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COX20_YEAST
ID   COX20_YEAST             Reviewed;         205 AA.
AC   Q04935; D6VSL2;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Cytochrome c oxidase assembly protein COX20, mitochondrial;
DE   Flags: Precursor;
GN   Name=COX20; OrderedLocusNames=YDR231C; ORFNames=YD9934.15c;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204511 / S288c / AB972;
RX   PubMed=8885406; DOI=10.1099/13500872-142-10-2897;
RA   de Virgilio C., DeMarini D.J., Pringle J.R.;
RT   "SPR28, a sixth member of the septin gene family in Saccharomyces
RT   cerevisiae that is expressed specifically in sporulating cells.";
RL   Microbiology 142:2897-2905(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH COX2.
RX   PubMed=10671482; DOI=10.1074/jbc.275.7.4571;
RA   Hell K., Tzagoloff A., Neupert W., Stuart R.A.;
RT   "Identification of Cox20p, a novel protein involved in the maturation and
RT   assembly of cytochrome oxidase subunit 2.";
RL   J. Biol. Chem. 275:4571-4578(2000).
RN   [6]
RP   INTERACTION WITH COX2.
RX   PubMed=11381092; DOI=10.1083/jcb.153.5.1085;
RA   Preuss M., Leonhard K., Hell K., Stuart R.A., Neupert W., Herrmann J.M.;
RT   "Mba1, a novel component of the mitochondrial protein export machinery of
RT   the yeast Saccharomyces cerevisiae.";
RL   J. Cell Biol. 153:1085-1096(2001).
RN   [7]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [8]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 76625 / YPH499;
RX   PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA   Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA   Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA   Pfanner N., Meisinger C.;
RT   "The proteome of Saccharomyces cerevisiae mitochondria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
CC   -!- FUNCTION: Involved in the assembly of the cytochrome oxidase complex.
CC       Required for the maturation and subsequent assembly of the
CC       mitochondrially encoded COX2, the precursor of subunit 2 of cytochrome
CC       oxidase. {ECO:0000269|PubMed:10671482}.
CC   -!- SUBUNIT: Interacts with COX2. {ECO:0000269|PubMed:10671482,
CC       ECO:0000269|PubMed:11381092}.
CC   -!- INTERACTION:
CC       Q04935; P00410: COX2; NbExp=3; IntAct=EBI-36910, EBI-5024;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the COX20 family. {ECO:0000305}.
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DR   EMBL; Z48612; CAA88510.1; -; Genomic_DNA.
DR   EMBL; AY557731; AAS56057.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA12072.1; -; Genomic_DNA.
DR   PIR; S59437; S59437.
DR   RefSeq; NP_010517.1; NM_001180539.1.
DR   AlphaFoldDB; Q04935; -.
DR   BioGRID; 32282; 361.
DR   DIP; DIP-5755N; -.
DR   IntAct; Q04935; 3.
DR   MINT; Q04935; -.
DR   STRING; 4932.YDR231C; -.
DR   iPTMnet; Q04935; -.
DR   MaxQB; Q04935; -.
DR   PaxDb; Q04935; -.
DR   PRIDE; Q04935; -.
DR   EnsemblFungi; YDR231C_mRNA; YDR231C; YDR231C.
DR   GeneID; 851817; -.
DR   KEGG; sce:YDR231C; -.
DR   SGD; S000002639; COX20.
DR   VEuPathDB; FungiDB:YDR231C; -.
DR   eggNOG; ENOG502S3BD; Eukaryota.
DR   HOGENOM; CLU_125578_0_0_1; -.
DR   InParanoid; Q04935; -.
DR   OMA; IVGWEQC; -.
DR   BioCyc; YEAST:G3O-29809-MON; -.
DR   PRO; PR:Q04935; -.
DR   Proteomes; UP000002311; Chromosome IV.
DR   RNAct; Q04935; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0051082; F:unfolded protein binding; IDA:SGD.
DR   GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IMP:SGD.
DR   GO; GO:0043069; P:negative regulation of programmed cell death; IDA:SGD.
DR   GO; GO:1902884; P:positive regulation of response to oxidative stress; IDA:SGD.
DR   GO; GO:0016485; P:protein processing; IMP:SGD.
DR   InterPro; IPR022533; Cox20.
DR   PANTHER; PTHR31586; PTHR31586; 1.
DR   Pfam; PF12597; DUF3767; 1.
DR   PIRSF; PIRSF007871; Cox20; 1.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..205
FT                   /note="Cytochrome c oxidase assembly protein COX20,
FT                   mitochondrial"
FT                   /id="PRO_0000227690"
FT   TOPO_DOM        ?..90
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        91..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        110..115
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        116..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        133..205
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          165..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..198
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   205 AA;  23758 MW;  1E1893856FF8456D CRC64;
     MRWWPWSNQT EDQKQQQQPQ GKADGDRVLT NYSRGQKILL EDTPPKFADD LSNSQLAKKQ
     ERATLKEAWD SIRWSDFSLQ KLTSIPCFRD AGMLGFSSMF LMGSIIFIYH KSPTKATNWA
     MSSLILGSIV GWEQCRLKRQ KSFQIAQLAK ETVAKKEKPM LHNVPHDPSL PGQWEAAKNE
     KQSQFEQSNQ NLSQASSEKK WYKFW
 
 
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