ID   COX23_COCIM             Reviewed;          82 AA.
AC   Q1DJH5; A0A0D6K9M6; J3K0B6;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Cytochrome c oxidase-assembly factor COX23, mitochondrial;
DE   Flags: Precursor;
GN   Name=COX23; ORFNames=CIMG_09538;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Required for the assembly of cytochrome c oxidase.
CC       {ECO:0000250|UniProtKB:P38824}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COX23 family. {ECO:0000305}.
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DR   EMBL; GG704915; EAS28334.2; -; Genomic_DNA.
DR   RefSeq; XP_001239917.2; XM_001239916.2.
DR   AlphaFoldDB; Q1DJH5; -.
DR   SMR; Q1DJH5; -.
DR   STRING; 246410.Q1DJH5; -.
DR   EnsemblFungi; EAS28334; EAS28334; CIMG_09538.
DR   GeneID; 4558905; -.
DR   KEGG; cim:CIMG_09538; -.
DR   VEuPathDB; FungiDB:CIMG_09538; -.
DR   InParanoid; Q1DJH5; -.
DR   OMA; GGDRDMC; -.
DR   OrthoDB; 1617584at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR   SUPFAM; SSF47072; SSF47072; 1.
DR   PROSITE; PS51808; CHCH; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..13
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           14..82
FT                   /note="Cytochrome c oxidase-assembly factor COX23,
FT                   mitochondrial"
FT                   /id="PRO_0000280659"
FT   DOMAIN          35..77
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           38..48
FT                   /note="Cx9C motif 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           59..69
FT                   /note="Cx9C motif 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        38..69
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        48..59
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ   SEQUENCE   82 AA;  9620 MW;  816A323CBC284756 CRC64;
     MSAQAGAAQA NEDESHKYWG KAEQQFKHKP ASQFFDPCQE FADRSIKCMR RNAGDRDMCT
     DYFQAYRDCK KAWMTQRKEA SR