COX2_HUMAN
ID COX2_HUMAN Reviewed; 227 AA.
AC P00403; Q37526;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 220.
DE RecName: Full=Cytochrome c oxidase subunit 2;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome c oxidase polypeptide II;
GN Name=MT-CO2;
GN Synonyms=COII, COX2 {ECO:0000303|PubMed:29154948}, COXII, MTCO2;
OS Homo sapiens (Human).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=7219534; DOI=10.1038/290457a0;
RA Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R.,
RA Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H.,
RA Smith A.J.H., Staden R., Young I.G.;
RT "Sequence and organization of the human mitochondrial genome.";
RL Nature 290:457-465(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2550900; DOI=10.1093/nar/17.16.6734;
RA Power M.D., Kiefer M.C., Barr P.J., Reeves R.;
RT "Nucleotide sequence of human mitochondrial cytochrome c oxidase II cDNA.";
RL Nucleic Acids Res. 17:6734-6734(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=226894; DOI=10.1038/282189a0;
RA Barrell B.G., Bankier A.T., Drouin J.;
RT "A different genetic code in human mitochondria.";
RL Nature 282:189-194(1979).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Placenta;
RX PubMed=7530363; DOI=10.1073/pnas.92.2.532;
RA Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
RT "Recent African origin of modern humans revealed by complete sequences of
RT hominoid mitochondrial DNAs.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-30 AND THR-148.
RX PubMed=8277847; DOI=10.1093/oxfordjournals.molbev.a040068;
RA Ruvolo M., Zehr S., von Dornum M., Pan D., Chang B., Lin J.;
RT "Mitochondrial COII sequences and modern human origins.";
RL Mol. Biol. Evol. 10:1115-1135(1993).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12949126; DOI=10.1093/molbev/msg230;
RA Moilanen J.S., Finnila S., Majamaa K.;
RT "Lineage-specific selection in human mtDNA: lack of polymorphisms in a
RT segment of MTND5 gene in haplogroup J.";
RL Mol. Biol. Evol. 20:2132-2142(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11130070; DOI=10.1038/35047064;
RA Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.;
RT "Mitochondrial genome variation and the origin of modern humans.";
RL Nature 408:708-713(2000).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12840039; DOI=10.1101/gr.686603;
RA Ingman M., Gyllensten U.;
RT "Mitochondrial genome variation and evolutionary history of Australian and
RT New Guinean aborigines.";
RL Genome Res. 13:1600-1606(2003).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14760490; DOI=10.1007/s00414-004-0427-6;
RA Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T.,
RA Irwin J.A., Parsons T.J.;
RT "Single nucleotide polymorphisms over the entire mtDNA genome that increase
RT the power of forensic testing in Caucasians.";
RL Int. J. Legal Med. 118:137-146(2004).
RN [10]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-227.
RC TISSUE=Endometrial adenocarcinoma;
RA Swanson K.V., Griffiss J.;
RT "Gonococcal microcolony formation on HEC-1-B cells alters selective
RT mitochondrial transcripts.";
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 42-227.
RC TISSUE=Fetal liver;
RA Dmitrenko V.V., Kavsan V.M.;
RT "Nucleotide sequence of mitochondrial cytochrome C oxidase II from human
RT fetal liver.";
RL Submitted (SEP-1990) to the EMBL/GenBank/DDBJ databases.
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [13]
RP INTERACTION WITH COX20.
RX PubMed=23125284; DOI=10.1093/hmg/dds473;
RA Szklarczyk R., Wanschers B.F., Nijtmans L.G., Rodenburg R.J., Zschocke J.,
RA Dikow N., van den Brand M.A., Hendriks-Franssen M.G., Gilissen C.,
RA Veltman J.A., Nooteboom M., Koopman W.J., Willems P.H., Smeitink J.A.,
RA Huynen M.A., van den Heuvel L.P.;
RT "A mutation in the FAM36A gene, the human ortholog of COX20, impairs
RT cytochrome c oxidase assembly and is associated with ataxia and muscle
RT hypotonia.";
RL Hum. Mol. Genet. 22:656-667(2013).
RN [14]
RP INTERACTION WITH COX20.
RX PubMed=24403053; DOI=10.1093/hmg/ddu003;
RA Bourens M., Boulet A., Leary S.C., Barrientos A.;
RT "Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the
RT assembly of cytochrome c oxidase.";
RL Hum. Mol. Genet. 23:2901-2913(2014).
RN [15]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [16]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [17]
RP IDENTIFICATION IN A COMPLEX WITH TMEM177; COA6; COX20; COX18; SCO1 AND
RP SCO2, AND INTERACTION WITH TMEM177 AND COX20.
RX PubMed=29154948; DOI=10.1016/j.bbamcr.2017.11.010;
RA Lorenzi I., Oeljeklaus S., Aich A., Ronsoer C., Callegari S., Dudek J.,
RA Warscheid B., Dennerlein S., Rehling P.;
RT "The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.";
RL Biochim. Biophys. Acta 1865:323-333(2017).
RN [18]
RP INTERACTION WITH COX20.
RX PubMed=28330871; DOI=10.1074/jbc.m117.778514;
RA Bourens M., Barrientos A.;
RT "Human mitochondrial cytochrome c oxidase assembly factor COX18 acts
RT transiently as a membrane insertase within the subunit 2 maturation
RT module.";
RL J. Biol. Chem. 292:7774-7783(2017).
RN [19]
RP INTERACTION WITH COX16.
RX PubMed=29355485; DOI=10.1016/j.bbabio.2018.01.004;
RA Cerqua C., Morbidoni V., Desbats M.A., Doimo M., Frasson C., Sacconi S.,
RA Baldoin M.C., Sartori G., Basso G., Salviati L., Trevisson E.;
RT "COX16 is required for assembly of cytochrome c oxidase in human cells and
RT is involved in copper delivery to COX2.";
RL Biochim. Biophys. Acta 1859:244-252(2018).
RN [20]
RP INTERACTION WITH COX16.
RX PubMed=29381136; DOI=10.7554/elife.32572;
RA Aich A., Wang C., Chowdhury A., Ronsoer C., Pacheu-Grau D.,
RA Richter-Dennerlein R., Dennerlein S., Rehling P.;
RT "COX16 promotes COX2 metallation and assembly during respiratory complex IV
RT biogenesis.";
RL Elife 7:0-0(2018).
RN [21]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.90 ANGSTROMS), AND SUBUNIT.
RX PubMed=28844695; DOI=10.1016/j.cell.2017.07.050;
RA Guo R., Zong S., Wu M., Gu J., Yang M.;
RT "Architecture of human mitochondrial respiratory megacomplex I2III2IV2.";
RL Cell 170:1247-1257(2017).
RN [22]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS).
RX PubMed=30030519; DOI=10.1038/s41422-018-0071-1;
RA Zong S., Wu M., Gu J., Liu T., Guo R., Yang M.;
RT "Structure of the intact 14-subunit human cytochrome c oxidase.";
RL Cell Res. 28:1026-1034(2018).
RN [23]
RP VARIANTS ALA-11; PRO-123 AND MET-187.
RX PubMed=1757091; DOI=10.1007/bf00206061;
RA Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R.,
RA Utthanaphol P., Byrne E.;
RT "Normal variants of human mitochondrial DNA and translation products: the
RT building of a reference data base.";
RL Hum. Genet. 88:139-145(1991).
RN [24]
RP VARIANT COLORECTAL CANCER MET-142.
RX PubMed=9806551; DOI=10.1038/3108;
RA Polyak K., Li Y., Zhu H., Lengauer C., Willson J.K.V., Markowitz S.D.,
RA Trush M.A., Kinzler K.W., Vogelstein B.;
RT "Somatic mutations of the mitochondrial genome in human colorectal
RT tumours.";
RL Nat. Genet. 20:291-293(1998).
