COX3_SOYBN
ID COX3_SOYBN Reviewed; 265 AA.
AC P14853; M1FN28;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Cytochrome c oxidase subunit 3;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome c oxidase polypeptide III;
GN Name=COX3; Synonyms=COXIII; ORFNames=GlmaxMp04;
OS Glycine max (Soybean) (Glycine hispida).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3847;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Williams 82;
RX PubMed=2562384; DOI=10.1007/bf00027319;
RA Grabau E.A., Gengenbach B.G.;
RT "Cytochrome oxidase subunit III gene from soybean mitochondria.";
RL Plant Mol. Biol. 13:595-597(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Aiganhuang; TISSUE=Etiolated seedling;
RX PubMed=23431381; DOI=10.1371/journal.pone.0056502;
RA Chang S., Wang Y., Lu J., Gai J., Li J., Chu P., Guan R., Zhao T.;
RT "The mitochondrial genome of soybean reveals complex genome structures and
RT gene evolution at intercellular and phylogenetic levels.";
RL PLoS ONE 8:E56502-E56502(2013).
RN [3]
RP RNA EDITING.
RC STRAIN=cv. Williams 82;
RX PubMed=1588598; DOI=10.1007/bf00162974;
RA Karlovsky P., Fartmann B.;
RT "Genetic code and phylogenetic origin of oomycetous mitochondria.";
RL J. Mol. Evol. 34:254-258(1992).
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. The respiratory chain contains 3 multisubunit
CC complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC transfer electrons derived from NADH and succinate to molecular oxygen,
CC creating an electrochemical gradient over the inner membrane that
CC drives transmembrane transport and the ATP synthase. Cytochrome c
CC oxidase is the component of the respiratory chain that catalyzes the
CC reduction of oxygen to water. Electrons originating from reduced
CC cytochrome c in the intermembrane space (IMS) are transferred via the
CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC to the active site in subunit 1, a binuclear center (BNC) formed by
CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC water molecules using 4 electrons from cytochrome c in the IMS and 4
CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00420}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC Evidence={ECO:0000250|UniProtKB:P00420};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11437;
CC Evidence={ECO:0000250|UniProtKB:P00420};
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of a catalytic core of 3 subunits and
CC several supernumerary subunits. The complex exists as a monomer or a
CC dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1
CC complex, complex III, CIII). {ECO:0000250|UniProtKB:P00420}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P00420}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P00420}.
CC -!- RNA EDITING: Modified_positions=102 {ECO:0000269|PubMed:1588598}, 130
CC {ECO:0000269|PubMed:1588598}, 252 {ECO:0000269|PubMed:1588598};
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC {ECO:0000305}.
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DR EMBL; X15131; CAA33227.1; ALT_SEQ; Genomic_DNA.
DR EMBL; JX463295; AFR34298.1; -; Genomic_DNA.
DR PIR; S07468; OTSY3M.
DR RefSeq; XP_006592610.1; XM_006592547.2.
DR RefSeq; YP_007516854.1; NC_020455.1.
DR AlphaFoldDB; P14853; -.
DR SMR; P14853; -.
DR STRING; 3847.GLYMA0405S00330.1; -.
DR PRIDE; P14853; -.
DR GeneID; 100780641; -.
DR GeneID; 15308561; -.
DR KEGG; gmx:100780641; -.
DR KEGG; gmx:15308561; -.
DR eggNOG; KOG4664; Eukaryota.
DR InParanoid; P14853; -.
DR OrthoDB; 1304563at2759; -.
DR Proteomes; UP000008827; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0009055; F:electron transfer activity; IBA:GO_Central.
DR GO; GO:0015453; F:oxidoreduction-driven active transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
DR CDD; cd01665; Cyt_c_Oxidase_III; 1.
DR Gene3D; 1.20.120.80; -; 1.
DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR InterPro; IPR033945; Cyt_c_oxase_su3_dom.
DR InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR PANTHER; PTHR11403; PTHR11403; 1.
DR Pfam; PF00510; COX3; 1.
DR SUPFAM; SSF81452; SSF81452; 1.
DR PROSITE; PS50253; COX3; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW RNA editing; Translocase; Transmembrane; Transmembrane helix.
FT CHAIN 1..265
FT /note="Cytochrome c oxidase subunit 3"
FT /id="PRO_0000183854"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 265 AA; 29690 MW; 066311899192AB0F CRC64;
MIESQRHSYH LVDPSPWPIS GSLGALATTV GGVMYMHSFQ GGATLLSLGL IFILYTMFVW
WRDVLRESTL EGHHTKVVQL GPRYGSIPFI VSEVMFLFAF FWASSHSSLA PTVEIGGIWP
PLGIWVLDPW EIPFLNTPIL LSSGAAVTWA HHAILAGKEK RAVYALVATV SLALVFTGFQ
GMEYYQAPFT ISDSIYGSTF FLATGFHGFH VIIGTLFLII CGIRQYLGHL TKEHHVGFEA
AAWYWHFVDV VWLFLFVSIY WWGGI
