COX3_SYNY3
ID COX3_SYNY3 Reviewed; 233 AA.
AC Q06475; P73262;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Cytochrome c oxidase subunit 3;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome aa3 subunit 3;
DE AltName: Full=Cytochrome c oxidase polypeptide III;
DE AltName: Full=Oxidase aa(3) subunit 3;
GN Name=ctaE; OrderedLocusNames=slr1138;
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC unclassified Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8387368;
RA Alge D., Peschek G.A.;
RT "Characterization of a cta/CDE operon-like genomic region encoding subunits
RT I-III of the cytochrome c oxidase of the cyanobacterium Synechocystis PCC
RT 6803.";
RL Biochem. Mol. Biol. Int. 29:511-525(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 3 family.
CC {ECO:0000305}.
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DR EMBL; X53746; CAA37778.1; -; Genomic_DNA.
DR EMBL; BA000022; BAA17290.1; -; Genomic_DNA.
DR PIR; S77443; S77443.
DR AlphaFoldDB; Q06475; -.
DR SMR; Q06475; -.
DR STRING; 1148.1652368; -.
DR PaxDb; Q06475; -.
DR EnsemblBacteria; BAA17290; BAA17290; BAA17290.
DR KEGG; syn:slr1138; -.
DR eggNOG; COG1845; Bacteria.
DR InParanoid; Q06475; -.
DR OMA; SIYWWGS; -.
DR PhylomeDB; Q06475; -.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0009055; F:electron transfer activity; IBA:GO_Central.
DR GO; GO:0015453; F:oxidoreduction-driven active transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0019646; P:aerobic electron transport chain; IEA:InterPro.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR Gene3D; 1.20.120.80; -; 1.
DR InterPro; IPR024791; Cyt_c/ubiquinol_Oxase_su3.
DR InterPro; IPR000298; Cyt_c_oxidase-like_su3.
DR InterPro; IPR035973; Cyt_c_oxidase_su3-like_sf.
DR InterPro; IPR013833; Cyt_c_oxidase_su3_a-hlx.
DR PANTHER; PTHR11403; PTHR11403; 1.
DR Pfam; PF00510; COX3; 1.
DR SUPFAM; SSF81452; SSF81452; 1.
DR PROSITE; PS50253; COX3; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..233
FT /note="Cytochrome c oxidase subunit 3"
FT /id="PRO_0000183891"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 1..13
FT /note="MTSPMGPTARDFW -> MARPPGGFL (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 114..117
FT /note="SFVM -> R (in Ref. 1; CAA37778)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 233 AA; 26083 MW; 720A8F794DE17F43 CRC64;
MTSPMGPTAR DFWQNSRNSA TIQRLIVSPM QTTALSSDLN STYTPGEAHG HHGHPDLRMF
GVVLFLVAES AIFLGLFTAY LIYRSVMPAW PPEGTPELEL LLPGVNSIIL ISSSFVMHKG
QAAIRNNDNA GLQKWFGITA AMGIIFLAGQ MYEYFHLEMG LTTNLFASCF YVLTGFHGLH
VTFGLLLILS VLWRSRQPGH YSRTSHFGVE AAELYWHFVD VVWIVLFILV YLL