RN [25]
RP VARIANT MT-C4D LYS-29, AND CHARACTERIZATION OF VARIANT MT-C4D LYS-29.
RX PubMed=10486321; DOI=10.1086/302590;
RA Rahman S., Taanman J.-W., Cooper J.M., Nelson I., Hargreaves I.,
RA Meunier B., Hanna M.G., Garcia J.J., Capaldi R.A., Lake B.D., Leonard J.V.,
RA Schapira A.H.V.;
RT "A missense mutation of cytochrome oxidase subunit II causes defective
RT assembly and myopathy.";
RL Am. J. Hum. Genet. 65:1030-1039(1999).
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. The respiratory chain contains 3 multisubunit
CC complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC transfer electrons derived from NADH and succinate to molecular oxygen,
CC creating an electrochemical gradient over the inner membrane that
CC drives transmembrane transport and the ATP synthase. Cytochrome c
CC oxidase is the component of the respiratory chain that catalyzes the
CC reduction of oxygen to water. Electrons originating from reduced
CC cytochrome c in the intermembrane space (IMS) are transferred via the
CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC to the active site in subunit 1, a binuclear center (BNC) formed by
CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC water molecules using 4 electrons from cytochrome c in the IMS and 4
CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00410}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC Evidence={ECO:0000250|UniProtKB:P00410};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11437;
CC Evidence={ECO:0000250|UniProtKB:P00410};
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000269|PubMed:30030519};
CC Note=Binds a dinuclear copper A center per subunit.
CC {ECO:0000269|PubMed:30030519};
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of 14 subunits. The complex is composed of
CC a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or
CC COX4I2), COX5A, COX5B, COX6A1 (or COX6A2), COX6B1 (or COX6B2), COX6C,
CC COX7A2 (or COX7A1), COX7B, COX7C, COX8A and NDUFA4, which are encoded
CC in the nuclear genome (PubMed:30030519). The complex exists as a
CC monomer or a dimer and forms supercomplexes (SCs) in the inner
CC mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I,
CC CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex,
CC complex III, CIII), resulting in different assemblies (supercomplex
CC SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:28844695).
CC Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2
CC (PubMed:29154948). Interacts with TMEM177 in a COX20-dependent manner
CC (PubMed:29154948). Interacts with COX20 (PubMed:23125284,
CC PubMed:24403053, PubMed:28330871, PubMed:29154948). Interacts with
CC COX16 (PubMed:29355485, PubMed:29381136). {ECO:0000269|PubMed:23125284,
CC ECO:0000269|PubMed:24403053, ECO:0000269|PubMed:28330871,
CC ECO:0000269|PubMed:28844695, ECO:0000269|PubMed:29154948,
CC ECO:0000269|PubMed:29355485, ECO:0000269|PubMed:29381136,
CC ECO:0000269|PubMed:30030519}.
CC -!- INTERACTION:
CC P00403; Q9NZ94-2: NLGN3; NbExp=4; IntAct=EBI-2105756, EBI-16423037;
CC P00403; P49281-3: SLC11A2; NbExp=2; IntAct=EBI-2105756, EBI-10828817;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:30030519}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:30030519}.
CC -!- DISEASE: Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A
CC disorder of the mitochondrial respiratory chain with heterogeneous
CC clinical manifestations, ranging from isolated myopathy to severe
CC multisystem disease affecting several tissues and organs. Features
CC include hypertrophic cardiomyopathy, hepatomegaly and liver
CC dysfunction, hypotonia, muscle weakness, exercise intolerance,
CC developmental delay, delayed motor development and intellectual
CC disability. Some affected individuals manifest a fatal hypertrophic
CC cardiomyopathy resulting in neonatal death. A subset of patients
CC manifest Leigh syndrome. {ECO:0000269|PubMed:10486321}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
CC {ECO:0000305}.
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DR EMBL; V00662; CAA24029.1; -; Genomic_DNA.
DR EMBL; J01415; AAB58946.1; -; Genomic_DNA.
DR EMBL; X15759; CAA33766.1; -; mRNA.
DR EMBL; M25171; AAA31850.1; -; Genomic_DNA.
DR EMBL; D38112; BAA07293.1; -; Genomic_DNA.
DR EMBL; U12690; AAA20843.1; -; Genomic_DNA.
DR EMBL; U12691; AAA20844.1; -; Genomic_DNA.
DR EMBL; U12692; AAA20845.1; -; Genomic_DNA.
DR EMBL; U12693; AAA20846.1; -; Genomic_DNA.
DR EMBL; U12694; AAA20847.1; -; Genomic_DNA.
DR EMBL; AF004339; AAB63450.1; -; Genomic_DNA.
DR EMBL; AY339402; AAP89039.1; -; Genomic_DNA.
DR EMBL; AY339403; AAP89052.1; -; Genomic_DNA.
DR EMBL; AY339404; AAP89065.1; -; Genomic_DNA.
DR EMBL; AY339405; AAP89078.1; -; Genomic_DNA.
DR EMBL; AY339406; AAP89091.1; -; Genomic_DNA.
DR EMBL; AY339407; AAP89104.1; -; Genomic_DNA.
DR EMBL; AY339408; AAP89117.1; -; Genomic_DNA.
DR EMBL; AY339409; AAP89130.1; -; Genomic_DNA.
DR EMBL; AY339410; AAP89143.1; -; Genomic_DNA.
DR EMBL; AY339411; AAP89156.1; -; Genomic_DNA.
DR EMBL; AY339412; AAP89169.1; -; Genomic_DNA.
DR EMBL; AY339413; AAP89182.1; -; Genomic_DNA.
DR EMBL; AY339414; AAP89195.1; -; Genomic_DNA.
DR EMBL; AY339415; AAP89208.1; -; Genomic_DNA.
DR EMBL; AY339416; AAP89221.1; -; Genomic_DNA.
DR EMBL; AY339417; AAP89234.1; -; Genomic_DNA.
DR EMBL; AY339418; AAP89247.1; -; Genomic_DNA.
DR EMBL; AY339419; AAP89260.1; -; Genomic_DNA.
DR EMBL; AY339420; AAP89273.1; -; Genomic_DNA.
DR EMBL; AY339421; AAP89286.1; -; Genomic_DNA.
DR EMBL; AY339422; AAP89299.1; -; Genomic_DNA.
DR EMBL; AY339423; AAP89312.1; -; Genomic_DNA.
DR EMBL; AY339424; AAP89325.1; -; Genomic_DNA.
DR EMBL; AY339425; AAP89338.1; -; Genomic_DNA.
DR EMBL; AY339426; AAP89351.1; -; Genomic_DNA.
DR EMBL; AY339427; AAP89364.1; -; Genomic_DNA.
DR EMBL; AY339428; AAP89377.1; -; Genomic_DNA.
DR EMBL; AY339429; AAP89390.1; -; Genomic_DNA.
DR EMBL; AY339430; AAP89403.1; -; Genomic_DNA.
DR EMBL; AY339431; AAP89416.1; -; Genomic_DNA.
DR EMBL; AY339432; AAP89429.1; -; Genomic_DNA.
DR EMBL; AY339433; AAP89442.1; -; Genomic_DNA.
DR EMBL; AY339434; AAP89455.1; -; Genomic_DNA.
DR EMBL; AY339435; AAP89468.1; -; Genomic_DNA.
DR EMBL; AY339436; AAP89481.1; -; Genomic_DNA.
DR EMBL; AY339437; AAP89494.1; -; Genomic_DNA.
DR EMBL; AY339438; AAP89507.1; -; Genomic_DNA.
DR EMBL; AY339439; AAP89520.1; -; Genomic_DNA.
DR EMBL; AY339440; AAP89533.1; -; Genomic_DNA.
DR EMBL; AY339441; AAP89546.1; -; Genomic_DNA.
DR EMBL; AY339442; AAP89559.1; -; Genomic_DNA.
