ID   COX3_RICFE              Reviewed;         278 AA.
AC   Q4UKK0;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Probable cytochrome c oxidase subunit 3;
DE            EC=7.1.1.9;
DE   AltName: Full=Cytochrome aa3 subunit 3;
DE   AltName: Full=Cytochrome c oxidase polypeptide III;
GN   Name=ctaE; Synonyms=coxC; OrderedLocusNames=RF_1076;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC         [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000053; AAY61927.1; -; Genomic_DNA.
DR   RefSeq; WP_011271387.1; NC_007109.1.
DR   AlphaFoldDB; Q4UKK0; -.
DR   SMR; Q4UKK0; -.
DR   STRING; 315456.RF_1076; -.
DR   EnsemblBacteria; AAY61927; AAY61927; RF_1076.
DR   KEGG; rfe:RF_1076; -.
DR   eggNOG; COG1845; Bacteria.
DR   HOGENOM; CLU_044071_0_0_5; -.
DR   OMA; ALLWPDF; -.
DR   OrthoDB; 1502742at2; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR   CDD; cd01665; Cyt_c_Oxidase_III; 1.
DR   Gene3D; 1.20.120.80; -; 1.
DR   InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR   InterPro; IPR033945; Cyt_c_oxase_su3_dom.
DR   InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR   InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR   InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR   PANTHER; PTHR11403; PTHR11403; 1.
DR   Pfam; PF00510; COX3; 1.
DR   SUPFAM; SSF81452; SSF81452; 1.
DR   PROSITE; PS50253; COX3; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Translocase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..278
FT                   /note="Probable cytochrome c oxidase subunit 3"
FT                   /id="PRO_0000280890"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   278 AA;  31505 MW;  7CF5B3F4E7BDCAB9 CRC64;
     MNPNSHPITK SHLFHIVDPS PWPVLTSFAL LLLVIGGVSF MHGYKFNIYI LSAGVISVGY
     CLYSWWRDVV KEGIVEHQHT SPVRKGLQIG MALFILTEIV FFGVFFASFF KSSLSPVGLL
     DGVWVVKQGI WPPPTIKTFD PFDIPFINTL ILLLSGTTVT WAHYALEEKN QKDCVTALAL
     TILLGIFFTT MQAYEYYHAA FKFTDGIYAS NFYLATGFHG AHVIIGTIFL IVCYFRAKRG
     DFTTEGNGHL GFEFAAWYWH FVDVVWLFLF TFVYIFGS