COX3_RICPR
ID COX3_RICPR Reviewed; 278 AA.
AC Q9ZDX3;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Probable cytochrome c oxidase subunit 3;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome aa3 subunit 3;
DE AltName: Full=Cytochrome c oxidase polypeptide III;
GN Name=ctaE; Synonyms=coxC; OrderedLocusNames=RP191;
OS Rickettsia prowazekii (strain Madrid E).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX NCBI_TaxID=272947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Madrid E;
RX PubMed=9823893; DOI=10.1038/24094;
RA Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA Kurland C.G.;
RT "The genome sequence of Rickettsia prowazekii and the origin of
RT mitochondria.";
RL Nature 396:133-140(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC {ECO:0000305}.
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DR EMBL; AJ235270; CAA14657.1; -; Genomic_DNA.
DR PIR; B71730; B71730.
DR RefSeq; NP_220580.1; NC_000963.1.
DR RefSeq; WP_010886229.1; NC_000963.1.
DR AlphaFoldDB; Q9ZDX3; -.
DR SMR; Q9ZDX3; -.
DR STRING; 272947.RP191; -.
DR EnsemblBacteria; CAA14657; CAA14657; CAA14657.
DR GeneID; 57569318; -.
DR KEGG; rpr:RP191; -.
DR PATRIC; fig|272947.5.peg.198; -.
DR eggNOG; COG1845; Bacteria.
DR HOGENOM; CLU_044071_0_0_5; -.
DR OMA; ALLWPDF; -.
DR Proteomes; UP000002480; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR CDD; cd01665; Cyt_c_Oxidase_III; 1.
DR Gene3D; 1.20.120.80; -; 1.
DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR InterPro; IPR033945; Cyt_c_oxase_su3_dom.
DR InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR PANTHER; PTHR11403; PTHR11403; 1.
DR Pfam; PF00510; COX3; 1.
DR SUPFAM; SSF81452; SSF81452; 1.
DR PROSITE; PS50253; COX3; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..278
FT /note="Probable cytochrome c oxidase subunit 3"
FT /id="PRO_0000183887"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 278 AA; 31480 MW; A96D98054FA06151 CRC64;
MNPNSNSITK SHLFHIVNPS PWPILTSFAL LLLVIGGISS MHGYKFNMYI LSAGVISVIY
CLYSWWRDVV QEGIVEHQHT SPVRKGLKIG MVLFILTETV FFSVFFASFL KSSISPVGIL
DGVWVVKQGI WPPPTIKTFD PFDIPFINTL ILLLSGTTIT GAHYALEEKN QKDCVTALAF
TIVLGIFFTL MQVYEYYHAE FKFTDGIYAS NFYLATGFHG AHVVIGTIFL IVCYFRAKRG
DFTTEGNGHL GFEFAAWYWH FVDVVWLFLF TFVYILGS