DR EMBL; AY339443; AAP89572.1; -; Genomic_DNA.
DR EMBL; AY339444; AAP89585.1; -; Genomic_DNA.
DR EMBL; AY339445; AAP89598.1; -; Genomic_DNA.
DR EMBL; AY339446; AAP89611.1; -; Genomic_DNA.
DR EMBL; AY339447; AAP89624.1; -; Genomic_DNA.
DR EMBL; AY339448; AAP89637.1; -; Genomic_DNA.
DR EMBL; AY339449; AAP89650.1; -; Genomic_DNA.
DR EMBL; AY339450; AAP89663.1; -; Genomic_DNA.
DR EMBL; AY339451; AAP89676.1; -; Genomic_DNA.
DR EMBL; AY339452; AAP89689.1; -; Genomic_DNA.
DR EMBL; AY339453; AAP89702.1; -; Genomic_DNA.
DR EMBL; AY339454; AAP89715.1; -; Genomic_DNA.
DR EMBL; AY339455; AAP89728.1; -; Genomic_DNA.
DR EMBL; AY339456; AAP89741.1; -; Genomic_DNA.
DR EMBL; AY339457; AAP89754.1; -; Genomic_DNA.
DR EMBL; AY339458; AAP89767.1; -; Genomic_DNA.
DR EMBL; AY339459; AAP89780.1; -; Genomic_DNA.
DR EMBL; AY339460; AAP89793.1; -; Genomic_DNA.
DR EMBL; AY339461; AAP89806.1; -; Genomic_DNA.
DR EMBL; AY339462; AAP89819.1; -; Genomic_DNA.
DR EMBL; AY339463; AAP89832.1; -; Genomic_DNA.
DR EMBL; AY339464; AAP89845.1; -; Genomic_DNA.
DR EMBL; AY339465; AAP89858.1; -; Genomic_DNA.
DR EMBL; AY339466; AAP89871.1; -; Genomic_DNA.
DR EMBL; AY339467; AAP89884.1; -; Genomic_DNA.
DR EMBL; AY339468; AAP89897.1; -; Genomic_DNA.
DR EMBL; AY339469; AAP89910.1; -; Genomic_DNA.
DR EMBL; AY339470; AAP89923.1; -; Genomic_DNA.
DR EMBL; AY339471; AAP89936.1; -; Genomic_DNA.
DR EMBL; AY339472; AAP89949.1; -; Genomic_DNA.
DR EMBL; AY339473; AAP89962.1; -; Genomic_DNA.
DR EMBL; AY339474; AAP89975.1; -; Genomic_DNA.
DR EMBL; AY339475; AAP89988.1; -; Genomic_DNA.
DR EMBL; AY339476; AAP90001.1; -; Genomic_DNA.
DR EMBL; AY339477; AAP90014.1; -; Genomic_DNA.
DR EMBL; AY339478; AAP90027.1; -; Genomic_DNA.
DR EMBL; AY339479; AAP90040.1; -; Genomic_DNA.
DR EMBL; AY339480; AAP90053.1; -; Genomic_DNA.
DR EMBL; AY339481; AAP90066.1; -; Genomic_DNA.
DR EMBL; AY339482; AAP90079.1; -; Genomic_DNA.
DR EMBL; AY339483; AAP90092.1; -; Genomic_DNA.
DR EMBL; AY339484; AAP90105.1; -; Genomic_DNA.
DR EMBL; AY339485; AAP90118.1; -; Genomic_DNA.
DR EMBL; AY339486; AAP90131.1; -; Genomic_DNA.
DR EMBL; AY339487; AAP90144.1; -; Genomic_DNA.
DR EMBL; AY339488; AAP90157.1; -; Genomic_DNA.
DR EMBL; AY339489; AAP90170.1; -; Genomic_DNA.
DR EMBL; AY339490; AAP90183.1; -; Genomic_DNA.
DR EMBL; AY339492; AAP90209.1; -; Genomic_DNA.
DR EMBL; AY339493; AAP90222.1; -; Genomic_DNA.
DR EMBL; AY339494; AAP90235.1; -; Genomic_DNA.
DR EMBL; AY339495; AAP90248.1; -; Genomic_DNA.
DR EMBL; AY339496; AAP90261.1; -; Genomic_DNA.
DR EMBL; AY339498; AAP90287.1; -; Genomic_DNA.
DR EMBL; AY339499; AAP90300.1; -; Genomic_DNA.
DR EMBL; AY339500; AAP90313.1; -; Genomic_DNA.
DR EMBL; AY339501; AAP90326.1; -; Genomic_DNA.
DR EMBL; AY339502; AAP90339.1; -; Genomic_DNA.
DR EMBL; AY339503; AAP90352.1; -; Genomic_DNA.
DR EMBL; AY339504; AAP90365.1; -; Genomic_DNA.
DR EMBL; AY339505; AAP90378.1; -; Genomic_DNA.
DR EMBL; AY339506; AAP90391.1; -; Genomic_DNA.
DR EMBL; AY339507; AAP90404.1; -; Genomic_DNA.
DR EMBL; AY339508; AAP90417.1; -; Genomic_DNA.
DR EMBL; AY339509; AAP90430.1; -; Genomic_DNA.
DR EMBL; AY339510; AAP90443.1; -; Genomic_DNA.
DR EMBL; AY339511; AAP90456.1; -; Genomic_DNA.
DR EMBL; AY339512; AAP90469.1; -; Genomic_DNA.
DR EMBL; AY339513; AAP90482.1; -; Genomic_DNA.
DR EMBL; AY339514; AAP90495.1; -; Genomic_DNA.
DR EMBL; AY339515; AAP90508.1; -; Genomic_DNA.
DR EMBL; AY339516; AAP90521.1; -; Genomic_DNA.
DR EMBL; AY339517; AAP90534.1; -; Genomic_DNA.
DR EMBL; AY339518; AAP90547.1; -; Genomic_DNA.
DR EMBL; AY339519; AAP90560.1; -; Genomic_DNA.
DR EMBL; AY339520; AAP90573.1; -; Genomic_DNA.
DR EMBL; AY339521; AAP90586.1; -; Genomic_DNA.
DR EMBL; AY339522; AAP90599.1; -; Genomic_DNA.
DR EMBL; AY339523; AAP90612.1; -; Genomic_DNA.
DR EMBL; AY339524; AAP90625.1; -; Genomic_DNA.
DR EMBL; AY339525; AAP90638.1; -; Genomic_DNA.
DR EMBL; AY339526; AAP90651.1; -; Genomic_DNA.
DR EMBL; AY339527; AAP90664.1; -; Genomic_DNA.
DR EMBL; AY339528; AAP90677.1; -; Genomic_DNA.
DR EMBL; AY339529; AAP90690.1; -; Genomic_DNA.
DR EMBL; AY339530; AAP90703.1; -; Genomic_DNA.
DR EMBL; AY339531; AAP90716.1; -; Genomic_DNA.
DR EMBL; AY339532; AAP90729.1; -; Genomic_DNA.
DR EMBL; AY339533; AAP90742.1; -; Genomic_DNA.
DR EMBL; AY339534; AAP90755.1; -; Genomic_DNA.
DR EMBL; AY339535; AAP90768.1; -; Genomic_DNA.
DR EMBL; AY339536; AAP90781.1; -; Genomic_DNA.
DR EMBL; AY339537; AAP90794.1; -; Genomic_DNA.
DR EMBL; AY339538; AAP90807.1; -; Genomic_DNA.
DR EMBL; AY339539; AAP90820.1; -; Genomic_DNA.
DR EMBL; AY339540; AAP90833.1; -; Genomic_DNA.
DR EMBL; AY339541; AAP90846.1; -; Genomic_DNA.
DR EMBL; AY339543; AAP90872.1; -; Genomic_DNA.
DR EMBL; AY339544; AAP90885.1; -; Genomic_DNA.
