ID   COX3_BACP3              Reviewed;         207 AA.
AC   Q03439;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Cytochrome c oxidase subunit 3;
DE            EC=7.1.1.9;
DE   AltName: Full=Cytochrome aa3 subunit 3;
DE   AltName: Full=Cytochrome c oxidase polypeptide III;
DE   AltName: Full=Oxidase aa(3) subunit 3;
GN   Name=ctaE; Synonyms=caaC;
OS   Bacillus sp. (strain PS3).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=2334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-16.
RX   PubMed=1964459; DOI=10.1093/oxfordjournals.jbchem.a123294;
RA   Ishizuka M., Machida K., Shimada S., Mogi A., Tsuchiya T., Ohmori T.,
RA   Souma Y., Gonda M., Sone N.;
RT   "Nucleotide sequence of the gene coding for four subunits of cytochrome c
RT   oxidase from the thermophilic bacterium PS3.";
RL   J. Biochem. 108:866-873(1990).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC         [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC       {ECO:0000305}.
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DR   EMBL; D13955; BAA03047.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q03439; -.
DR   SMR; Q03439; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR   CDD; cd02863; Ubiquinol_oxidase_III; 1.
DR   Gene3D; 1.20.120.80; -; 1.
DR   InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR   InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR   InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR   InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR   InterPro; IPR033946; Ubiquinol_oxase_su3_dom.
DR   PANTHER; PTHR11403; PTHR11403; 1.
DR   Pfam; PF00510; COX3; 1.
DR   SUPFAM; SSF81452; SSF81452; 1.
DR   PROSITE; PS50253; COX3; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Membrane; Translocase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..207
FT                   /note="Cytochrome c oxidase subunit 3"
FT                   /id="PRO_0000183876"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   207 AA;  23409 MW;  F398096AF02B5621 CRC64;
     MHAEEKLTAE TFPAAPERNA TLEGKNKFLG FWLFLGGETV LFASLFATYL ALKDKTNGGP
     SAEELFQMPV VFMATMLLLT SSLTSVYAIY HMKNFDFKKM QLWFGITVLL GAGFLGLEIY
     EFNEYVHEGH KFTTSAFASA FYTLVGTHGS HVAFGLLWIL TLMIRNAKRG LNLYNAPKFY
     VASLYWHFID VVWVFIFTVV YLMGMVG