COX3_BACSU
ID COX3_BACSU Reviewed; 207 AA.
AC P24012; O34333;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Cytochrome c oxidase subunit 3;
DE EC=7.1.1.9;
DE AltName: Full=Caa-3605 subunit 3;
DE AltName: Full=Cytochrome aa3 subunit 3;
DE AltName: Full=Cytochrome c oxidase polypeptide III;
DE AltName: Full=Oxidase aa(3) subunit 3;
GN Name=ctaE; OrderedLocusNames=BSU14910;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=1847686; DOI=10.1111/j.1432-1033.1991.tb15732.x;
RA Saraste M., Metso T., Nakari T., Jalli T., Lauraeus M., van der Oost J.;
RT "The Bacillus subtilis cytochrome-c oxidase. Variations on a conserved
RT protein theme.";
RL Eur. J. Biochem. 195:517-525(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Bertero M., Presecan E., Glaser P., Richou A., Danchin A.;
RT "Bacillus subtilis chromosomal region downstream nprE.";
RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC {ECO:0000305}.
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DR EMBL; X54140; CAA38078.1; -; Genomic_DNA.
DR EMBL; Z98682; CAB11344.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13364.1; -; Genomic_DNA.
DR PIR; F69609; F69609.
DR RefSeq; NP_389374.1; NC_000964.3.
DR RefSeq; WP_003232244.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; P24012; -.
DR SMR; P24012; -.
DR STRING; 224308.BSU14910; -.
DR TCDB; 3.D.4.4.1; the proton-translocating cytochrome oxidase (cox) superfamily.
DR PaxDb; P24012; -.
DR PRIDE; P24012; -.
DR EnsemblBacteria; CAB13364; CAB13364; BSU_14910.
DR GeneID; 935993; -.
DR KEGG; bsu:BSU14910; -.
DR PATRIC; fig|224308.179.peg.1626; -.
DR eggNOG; COG1845; Bacteria.
DR InParanoid; P24012; -.
DR OMA; FLDLLWV; -.
DR PhylomeDB; P24012; -.
DR BioCyc; BSUB:BSU14910-MON; -.
DR BioCyc; MetaCyc:BSU14910-MON; -.
DR SABIO-RK; P24012; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0009319; C:cytochrome o ubiquinol oxidase complex; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0009486; F:cytochrome bo3 ubiquinol oxidase activity; IBA:GO_Central.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0009055; F:electron transfer activity; IBA:GO_Central.
DR GO; GO:0015453; F:oxidoreduction-driven active transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0019646; P:aerobic electron transport chain; IBA:GO_Central.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR CDD; cd02863; Ubiquinol_oxidase_III; 1.
DR Gene3D; 1.20.120.80; -; 1.
DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR InterPro; IPR033946; Ubiquinol_oxase_su3_dom.
DR PANTHER; PTHR11403; PTHR11403; 1.
DR Pfam; PF00510; COX3; 1.
DR SUPFAM; SSF81452; SSF81452; 1.
DR PROSITE; PS50253; COX3; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..207
FT /note="Cytochrome c oxidase subunit 3"
FT /id="PRO_0000183877"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 26
FT /note="K -> N (in Ref. 1; CAA38078)"
FT /evidence="ECO:0000305"
FT CONFLICT 51..52
FT /note="LR -> AS (in Ref. 1; CAA38078)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 207 AA; 23266 MW; 9357E3DDAB137F12 CRC64;
MQVQEKFTAE TFPASPEKVT LEGKNKFLGF WLFLGGETVL FASLFATFLA LRNSNAGDPP
TTEMFDVTLV FIATMLLLTS SLTSVYAMYH MKNFSFGKMQ LWLGITILLG AGFLGLEIYE
FKHYTHEFGF TITSSALGSA FYTLVGTHGA HVAFGLMWIS TLMIRNAKRG LNLYTAPKFY
VASLYWHFID VVWVFIFTVV YLMGMVG