DR EMBL; AY339545; AAP90898.1; -; Genomic_DNA.
DR EMBL; AY339546; AAP90911.1; -; Genomic_DNA.
DR EMBL; AY339547; AAP90924.1; -; Genomic_DNA.
DR EMBL; AY339548; AAP90937.1; -; Genomic_DNA.
DR EMBL; AY339549; AAP90950.1; -; Genomic_DNA.
DR EMBL; AY339550; AAP90963.1; -; Genomic_DNA.
DR EMBL; AY339551; AAP90976.1; -; Genomic_DNA.
DR EMBL; AY339552; AAP90989.1; -; Genomic_DNA.
DR EMBL; AY339553; AAP91002.1; -; Genomic_DNA.
DR EMBL; AY339555; AAP91028.1; -; Genomic_DNA.
DR EMBL; AY339556; AAP91041.1; -; Genomic_DNA.
DR EMBL; AY339557; AAP91054.1; -; Genomic_DNA.
DR EMBL; AY339558; AAP91067.1; -; Genomic_DNA.
DR EMBL; AY339559; AAP91080.1; -; Genomic_DNA.
DR EMBL; AY339560; AAP91093.1; -; Genomic_DNA.
DR EMBL; AY339561; AAP91106.1; -; Genomic_DNA.
DR EMBL; AY339562; AAP91119.1; -; Genomic_DNA.
DR EMBL; AY339563; AAP91132.1; -; Genomic_DNA.
DR EMBL; AY339564; AAP91145.1; -; Genomic_DNA.
DR EMBL; AY339565; AAP91158.1; -; Genomic_DNA.
DR EMBL; AY339566; AAP91171.1; -; Genomic_DNA.
DR EMBL; AY339567; AAP91184.1; -; Genomic_DNA.
DR EMBL; AY339568; AAP91197.1; -; Genomic_DNA.
DR EMBL; AY339569; AAP91210.1; -; Genomic_DNA.
DR EMBL; AY339570; AAP91223.1; -; Genomic_DNA.
DR EMBL; AY339571; AAP91236.1; -; Genomic_DNA.
DR EMBL; AY339572; AAP91249.1; -; Genomic_DNA.
DR EMBL; AY339573; AAP91262.1; -; Genomic_DNA.
DR EMBL; AY339574; AAP91275.1; -; Genomic_DNA.
DR EMBL; AY339575; AAP91288.1; -; Genomic_DNA.
DR EMBL; AY339576; AAP91301.1; -; Genomic_DNA.
DR EMBL; AY339577; AAP91314.1; -; Genomic_DNA.
DR EMBL; AY339578; AAP91327.1; -; Genomic_DNA.
DR EMBL; AY339579; AAP91340.1; -; Genomic_DNA.
DR EMBL; AY339580; AAP91353.1; -; Genomic_DNA.
DR EMBL; AY339581; AAP91366.1; -; Genomic_DNA.
DR EMBL; AY339582; AAP91379.1; -; Genomic_DNA.
DR EMBL; AY339583; AAP91392.1; -; Genomic_DNA.
DR EMBL; AY339584; AAP91405.1; -; Genomic_DNA.
DR EMBL; AY339585; AAP91418.1; -; Genomic_DNA.
DR EMBL; AY339586; AAP91431.1; -; Genomic_DNA.
DR EMBL; AY339587; AAP91444.1; -; Genomic_DNA.
DR EMBL; AY339588; AAP91457.1; -; Genomic_DNA.
DR EMBL; AY339589; AAP91470.1; -; Genomic_DNA.
DR EMBL; AY339590; AAP91483.1; -; Genomic_DNA.
DR EMBL; AY339591; AAP91496.1; -; Genomic_DNA.
DR EMBL; AY339592; AAP91509.1; -; Genomic_DNA.
DR EMBL; AY339593; AAP91522.1; -; Genomic_DNA.
DR EMBL; AF346963; AAK17210.1; -; Genomic_DNA.
DR EMBL; AF346964; AAK17223.1; -; Genomic_DNA.
DR EMBL; AF346965; AAK17236.1; -; Genomic_DNA.
DR EMBL; AF346966; AAK17249.1; -; Genomic_DNA.
DR EMBL; AF346967; AAK17262.1; -; Genomic_DNA.
DR EMBL; AF346970; AAK17301.1; -; Genomic_DNA.
DR EMBL; AF346972; AAK17327.1; -; Genomic_DNA.
DR EMBL; AF346973; AAK17340.1; -; Genomic_DNA.
DR EMBL; AF346974; AAK17353.1; -; Genomic_DNA.
DR EMBL; AF346975; AAK17366.1; -; Genomic_DNA.
DR EMBL; AF346976; AAK17379.1; -; Genomic_DNA.
DR EMBL; AF346977; AAK17392.1; -; Genomic_DNA.
DR EMBL; AF346978; AAK17405.1; -; Genomic_DNA.
DR EMBL; AF346979; AAK17418.1; -; Genomic_DNA.
DR EMBL; AF346980; AAK17431.1; -; Genomic_DNA.
DR EMBL; AF346981; AAK17444.1; -; Genomic_DNA.
DR EMBL; AF346982; AAK17457.1; -; Genomic_DNA.
DR EMBL; AF346983; AAK17470.1; -; Genomic_DNA.
DR EMBL; AF346984; AAK17483.1; -; Genomic_DNA.
DR EMBL; AF346985; AAK17496.1; -; Genomic_DNA.
DR EMBL; AF346986; AAK17509.1; -; Genomic_DNA.
DR EMBL; AF346988; AAK17535.1; -; Genomic_DNA.
DR EMBL; AF346989; AAK17548.1; -; Genomic_DNA.
DR EMBL; AF346990; AAK17561.1; -; Genomic_DNA.
DR EMBL; AF346991; AAK17574.1; -; Genomic_DNA.
DR EMBL; AF346993; AAK17600.1; -; Genomic_DNA.
DR EMBL; AF346994; AAK17613.1; -; Genomic_DNA.
DR EMBL; AF346995; AAK17626.1; -; Genomic_DNA.
DR EMBL; AF346998; AAK17665.1; -; Genomic_DNA.
DR EMBL; AF346999; AAK17678.1; -; Genomic_DNA.
DR EMBL; AF347000; AAK17691.1; -; Genomic_DNA.
DR EMBL; AF347001; AAK17704.1; -; Genomic_DNA.
DR EMBL; AF347002; AAK17717.1; -; Genomic_DNA.
DR EMBL; AF347003; AAK17730.1; -; Genomic_DNA.
DR EMBL; AF347004; AAK17743.1; -; Genomic_DNA.
DR EMBL; AF347005; AAK17756.1; -; Genomic_DNA.
DR EMBL; AF347006; AAK17769.1; -; Genomic_DNA.
DR EMBL; AF347007; AAK17782.1; -; Genomic_DNA.
DR EMBL; AF347009; AAK17808.1; -; Genomic_DNA.
DR EMBL; AF347010; AAK17821.1; -; Genomic_DNA.
DR EMBL; AF347011; AAK17834.1; -; Genomic_DNA.
DR EMBL; AF347014; AAK17873.1; -; Genomic_DNA.
DR EMBL; AF347015; AAK17886.1; -; Genomic_DNA.
DR EMBL; AY289051; AAP47883.1; -; Genomic_DNA.
DR EMBL; AY289053; AAP47909.1; -; Genomic_DNA.
DR EMBL; AY289054; AAP47922.1; -; Genomic_DNA.
DR EMBL; AY289056; AAP47948.1; -; Genomic_DNA.
DR EMBL; AY289057; AAP47961.1; -; Genomic_DNA.
DR EMBL; AY289058; AAP47974.1; -; Genomic_DNA.
DR EMBL; AY289059; AAP47987.1; -; Genomic_DNA.
