ID   2B_TOBSV                Reviewed;         205 AA.
AC   P89679;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   02-JUN-2021, entry version 35.
DE   RecName: Full=Suppressor of silencing 2b;
DE   AltName: Full=Protein 2b;
GN   ORFNames=ORF2b;
OS   Tobacco streak virus (strain WC) (TSV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Martellivirales; Bromoviridae; Ilarvirus.
OX   NCBI_TaxID=12318;
OH   NCBI_TaxID=4686; Asparagus officinalis (Garden asparagus).
OH   NCBI_TaxID=41562; Dahlia.
OH   NCBI_TaxID=3847; Glycine max (Soybean) (Glycine hispida).
OH   NCBI_TaxID=34274; Gossypium herbaceum (Levant cotton) (Arabian cotton).
OH   NCBI_TaxID=47082; Melilotus albus (White sweet clover) (Melilotus officinalis subsp. albus).
OH   NCBI_TaxID=4097; Nicotiana tabacum (Common tobacco).
OH   NCBI_TaxID=3885; Phaseolus vulgaris (Kidney bean) (French bean).
OH   NCBI_TaxID=137000; Rosa setigera.
OH   NCBI_TaxID=57577; Trifolium pratense (Red clover).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9687875; DOI=10.1007/s007050050366;
RA   Scott S.W., Zimmerman M.T., Ge X.;
RT   "The sequence of RNA 1 and RNA 2 of tobacco streak virus: additional
RT   evidence for the inclusion of alfalfa mosaic virus in the genus
RT   Ilarvirus.";
RL   Arch. Virol. 143:1187-1198(1998).
CC   -!- FUNCTION: Acts as suppressor of RNA-mediated gene silencing, also known
CC       as post-transcriptional gene silencing (PTGS), a mechanism of plant
CC       viral defense that limits the accumulation of viral RNAs. May directly
CC       interfere with the mobile silencing signal (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cucumovirus/ilarvirus protein 2b family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U75538; AAB48410.1; -; Genomic_RNA.
DR   RefSeq; NP_620769.1; NC_003842.1.
DR   GeneID; 962657; -.
DR   KEGG; vg:962657; -.
DR   Proteomes; UP000007795; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome; Suppressor of RNA silencing.
FT   CHAIN           1..205
FT                   /note="Suppressor of silencing 2b"
FT                   /id="PRO_0000402394"
FT   REGION          23..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   205 AA;  22457 MW;  CCDA14BC7BD99479 CRC64;
     MFIPILFLTL TLASADVMTL MESEPQPSTT ESRPSMPPIN SGKPSVTEKP GVELNPGETV
     KVKAEQFNTV NPVELKLEKR IPPGRVGSNC IDCAISNLPK AMFSVKVPKL NINFEVSDFP
     SSRLIFATLA QRVKSIPFIE SLSFPSDIQR MQLRALGDVE VLIFIPKFGW KQILKLSDVV
     SGFDIPKIPS IAPKVESCVG DCLNS