q75D23; -.
DR   OMA; IVGWEQC; -.
DR   Proteomes; UP000000591; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:EnsemblFungi.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IBA:GO_Central.
DR   GO; GO:0043069; P:negative regulation of programmed cell death; IEA:EnsemblFungi.
DR   GO; GO:1902884; P:positive regulation of response to oxidative stress; IEA:EnsemblFungi.
DR   GO; GO:0016485; P:protein processing; IEA:EnsemblFungi.
DR   InterPro; IPR022533; Cox20.
DR   PANTHER; PTHR31586; PTHR31586; 1.
DR   Pfam; PF12597; DUF3767; 1.
DR   PIRSF; PIRSF007871; Cox20; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..194
FT                   /note="Cytochrome c oxidase assembly protein COX20,
FT                   mitochondrial"
FT                   /id="PRO_0000227689"
FT   TOPO_DOM        ?..95
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        96..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        116..119
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        120..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        138..194
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   194 AA;  21786 MW;  BB1D6E9B4EE1769D CRC64;
     MAWWPFSRNN KPGVPEQDQV AAAPVQQRPA EPLPTNYTPG QRLLLEDTRP RFDTQSSASQ
     QAVQRERATL ADAWKTVRWE DFSLERMAGI PCFRDAGMAG FSAMVVAGSV TFLFHKNPVR
     AANWGVGGLL LGSIVGWEQC RMQRRRSFQV AEMARQTVAA KEAPMLRKPD NAQKAGAVSQ
     ASELPPKKPW YRFW