DR EMBL; AY289060; AAP48000.1; -; Genomic_DNA.
DR EMBL; AY289061; AAP48013.1; -; Genomic_DNA.
DR EMBL; AY289062; AAP48026.1; -; Genomic_DNA.
DR EMBL; AY289063; AAP48039.1; -; Genomic_DNA.
DR EMBL; AY289064; AAP48052.1; -; Genomic_DNA.
DR EMBL; AY289065; AAP48065.1; -; Genomic_DNA.
DR EMBL; AY289066; AAP48078.1; -; Genomic_DNA.
DR EMBL; AY289067; AAP48091.1; -; Genomic_DNA.
DR EMBL; AY289068; AAP48104.1; -; Genomic_DNA.
DR EMBL; AY289069; AAP48117.1; -; Genomic_DNA.
DR EMBL; AY289071; AAP48143.1; -; Genomic_DNA.
DR EMBL; AY289072; AAP48156.1; -; Genomic_DNA.
DR EMBL; AY289073; AAP48169.1; -; Genomic_DNA.
DR EMBL; AY289074; AAP48182.1; -; Genomic_DNA.
DR EMBL; AY289075; AAP48195.1; -; Genomic_DNA.
DR EMBL; AY289076; AAP48208.1; -; Genomic_DNA.
DR EMBL; AY289077; AAP48221.1; -; Genomic_DNA.
DR EMBL; AY289078; AAP48234.1; -; Genomic_DNA.
DR EMBL; AY289079; AAP48247.1; -; Genomic_DNA.
DR EMBL; AY289080; AAP48260.1; -; Genomic_DNA.
DR EMBL; AY289081; AAP48273.1; -; Genomic_DNA.
DR EMBL; AY289082; AAP48286.1; -; Genomic_DNA.
DR EMBL; AY289083; AAP48299.1; -; Genomic_DNA.
DR EMBL; AY289084; AAP48312.1; -; Genomic_DNA.
DR EMBL; AY289085; AAP48325.1; -; Genomic_DNA.
DR EMBL; AY289086; AAP48338.1; -; Genomic_DNA.
DR EMBL; AY289087; AAP48351.1; -; Genomic_DNA.
DR EMBL; AY289088; AAP48364.1; -; Genomic_DNA.
DR EMBL; AY289089; AAP48377.1; -; Genomic_DNA.
DR EMBL; AY289090; AAP48390.1; -; Genomic_DNA.
DR EMBL; AY289091; AAP48403.1; -; Genomic_DNA.
DR EMBL; AY289092; AAP48416.1; -; Genomic_DNA.
DR EMBL; AY289093; AAP48428.1; -; Genomic_DNA.
DR EMBL; AY289094; AAP48441.1; -; Genomic_DNA.
DR EMBL; AY289095; AAP48454.1; -; Genomic_DNA.
DR EMBL; AY289096; AAP48467.1; -; Genomic_DNA.
DR EMBL; AY289099; AAP48506.1; -; Genomic_DNA.
DR EMBL; AY289100; AAP48519.1; -; Genomic_DNA.
DR EMBL; AY289102; AAP48545.1; -; Genomic_DNA.
DR EMBL; AY495090; AAR92499.1; -; Genomic_DNA.
DR EMBL; AY495091; AAR92512.1; -; Genomic_DNA.
DR EMBL; AY495092; AAR92525.1; -; Genomic_DNA.
DR EMBL; AY495093; AAR92538.1; -; Genomic_DNA.
DR EMBL; AY495094; AAR92551.1; -; Genomic_DNA.
DR EMBL; AY495095; AAR92564.1; -; Genomic_DNA.
DR EMBL; AY495096; AAR92577.1; -; Genomic_DNA.
DR EMBL; AY495097; AAR92590.1; -; Genomic_DNA.
DR EMBL; AY495098; AAR92603.1; -; Genomic_DNA.
DR EMBL; AY495099; AAR92616.1; -; Genomic_DNA.
DR EMBL; AY495100; AAR92629.1; -; Genomic_DNA.
DR EMBL; AY495101; AAR92642.1; -; Genomic_DNA.
DR EMBL; AY495102; AAR92655.1; -; Genomic_DNA.
DR EMBL; AY495103; AAR92668.1; -; Genomic_DNA.
DR EMBL; AY495104; AAR92681.1; -; Genomic_DNA.
DR EMBL; AY495105; AAR92694.1; -; Genomic_DNA.
DR EMBL; AY495106; AAR92707.1; -; Genomic_DNA.
DR EMBL; AY495107; AAR92720.1; -; Genomic_DNA.
DR EMBL; AY495108; AAR92733.1; -; Genomic_DNA.
DR EMBL; AY495109; AAR92746.1; -; Genomic_DNA.
DR EMBL; AY495110; AAR92759.1; -; Genomic_DNA.
DR EMBL; AY495111; AAR92772.1; -; Genomic_DNA.
DR EMBL; AY495112; AAR92785.1; -; Genomic_DNA.
DR EMBL; AY495113; AAR92798.1; -; Genomic_DNA.
DR EMBL; AY495114; AAR92811.1; -; Genomic_DNA.
DR EMBL; AY495115; AAR92824.1; -; Genomic_DNA.
DR EMBL; AY495116; AAR92837.1; -; Genomic_DNA.
DR EMBL; AY495117; AAR92850.1; -; Genomic_DNA.
DR EMBL; AY495118; AAR92863.1; -; Genomic_DNA.
DR EMBL; AY495119; AAR92876.1; -; Genomic_DNA.
DR EMBL; AY495120; AAR92889.1; -; Genomic_DNA.
DR EMBL; AY495121; AAR92902.1; -; Genomic_DNA.
DR EMBL; AY495122; AAR92915.1; -; Genomic_DNA.
DR EMBL; AY495123; AAR92928.1; -; Genomic_DNA.
DR EMBL; AY495124; AAR92941.1; -; Genomic_DNA.
DR EMBL; AY495125; AAR92954.1; -; Genomic_DNA.
DR EMBL; AY495126; AAR92967.1; -; Genomic_DNA.
DR EMBL; AY495127; AAR92980.1; -; Genomic_DNA.
DR EMBL; AY495128; AAR92993.1; -; Genomic_DNA.
DR EMBL; AY495129; AAR93006.1; -; Genomic_DNA.
DR EMBL; AY495130; AAR93019.1; -; Genomic_DNA.
DR EMBL; AY495131; AAR93032.1; -; Genomic_DNA.
DR EMBL; AY495132; AAR93045.1; -; Genomic_DNA.
DR EMBL; AY495133; AAR93058.1; -; Genomic_DNA.
DR EMBL; AY495134; AAR93071.1; -; Genomic_DNA.
DR EMBL; AY495135; AAR93084.1; -; Genomic_DNA.
DR EMBL; AY495136; AAR93097.1; -; Genomic_DNA.
DR EMBL; AY495137; AAR93110.1; -; Genomic_DNA.
DR EMBL; AY495138; AAR93123.1; -; Genomic_DNA.
DR EMBL; AY495139; AAR93136.1; -; Genomic_DNA.
DR EMBL; AY495140; AAR93149.1; -; Genomic_DNA.
DR EMBL; AY495141; AAR93162.1; -; Genomic_DNA.
DR EMBL; AY495142; AAR93175.1; -; Genomic_DNA.
DR EMBL; AY495143; AAR93188.1; -; Genomic_DNA.
DR EMBL; AY495144; AAR93201.1; -; Genomic_DNA.
DR EMBL; AY495145; AAR93214.1; -; Genomic_DNA.
DR EMBL; AY495146; AAR93227.1; -; Genomic_DNA.
DR EMBL; AY495147; AAR93240.1; -; Genomic_DNA.
DR EMBL; AY495148; AAR93253.1; -; Genomic_DNA.
DR EMBL; AY495149; AAR93266.1; -; Genomic_DNA.
