ID   COX23_CRYNJ             Reviewed;          98 AA.
AC   P0CM70; Q55HI5; Q5K723;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Cytochrome c oxidase-assembly factor COX23, mitochondrial;
DE   Flags: Precursor;
GN   Name=COX23; OrderedLocusNames=CNN01390;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for the assembly of cytochrome c oxidase.
CC       {ECO:0000250|UniProtKB:P38824}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COX23 family. {ECO:0000305}.
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DR   EMBL; AE017356; AAW47084.1; -; Genomic_DNA.
DR   RefSeq; XP_568601.1; XM_568601.1.
DR   AlphaFoldDB; P0CM70; -.
DR   SMR; P0CM70; -.
DR   STRING; 5207.AAW47084; -.
DR   PaxDb; P0CM70; -.
DR   EnsemblFungi; AAW47084; AAW47084; CNN01390.
DR   GeneID; 3255493; -.
DR   KEGG; cne:CNN01390; -.
DR   VEuPathDB; FungiDB:CNN01390; -.
DR   eggNOG; KOG4618; Eukaryota.
DR   HOGENOM; CLU_157422_2_0_1; -.
DR   InParanoid; P0CM70; -.
DR   OMA; QSMKCLD; -.
DR   OrthoDB; 1617584at2759; -.
DR   Proteomes; UP000002149; Chromosome 14.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0033108; P:mitochondrial respiratory chain complex assembly; IBA:GO_Central.
DR   InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR   SUPFAM; SSF47072; SSF47072; 1.
DR   PROSITE; PS51808; CHCH; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..18
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..98
FT                   /note="Cytochrome c oxidase-assembly factor COX23,
FT                   mitochondrial"
FT                   /id="PRO_0000280660"
FT   DOMAIN          45..87
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           48..58
FT                   /note="Cx9C motif 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           69..79
FT                   /note="Cx9C motif 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        48..79
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        58..69
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ   SEQUENCE   98 AA;  11194 MW;  9ED31E39CBEBB3B7 CRC64;
     MATQVPPSTT PTPFANRPAP PTKDLEIPED YKKTFRGRGT VSKFVDPCEA ARKASLDCLE
     RTQYNRSECT DFFTAYKECK GNWLAQRKED RMKGRDTV