COX23_YEAST
ID COX23_YEAST Reviewed; 151 AA.
AC P38824; D3DL66;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Cytochrome c oxidase-assembly factor COX23, mitochondrial;
DE Flags: Precursor;
GN Name=COX23; OrderedLocusNames=YHR116W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=15145942; DOI=10.1074/jbc.m405014200;
RA Barros M.H., Johnson A., Tzagoloff A.;
RT "COX23, a homologue of COX17, is required for cytochrome oxidase
RT assembly.";
RL J. Biol. Chem. 279:31943-31947(2004).
RN [7]
RP DOMAIN.
RX PubMed=17095012; DOI=10.1016/j.jmb.2006.10.038;
RA Gabriel K., Milenkovic D., Chacinska A., Mueller J., Guiard B., Pfanner N.,
RA Meisinger C.;
RT "Novel mitochondrial intermembrane space proteins as substrates of the MIA
RT import pathway.";
RL J. Mol. Biol. 365:612-620(2007).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RX PubMed=22984289; DOI=10.1074/mcp.m112.021105;
RA Voegtle F.N., Burkhart J.M., Rao S., Gerbeth C., Hinrichs J.,
RA Martinou J.C., Chacinska A., Sickmann A., Zahedi R.P., Meisinger C.;
RT "Intermembrane space proteome of yeast mitochondria.";
RL Mol. Cell. Proteomics 11:1840-1852(2012).
CC -!- FUNCTION: Required for the assembly of cytochrome c oxidase.
CC {ECO:0000269|PubMed:15145942}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15145942}.
CC Mitochondrion intermembrane space {ECO:0000269|PubMed:15145942,
CC ECO:0000269|PubMed:22984289}.
CC -!- MISCELLANEOUS: Present with 1360 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the COX23 family. {ECO:0000305}.
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DR EMBL; U00059; AAB68866.1; -; Genomic_DNA.
DR EMBL; AY692601; AAT92620.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06810.1; -; Genomic_DNA.
DR PIR; S48958; S48958.
DR RefSeq; NP_011984.1; NM_001179246.1.
DR AlphaFoldDB; P38824; -.
DR SMR; P38824; -.
DR BioGRID; 36549; 272.
DR DIP; DIP-5306N; -.
DR IntAct; P38824; 1.
DR MINT; P38824; -.
DR STRING; 4932.YHR116W; -.
DR MaxQB; P38824; -.
DR PaxDb; P38824; -.
DR PRIDE; P38824; -.
DR EnsemblFungi; YHR116W_mRNA; YHR116W; YHR116W.
DR GeneID; 856516; -.
DR KEGG; sce:YHR116W; -.
DR SGD; S000001158; COX23.
DR VEuPathDB; FungiDB:YHR116W; -.
DR eggNOG; KOG4618; Eukaryota.
DR HOGENOM; CLU_153383_1_0_1; -.
DR InParanoid; P38824; -.
DR OMA; DPCQESS; -.
DR BioCyc; YEAST:G3O-31158-MON; -.
DR PRO; PR:P38824; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38824; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR GO; GO:0033108; P:mitochondrial respiratory chain complex assembly; IMP:SGD.
DR InterPro; IPR010625; CHCH.
DR InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR Pfam; PF06747; CHCH; 1.
DR SUPFAM; SSF47072; SSF47072; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Disulfide bond; Mitochondrion; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..10
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 11..151
FT /note="Cytochrome c oxidase-assembly factor COX23,
FT mitochondrial"
FT /id="PRO_0000202912"
FT DOMAIN 101..143
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 104..114
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 125..135
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT COMPBIAS 7..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 104..135
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 114..125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 151 AA; 17318 MW; 94366CAED71D7455 CRC64;
MEKPSPTRRQ TSSLSTISNG MTMTNDNRDT TNTNSGSTSS NNSQPSSSST PPAASGPVTD
RTKVNYVPKS DDPSSFQYYP DDPENPVNKY KFALKADSQY YDPCEESSKL SFQCLERNDY
DRSKCQEYFD AYRECKKQWL TARRKNRQQW E