DR EMBL; AY495150; AAR93279.1; -; Genomic_DNA.
DR EMBL; AY495151; AAR93292.1; -; Genomic_DNA.
DR EMBL; AY495152; AAR93305.1; -; Genomic_DNA.
DR EMBL; AY495153; AAR93318.1; -; Genomic_DNA.
DR EMBL; AY495154; AAR93331.1; -; Genomic_DNA.
DR EMBL; AY495155; AAR93344.1; -; Genomic_DNA.
DR EMBL; AY495156; AAR93357.1; -; Genomic_DNA.
DR EMBL; AY495157; AAR93370.1; -; Genomic_DNA.
DR EMBL; AY495158; AAR93383.1; -; Genomic_DNA.
DR EMBL; AY495159; AAR93396.1; -; Genomic_DNA.
DR EMBL; AY495160; AAR93409.1; -; Genomic_DNA.
DR EMBL; AY495161; AAR93422.1; -; Genomic_DNA.
DR EMBL; AY495162; AAR93435.1; -; Genomic_DNA.
DR EMBL; AY495163; AAR93448.1; -; Genomic_DNA.
DR EMBL; AY495164; AAR93461.1; -; Genomic_DNA.
DR EMBL; AY495166; AAR93487.1; -; Genomic_DNA.
DR EMBL; AY495167; AAR93500.1; -; Genomic_DNA.
DR EMBL; AY495168; AAR93513.1; -; Genomic_DNA.
DR EMBL; AY495169; AAR93526.1; -; Genomic_DNA.
DR EMBL; AY495170; AAR93539.1; -; Genomic_DNA.
DR EMBL; AY495172; AAR93565.1; -; Genomic_DNA.
DR EMBL; AY495173; AAR93578.1; -; Genomic_DNA.
DR EMBL; AY495174; AAR93591.1; -; Genomic_DNA.
DR EMBL; AY495175; AAR93604.1; -; Genomic_DNA.
DR EMBL; AY495176; AAR93617.1; -; Genomic_DNA.
DR EMBL; AY495177; AAR93630.1; -; Genomic_DNA.
DR EMBL; AY495178; AAR93643.1; -; Genomic_DNA.
DR EMBL; AY495179; AAR93656.1; -; Genomic_DNA.
DR EMBL; AY495180; AAR93669.1; -; Genomic_DNA.
DR EMBL; AY495181; AAR93682.1; -; Genomic_DNA.
DR EMBL; AY495182; AAR93695.1; -; Genomic_DNA.
DR EMBL; AY495183; AAR93708.1; -; Genomic_DNA.
DR EMBL; AY495184; AAR93721.1; -; Genomic_DNA.
DR EMBL; AY495185; AAR93734.1; -; Genomic_DNA.
DR EMBL; AY495186; AAR93747.1; -; Genomic_DNA.
DR EMBL; AY495187; AAR93760.1; -; Genomic_DNA.
DR EMBL; AY495188; AAR93773.1; -; Genomic_DNA.
DR EMBL; AY495189; AAR93786.1; -; Genomic_DNA.
DR EMBL; AY495190; AAR93799.1; -; Genomic_DNA.
DR EMBL; AY495191; AAR93812.1; -; Genomic_DNA.
DR EMBL; AY495192; AAR93825.1; -; Genomic_DNA.
DR EMBL; AY495193; AAR93838.1; -; Genomic_DNA.
DR EMBL; AY495194; AAR93851.1; -; Genomic_DNA.
DR EMBL; AY495195; AAR93864.1; -; Genomic_DNA.
DR EMBL; AY495196; AAR93877.1; -; Genomic_DNA.
DR EMBL; AY495197; AAR93890.1; -; Genomic_DNA.
DR EMBL; AY495198; AAR93903.1; -; Genomic_DNA.
DR EMBL; AY495199; AAR93916.1; -; Genomic_DNA.
DR EMBL; AY495200; AAR93929.1; -; Genomic_DNA.
DR EMBL; AY495201; AAR93942.1; -; Genomic_DNA.
DR EMBL; AY495202; AAR93955.1; -; Genomic_DNA.
DR EMBL; AY495203; AAR93968.1; -; Genomic_DNA.
DR EMBL; AY495204; AAR93981.1; -; Genomic_DNA.
DR EMBL; AY495205; AAR93994.1; -; Genomic_DNA.
DR EMBL; AY495206; AAR94007.1; -; Genomic_DNA.
DR EMBL; AY495207; AAR94020.1; -; Genomic_DNA.
DR EMBL; AY495208; AAR94033.1; -; Genomic_DNA.
DR EMBL; AY495209; AAR94046.1; -; Genomic_DNA.
DR EMBL; AY495210; AAR94059.1; -; Genomic_DNA.
DR EMBL; AY495211; AAR94072.1; -; Genomic_DNA.
DR EMBL; AY495212; AAR94085.1; -; Genomic_DNA.
DR EMBL; AY495213; AAR94098.1; -; Genomic_DNA.
DR EMBL; AY495214; AAR94111.1; -; Genomic_DNA.
DR EMBL; AY495215; AAR94124.1; -; Genomic_DNA.
DR EMBL; AY495216; AAR94137.1; -; Genomic_DNA.
DR EMBL; AY495217; AAR94150.1; -; Genomic_DNA.
DR EMBL; AY495218; AAR94163.1; -; Genomic_DNA.
DR EMBL; AY495219; AAR94176.1; -; Genomic_DNA.
DR EMBL; AY495220; AAR94189.1; -; Genomic_DNA.
DR EMBL; AY495221; AAR94202.1; -; Genomic_DNA.
DR EMBL; AY495223; AAR94228.1; -; Genomic_DNA.
DR EMBL; AY495224; AAR94241.1; -; Genomic_DNA.
DR EMBL; AY495225; AAR94254.1; -; Genomic_DNA.
DR EMBL; AY495226; AAR94267.1; -; Genomic_DNA.
DR EMBL; AY495227; AAR94280.1; -; Genomic_DNA.
DR EMBL; AY495228; AAR94293.1; -; Genomic_DNA.
DR EMBL; AY495229; AAR94306.1; -; Genomic_DNA.
DR EMBL; AY495230; AAR94319.1; -; Genomic_DNA.
DR EMBL; AY495231; AAR94332.1; -; Genomic_DNA.
DR EMBL; AY495232; AAR94345.1; -; Genomic_DNA.
DR EMBL; AY495233; AAR94358.1; -; Genomic_DNA.
DR EMBL; AY495234; AAR94371.1; -; Genomic_DNA.
DR EMBL; AY495235; AAR94384.1; -; Genomic_DNA.
DR EMBL; AY495236; AAR94397.1; -; Genomic_DNA.
DR EMBL; AY495237; AAR94410.1; -; Genomic_DNA.
DR EMBL; AY495238; AAR94423.1; -; Genomic_DNA.
DR EMBL; AY495239; AAR94436.1; -; Genomic_DNA.
DR EMBL; AY495240; AAR94449.1; -; Genomic_DNA.
DR EMBL; AY495241; AAR94462.1; -; Genomic_DNA.
DR EMBL; AY495242; AAR94475.1; -; Genomic_DNA.
DR EMBL; AY495243; AAR94488.1; -; Genomic_DNA.
DR EMBL; AY495244; AAR94501.1; -; Genomic_DNA.
DR EMBL; AY495245; AAR94514.1; -; Genomic_DNA.
DR EMBL; AY495246; AAR94527.1; -; Genomic_DNA.
DR EMBL; AY495247; AAR94540.1; -; Genomic_DNA.
DR EMBL; AY495248; AAR94553.1; -; Genomic_DNA.
DR EMBL; AY495249; AAR94566.1; -; Genomic_DNA.
DR EMBL; AY495250; AAR94579.1; -; Genomic_DNA.
