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COX41_RABIT
ID   COX41_RABIT             Reviewed;         169 AA.
AC   Q9TTT8;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Cytochrome c oxidase subunit 4 isoform 1, mitochondrial;
DE   AltName: Full=Cytochrome c oxidase polypeptide IV;
DE   AltName: Full=Cytochrome c oxidase subunit IV isoform 1;
DE            Short=COX IV-1;
DE   Flags: Precursor;
GN   Name=COX4I1; Synonyms=COX4, COXIV;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white;
RA   Wu X., Hudson A.P.;
RT   "Cloning and characterization of genes coxIV and coxVIa2 from the rabbit
RT   genome.";
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC       mitochondrial electron transport chain which drives oxidative
CC       phosphorylation. The respiratory chain contains 3 multisubunit
CC       complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC       cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC       CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC       transfer electrons derived from NADH and succinate to molecular oxygen,
CC       creating an electrochemical gradient over the inner membrane that
CC       drives transmembrane transport and the ATP synthase. Cytochrome c
CC       oxidase is the component of the respiratory chain that catalyzes the
CC       reduction of oxygen to water. Electrons originating from reduced
CC       cytochrome c in the intermembrane space (IMS) are transferred via the
CC       dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC       to the active site in subunit 1, a binuclear center (BNC) formed by
CC       heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC       water molecules using 4 electrons from cytochrome c in the IMS and 4
CC       protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC       {ECO:0000250|UniProtKB:P00424}.
CC   -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC       multisubunit enzyme composed of 14 subunits. The complex is composed of
CC       a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC       the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A,
CC       COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which
CC       are encoded in the nuclear genome. The complex exists as a monomer or a
CC       dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC       membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC       ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC       III, CIII), resulting in different assemblies (supercomplex
CC       SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity).
CC       Interacts with PHB2; the interaction decreases in absence of SPHK2 (By
CC       similarity). Interacts with AFG1L (By similarity). Interacts with
CC       ABCB7; this interaction allows the regulation of cellular iron
CC       homeostasis and cellular reactive oxygen species (ROS) levels in
CC       cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P00423,
CC       ECO:0000250|UniProtKB:P10888, ECO:0000250|UniProtKB:P13073,
CC       ECO:0000250|UniProtKB:P19783}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P00423}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P00423}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase IV family.
CC       {ECO:0000305}.
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DR   EMBL; AF198088; AAF13254.1; -; mRNA.
DR   RefSeq; NP_001164353.1; NM_001170882.1.
DR   AlphaFoldDB; Q9TTT8; -.
DR   SMR; Q9TTT8; -.
DR   STRING; 9986.ENSOCUP00000001489; -.
DR   iPTMnet; Q9TTT8; -.
DR   KEGG; ocu:100327269; -.
DR   eggNOG; KOG4075; Eukaryota.
DR   InParanoid; Q9TTT8; -.
DR   UniPathway; UPA00705; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro.
DR   GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IEA:InterPro.
DR   CDD; cd00922; Cyt_c_Oxidase_IV; 1.
DR   Gene3D; 1.10.442.10; -; 1.
DR   InterPro; IPR013288; Cyt_c_oxidase_su4.
DR   InterPro; IPR004203; Cyt_c_oxidase_su4_fam.
DR   InterPro; IPR036639; Cyt_c_oxidase_su4_sf.
DR   PANTHER; PTHR10707; PTHR10707; 1.
DR   Pfam; PF02936; COX4; 1.
DR   PRINTS; PR01873; CYTCOXIDASE4.
DR   SUPFAM; SSF81406; SSF81406; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Phosphoprotein; Reference proteome; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..22
FT                   /note="Mitochondrion"
FT   CHAIN           23..169
FT                   /note="Cytochrome c oxidase subunit 4 isoform 1,
FT                   mitochondrial"
FT                   /id="PRO_0000006087"
FT   TOPO_DOM        23..98
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:P00423"
FT   TRANSMEM        99..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:P00423"
FT   TOPO_DOM        125..169
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:P00423"
FT   MOD_RES         29
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P19783"
FT   MOD_RES         29
FT                   /note="N6-succinyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P19783"
FT   MOD_RES         53
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P13073"
FT   MOD_RES         56
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P10888"
FT   MOD_RES         60
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P13073"
FT   MOD_RES         60
FT                   /note="N6-succinyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P19783"
FT   MOD_RES         67
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P19783"
SQ   SEQUENCE   169 AA;  19599 MW;  0E5C08CF577FFB32 CRC64;
     MLPTRLLSFS GSRAISTSFC LRAHGSVVKS EDYALPSYVD RRDYPLPDVA HVKQLSAGQK
     ALKEKEKAPW GSLTRDEKVE LYRIQFNESF AEMNRGTNEW KTVVGTALFF IGFTALILIW
     EKHYVYGPIP HTFDKEWVAM QTKRMLDMKV SPIQGFSAKW DYNKNEWRK
 
 
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