COX20_MOUSE
ID COX20_MOUSE Reviewed; 117 AA.
AC Q9D7J4; Q8BT52;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Cytochrome c oxidase assembly protein COX20, mitochondrial;
GN Name=Cox20; Synonyms=Fam36a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Essential for the assembly of the mitochondrial respiratory
CC chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a
CC chaperone in the early steps of cytochrome c oxidase subunit II (MT-
CC CO2/COX2) maturation, stabilizing the newly synthesized protein and
CC presenting it to metallochaperones SCO1/2 which in turn facilitates the
CC incorporation of the mature MT-CO2/COX2 into the assembling CIV
CC holoenzyme. {ECO:0000250|UniProtKB:Q5RI15}.
CC -!- SUBUNIT: Found in a complex with TMEM177, COA6, MT-CO2/COX2, COX18,
CC SCO1 and SCO2. Interacts with SCO1, SCO2 and COA6 in a MT-CO2/COX2- and
CC COX18-dependent manner. Interacts with COX18 in a MT-CO2/COX2-dependent
CC manner. Interacts with MT-CO2/COX2 and TMEM177.
CC {ECO:0000250|UniProtKB:Q5RI15}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q5RI15}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the COX20 family. {ECO:0000305}.
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DR EMBL; AK009178; BAB26124.1; -; mRNA.
DR EMBL; AK019293; BAC25589.1; -; mRNA.
DR EMBL; BC055277; AAH55277.1; -; mRNA.
DR EMBL; BC059717; AAH59717.1; -; mRNA.
DR CCDS; CCDS15556.1; -.
DR RefSeq; NP_079787.1; NM_025511.2.
DR AlphaFoldDB; Q9D7J4; -.
DR SMR; Q9D7J4; -.
DR STRING; 10090.ENSMUSP00000027781; -.
DR iPTMnet; Q9D7J4; -.
DR PhosphoSitePlus; Q9D7J4; -.
DR SwissPalm; Q9D7J4; -.
DR EPD; Q9D7J4; -.
DR jPOST; Q9D7J4; -.
DR MaxQB; Q9D7J4; -.
DR PaxDb; Q9D7J4; -.
DR PeptideAtlas; Q9D7J4; -.
DR PRIDE; Q9D7J4; -.
DR ProteomicsDB; 283795; -.
DR Antibodypedia; 34716; 78 antibodies from 17 providers.
DR DNASU; 66359; -.
DR Ensembl; ENSMUST00000027781; ENSMUSP00000027781; ENSMUSG00000026500.
DR GeneID; 66359; -.
DR KEGG; mmu:66359; -.
DR UCSC; uc007duz.1; mouse.
DR CTD; 116228; -.
DR MGI; MGI:1913609; Cox20.
DR VEuPathDB; HostDB:ENSMUSG00000026500; -.
DR eggNOG; ENOG502S3BD; Eukaryota.
DR GeneTree; ENSGT00390000016158; -.
DR HOGENOM; CLU_101495_1_1_1; -.
DR InParanoid; Q9D7J4; -.
DR OMA; VSQIPCF; -.
DR OrthoDB; 1623571at2759; -.
DR PhylomeDB; Q9D7J4; -.
DR TreeFam; TF323844; -.
DR Reactome; R-MMU-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-MMU-611105; Respiratory electron transport.
DR Reactome; R-MMU-9707564; Cytoprotection by HMOX1.
DR BioGRID-ORCS; 66359; 22 hits in 72 CRISPR screens.
DR ChiTaRS; Cox20; mouse.
DR PRO; PR:Q9D7J4; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9D7J4; protein.
DR Bgee; ENSMUSG00000026500; Expressed in proximal tubule and 63 other tissues.
DR Genevisible; Q9D7J4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; ISS:UniProtKB.
DR InterPro; IPR022533; Cox20.
DR PANTHER; PTHR31586; PTHR31586; 1.
DR Pfam; PF12597; DUF3767; 1.
DR PRINTS; PR02049; PROTEINF36A.
PE 1: Evidence at protein level;
KW Acetylation; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q5RI15"
FT CHAIN 2..117
FT /note="Cytochrome c oxidase assembly protein COX20,
FT mitochondrial"
FT /id="PRO_0000186816"
FT TOPO_DOM 2..32
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT TRANSMEM 33..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..59
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000305"
FT TRANSMEM 60..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..117
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q5RI15"
SQ SEQUENCE 117 AA; 13163 MW; 2BB4F4EB1C7DEB75 CRC64;
MAAAPEPHET EKKPFKLLGI LDVENTPCAR ESILYGSLGS IVTGLGHFLV TSRIRRSCDV
GVGGFILVTL GCWFHCRYNF AKQRIQERIA REGIKNKILY ESTHLDPERK MKTNNSS