DR EMBL; AY495251; AAR94592.1; -; Genomic_DNA.
DR EMBL; AY495252; AAR94605.1; -; Genomic_DNA.
DR EMBL; AY495253; AAR94618.1; -; Genomic_DNA.
DR EMBL; AY495254; AAR94631.1; -; Genomic_DNA.
DR EMBL; AY495255; AAR94644.1; -; Genomic_DNA.
DR EMBL; AY495256; AAR94657.1; -; Genomic_DNA.
DR EMBL; AY495257; AAR94670.1; -; Genomic_DNA.
DR EMBL; AY495258; AAR94683.1; -; Genomic_DNA.
DR EMBL; AY495259; AAR94696.1; -; Genomic_DNA.
DR EMBL; AY495260; AAR94709.1; -; Genomic_DNA.
DR EMBL; AY495261; AAR94722.1; -; Genomic_DNA.
DR EMBL; AY495262; AAR94735.1; -; Genomic_DNA.
DR EMBL; AY495263; AAR94748.1; -; Genomic_DNA.
DR EMBL; AY495264; AAR94761.1; -; Genomic_DNA.
DR EMBL; AY495265; AAR94774.1; -; Genomic_DNA.
DR EMBL; AY495266; AAR94787.1; -; Genomic_DNA.
DR EMBL; AY495267; AAR94800.1; -; Genomic_DNA.
DR EMBL; AY495268; AAR94813.1; -; Genomic_DNA.
DR EMBL; AY495269; AAR94826.1; -; Genomic_DNA.
DR EMBL; AY495270; AAR94839.1; -; Genomic_DNA.
DR EMBL; AY495271; AAR94852.1; -; Genomic_DNA.
DR EMBL; AY495272; AAR94865.1; -; Genomic_DNA.
DR EMBL; AY495273; AAR94878.1; -; Genomic_DNA.
DR EMBL; AY495274; AAR94891.1; -; Genomic_DNA.
DR EMBL; AY495275; AAR94904.1; -; Genomic_DNA.
DR EMBL; AY495276; AAR94917.1; -; Genomic_DNA.
DR EMBL; AY495277; AAR94930.1; -; Genomic_DNA.
DR EMBL; AY495278; AAR94943.1; -; Genomic_DNA.
DR EMBL; AY495279; AAR94956.1; -; Genomic_DNA.
DR EMBL; AY495280; AAR94969.1; -; Genomic_DNA.
DR EMBL; AY495281; AAR94982.1; -; Genomic_DNA.
DR EMBL; AY495282; AAR94995.1; -; Genomic_DNA.
DR EMBL; AY495283; AAR95008.1; -; Genomic_DNA.
DR EMBL; AY495284; AAR95021.1; -; Genomic_DNA.
DR EMBL; AY495285; AAR95034.1; -; Genomic_DNA.
DR EMBL; AY495286; AAR95047.1; -; Genomic_DNA.
DR EMBL; AY495287; AAR95060.1; -; Genomic_DNA.
DR EMBL; AY495288; AAR95073.1; -; Genomic_DNA.
DR EMBL; AY495289; AAR95086.1; -; Genomic_DNA.
DR EMBL; AY495290; AAR95099.1; -; Genomic_DNA.
DR EMBL; AY495291; AAR95112.1; -; Genomic_DNA.
DR EMBL; AY495292; AAR95125.1; -; Genomic_DNA.
DR EMBL; AY495293; AAR95138.1; -; Genomic_DNA.
DR EMBL; AY495294; AAR95151.1; -; Genomic_DNA.
DR EMBL; AY495295; AAR95164.1; -; Genomic_DNA.
DR EMBL; AY495296; AAR95177.1; -; Genomic_DNA.
DR EMBL; AY495297; AAR95190.1; -; Genomic_DNA.
DR EMBL; AY495298; AAR95203.1; -; Genomic_DNA.
DR EMBL; AY495299; AAR95216.1; -; Genomic_DNA.
DR EMBL; AY495300; AAR95229.1; -; Genomic_DNA.
DR EMBL; AY495301; AAR95242.1; -; Genomic_DNA.
DR EMBL; AY495302; AAR95255.1; -; Genomic_DNA.
DR EMBL; AY495303; AAR95268.1; -; Genomic_DNA.
DR EMBL; AY495304; AAR95281.1; -; Genomic_DNA.
DR EMBL; AY495305; AAR95294.1; -; Genomic_DNA.
DR EMBL; AY495306; AAR95307.1; -; Genomic_DNA.
DR EMBL; AY495307; AAR95320.1; -; Genomic_DNA.
DR EMBL; AY495308; AAR95333.1; -; Genomic_DNA.
DR EMBL; AY495309; AAR95346.1; -; Genomic_DNA.
DR EMBL; AY495310; AAR95359.1; -; Genomic_DNA.
DR EMBL; AY495311; AAR95372.1; -; Genomic_DNA.
DR EMBL; AY495312; AAR95385.1; -; Genomic_DNA.
DR EMBL; AY495313; AAR95398.1; -; Genomic_DNA.
DR EMBL; AY495314; AAR95411.1; -; Genomic_DNA.
DR EMBL; AY495315; AAR95424.1; -; Genomic_DNA.
DR EMBL; AY495316; AAR95437.1; -; Genomic_DNA.
DR EMBL; AY495317; AAR95450.1; -; Genomic_DNA.
DR EMBL; AY495318; AAR95463.1; -; Genomic_DNA.
DR EMBL; AY495319; AAR95476.1; -; Genomic_DNA.
DR EMBL; AY495320; AAR95489.1; -; Genomic_DNA.
DR EMBL; AY495321; AAR95502.1; -; Genomic_DNA.
DR EMBL; AY495322; AAR95515.1; -; Genomic_DNA.
DR EMBL; AY495323; AAR95528.1; -; Genomic_DNA.
DR EMBL; AY495325; AAR95554.1; -; Genomic_DNA.
DR EMBL; AY495326; AAR95567.1; -; Genomic_DNA.
DR EMBL; AY495327; AAR95580.1; -; Genomic_DNA.
DR EMBL; AY495328; AAR95593.1; -; Genomic_DNA.
DR EMBL; AY495329; AAR95606.1; -; Genomic_DNA.
DR EMBL; AY495330; AAR95619.1; -; Genomic_DNA.
DR EMBL; X55654; CAA39187.1; -; mRNA.
DR PIR; A00472; OBHU2.
DR RefSeq; YP_003024029.1; NC_012920.1.
DR PDB; 3VRJ; X-ray; 1.90 A; C=46-55.
DR PDB; 5Z62; EM; 3.60 A; B=1-227.
DR PDBsum; 3VRJ; -.
DR PDBsum; 5Z62; -.
DR AlphaFoldDB; P00403; -.
DR SMR; P00403; -.
DR BioGRID; 110616; 178.
DR ComplexPortal; CPX-6123; Mitochondrial respiratory chain complex IV.
DR CORUM; P00403; -.
DR IntAct; P00403; 61.
DR MINT; P00403; -.
DR STRING; 9606.ENSP00000354876; -.
DR BindingDB; P00403; -.
DR ChEMBL; CHEMBL6174; -.
DR DrugBank; DB02659; Cholic Acid.
DR DrugBank; DB04464; N-Formylmethionine.
DR DrugBank; DB05412; Talmapimod.
DR DrugCentral; P00403; -.
DR TCDB; 3.D.4.11.1; the proton-translocating cytochrome oxidase (cox) superfamily.
DR GlyGen; P00403; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; P00403; -.
DR MetOSite; P00403; -.
DR PhosphoSitePlus; P00403; -.
DR SwissPalm; P00403; -.
DR BioMuta; MT-CO2; -.
DR DMDM; 117020; -.
DR EPD; P00403; -.
DR jPOST; P00403; -.
DR MassIVE; P00403; -.
DR PaxDb; P00403; -.
