COX20_DANRE
ID COX20_DANRE Reviewed; 111 AA.
AC Q6DH88;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Cytochrome c oxidase assembly protein COX20, mitochondrial;
GN Name=cox20; Synonyms=fam36a; ORFNames=zgc:92598;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential for the assembly of the mitochondrial respiratory
CC chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a
CC chaperone in the early steps of cytochrome c oxidase subunit II (MT-
CC CO2/COX2) maturation, stabilizing the newly synthesized protein and
CC presenting it to metallochaperones SCO1/2 which in turn facilitates the
CC incorporation of the mature MT-CO2/COX2 into the assembling CIV
CC holoenzyme. {ECO:0000250|UniProtKB:Q5RI15}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q5RI15}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the COX20 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH76091.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC076091; AAH76091.1; ALT_INIT; mRNA.
DR RefSeq; NP_001002712.2; NM_001002712.2.
DR AlphaFoldDB; Q6DH88; -.
DR STRING; 7955.ENSDARP00000018961; -.
DR PaxDb; Q6DH88; -.
DR Ensembl; ENSDART00000170333; ENSDARP00000136241; ENSDARG00000099997.
DR GeneID; 436985; -.
DR KEGG; dre:436985; -.
DR CTD; 116228; -.
DR ZFIN; ZDB-GENE-040718-467; cox20.
DR eggNOG; ENOG502S3BD; Eukaryota.
DR GeneTree; ENSGT00940000168267; -.
DR HOGENOM; CLU_101495_1_1_1; -.
DR InParanoid; Q6DH88; -.
DR OMA; VSQIPCF; -.
DR OrthoDB; 1623571at2759; -.
DR PhylomeDB; Q6DH88; -.
DR TreeFam; TF323844; -.
DR Reactome; R-DRE-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-DRE-611105; Respiratory electron transport.
DR Reactome; R-DRE-9707564; Cytoprotection by HMOX1.
DR PRO; PR:Q6DH88; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 13.
DR Bgee; ENSDARG00000099997; Expressed in mature ovarian follicle and 22 other tissues.
DR ExpressionAtlas; Q6DH88; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR InterPro; IPR022533; Cox20.
DR PANTHER; PTHR31586; PTHR31586; 1.
DR Pfam; PF12597; DUF3767; 1.
DR PRINTS; PR02049; PROTEINF36A.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..111
FT /note="Cytochrome c oxidase assembly protein COX20,
FT mitochondrial"
FT /id="PRO_0000360425"
FT TOPO_DOM 1..27
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT TRANSMEM 28..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..56
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000305"
FT TRANSMEM 57..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..111
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
SQ SEQUENCE 111 AA; 12279 MW; 7508BCD47CF9849F CRC64;
MTEEDGKTQG MKVLGILDIH NTPCAREAIL HGAAGSVAAG LLHFLATSRV KRSFDVGVAG
FMITTLGSWF YCRYNNAKLR FQQRIIQEGL KNKVFYEGTD LDPTLKKTGD K