DR PeptideAtlas; P00403; -.
DR PRIDE; P00403; -.
DR ProteomicsDB; 51247; -.
DR TopDownProteomics; P00403; -.
DR Antibodypedia; 4262; 252 antibodies from 32 providers.
DR DNASU; 4513; -.
DR Ensembl; ENST00000361739.1; ENSP00000354876.1; ENSG00000198712.1.
DR GeneID; 4513; -.
DR KEGG; hsa:4513; -.
DR CTD; 4513; -.
DR DisGeNET; 4513; -.
DR GeneCards; MT-CO2; -.
DR GeneReviews; MT-CO2; -.
DR HGNC; HGNC:7421; MT-CO2.
DR HPA; ENSG00000198712; Tissue enhanced (brain).
DR MalaCards; MT-CO2; -.
DR MIM; 220110; phenotype.
DR MIM; 516040; gene.
DR neXtProt; NX_P00403; -.
DR OpenTargets; ENSG00000198712; -.
DR Orphanet; 254905; Isolated cytochrome C oxidase deficiency.
DR Orphanet; 550; MELAS.
DR PharmGKB; PA31227; -.
DR VEuPathDB; HostDB:ENSG00000198712; -.
DR eggNOG; KOG4767; Eukaryota.
DR GeneTree; ENSGT00390000017410; -.
DR HOGENOM; CLU_036876_2_3_1; -.
DR InParanoid; P00403; -.
DR OMA; WSYEYTD; -.
DR OrthoDB; 1432833at2759; -.
DR PhylomeDB; P00403; -.
DR TreeFam; TF344269; -.
DR BioCyc; MetaCyc:HS00027-MON; -.
DR PathwayCommons; P00403; -.
DR Reactome; R-HSA-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-HSA-611105; Respiratory electron transport.
DR Reactome; R-HSA-9707564; Cytoprotection by HMOX1.
DR SignaLink; P00403; -.
DR SIGNOR; P00403; -.
DR BioGRID-ORCS; 4513; 0 hits in 1 CRISPR screen.
DR ChiTaRS; MT-CO2; human.
DR GeneWiki; MT-CO2; -.
DR GenomeRNAi; 4513; -.
DR Pharos; P00403; Tchem.
DR PRO; PR:P00403; -.
DR Proteomes; UP000005640; Mitochondrion.
DR RNAct; P00403; protein.
DR Bgee; ENSG00000198712; Expressed in metanephros cortex and 93 other tissues.
DR ExpressionAtlas; P00403; baseline and differential.
DR Genevisible; P00403; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:CAFA.
DR GO; GO:0031966; C:mitochondrial membrane; IDA:ComplexPortal.
DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IPI:ComplexPortal.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0045277; C:respiratory chain complex IV; IDA:UniProtKB.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; NAS:UniProtKB.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IBA:GO_Central.
DR GO; GO:0045333; P:cellular respiration; IC:ComplexPortal.
DR GO; GO:0007595; P:lactation; IEA:Ensembl.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; ISS:FlyBase.
DR GO; GO:2001171; P:positive regulation of ATP biosynthetic process; IEA:Ensembl.
DR GO; GO:0010729; P:positive regulation of hydrogen peroxide biosynthetic process; IEA:Ensembl.
DR GO; GO:0010940; P:positive regulation of necrotic cell death; IEA:Ensembl.
DR GO; GO:0009409; P:response to cold; IEA:Ensembl.
DR CDD; cd13912; CcO_II_C; 1.
DR Gene3D; 1.10.287.90; -; 1.
DR Gene3D; 2.60.40.420; -; 1.
DR InterPro; IPR045187; CcO_II.
DR InterPro; IPR002429; CcO_II-like_C.
DR InterPro; IPR034210; CcO_II_C.
DR InterPro; IPR001505; Copper_CuA.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR014222; Cyt_c_oxidase_su2.
DR InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR InterPro; IPR036257; Cyt_c_oxidase_su2_TM_sf.
DR PANTHER; PTHR22888; PTHR22888; 1.
DR Pfam; PF00116; COX2; 1.
DR Pfam; PF02790; COX2_TM; 1.
DR SUPFAM; SSF49503; SSF49503; 1.
DR SUPFAM; SSF81464; SSF81464; 1.
DR TIGRFAMs; TIGR02866; CoxB; 1.
DR PROSITE; PS00078; COX2; 1.
DR PROSITE; PS50857; COX2_CUA; 1.
DR PROSITE; PS50999; COX2_TM; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Copper; Disease variant; Electron transport; Magnesium;
KW Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane;
KW Primary mitochondrial disease; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..227
FT /note="Cytochrome c oxidase subunit 2"
FT /id="PRO_0000183610"
FT TOPO_DOM 1..14
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000269|PubMed:30030519"
FT TRANSMEM 15..45
FT /note="Helical; Name=I"
FT /evidence="ECO:0000250|UniProtKB:P68530"
FT TOPO_DOM 46..59
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000269|PubMed:30030519"
FT TRANSMEM 60..87
FT /note="Helical; Name=II"
FT /evidence="ECO:0000250|UniProtKB:P68530"
FT TOPO_DOM 88..227
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000269|PubMed:30030519"
FT BINDING 161
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /ligand_label="A1"
FT /evidence="ECO:0000269|PubMed:30030519"
FT BINDING 196
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /ligand_label="A1"
FT /evidence="ECO:0000269|PubMed:30030519"
FT BINDING 196
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /ligand_label="A2"
FT /evidence="ECO:0000269|PubMed:30030519"
FT BINDING 198
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /ligand_label="A2"
FT /evidence="ECO:0000269|PubMed:30030519"
FT BINDING 198
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_note="ligand shared with MT-CO1"
FT /evidence="ECO:0000269|PubMed:30030519"
FT BINDING 200
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /ligand_label="A1"
FT /evidence="ECO:0000269|PubMed:30030519"
FT BINDING 200
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /ligand_label="A2"
FT /evidence="ECO:0000269|PubMed:30030519"
FT BINDING 204
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /ligand_label="A2"
FT /evidence="ECO:0000269|PubMed:30030519"
FT BINDING 207
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /ligand_label="A1"
FT /evidence="ECO:0000269|PubMed:30030519"
FT VARIANT 11
FT /note="D -> A"
FT /evidence="ECO:0000269|PubMed:1757091"
FT /id="VAR_008863"
FT VARIANT 29
FT /note="M -> K (in MT-C4D; affect the stability of the COX
FT complex; dbSNP:rs199474827)"
FT /evidence="ECO:0000269|PubMed:10486321"
FT /id="VAR_035085"
FT VARIANT 30
FT /note="I -> V (in dbSNP:rs1569484167)"
FT /evidence="ECO:0000269|PubMed:8277847"
FT /id="VAR_011344"
FT VARIANT 123
FT /note="L -> P"
FT /evidence="ECO:0000269|PubMed:1757091"
FT /id="VAR_008571"
FT VARIANT 142
FT /note="V -> M (in colorectal cancer; dbSNP:rs199474826)"
FT /evidence="ECO:0000269|PubMed:9806551"
FT /id="VAR_008390"
FT VARIANT 148
FT /note="A -> T (in dbSNP:rs1116904)"
FT /evidence="ECO:0000269|PubMed:8277847"
FT /id="VAR_011345"
FT VARIANT 187
FT /note="T -> M"
FT /evidence="ECO:0000269|PubMed:1757091"
FT /id="VAR_008572"
SQ SEQUENCE 227 AA; 25565 MW; 402A3145241DDEE6 CRC64;
MAHAAQVGLQ DATSPIMEEL ITFHDHALMI IFLICFLVLY ALFLTLTTKL TNTNISDAQE
METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI GHQWYWTYEY TDYGGLIFNS
YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI RMMITSQDVL HSWAVPTLGL KTDAIPGRLN
QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL
