COX42_RAT
ID COX42_RAT Reviewed; 172 AA.
AC Q91Y94;
DT 03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Cytochrome c oxidase subunit 4 isoform 2, mitochondrial;
DE AltName: Full=Cytochrome c oxidase subunit IV isoform 2;
DE Short=COX IV-2;
DE Flags: Precursor;
GN Name=Cox4i2; Synonyms=Cox4b;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11311561; DOI=10.1016/s0378-1119(01)00385-7;
RA Huettemann M., Kadenbach B., Grossman L.I.;
RT "Mammalian subunit IV isoforms of cytochrome c oxidase.";
RL Gene 267:111-123(2001).
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. The respiratory chain contains 3 multisubunit
CC complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC transfer electrons derived from NADH and succinate to molecular oxygen,
CC creating an electrochemical gradient over the inner membrane that
CC drives transmembrane transport and the ATP synthase. Cytochrome c
CC oxidase is the component of the respiratory chain that catalyzes the
CC reduction of oxygen to water. Electrons originating from reduced
CC cytochrome c in the intermembrane space (IMS) are transferred via the
CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC to the active site in subunit 1, a binuclear center (BNC) formed by
CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC water molecules using 4 electrons from cytochrome c in the IMS and 4
CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00424}.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000250|UniProtKB:P00424}.
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of 14 subunits. The complex is composed of
CC a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A,
CC COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which
CC are encoded in the nuclear genome. The complex exists as a monomer or a
CC dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC III, CIII), resulting in different assemblies (supercomplex
CC SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
CC {ECO:0000250|UniProtKB:P00423}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P00423}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P00423}.
CC -!- TISSUE SPECIFICITY: Highly expressed in lung.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase IV family.
CC {ECO:0000305}.
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DR EMBL; AF255347; AAK49191.1; -; mRNA.
DR RefSeq; NP_445924.1; NM_053472.1.
DR RefSeq; XP_006235342.1; XM_006235280.3.
DR RefSeq; XP_017447569.1; XM_017592080.1.
DR AlphaFoldDB; Q91Y94; -.
DR SMR; Q91Y94; -.
DR STRING; 10116.ENSRNOP00000010418; -.
DR iPTMnet; Q91Y94; -.
DR PhosphoSitePlus; Q91Y94; -.
DR jPOST; Q91Y94; -.
DR PaxDb; Q91Y94; -.
DR GeneID; 84683; -.
DR KEGG; rno:84683; -.
DR UCSC; RGD:69422; rat.
DR CTD; 84701; -.
DR RGD; 69422; Cox4i2.
DR VEuPathDB; HostDB:ENSRNOG00000007827; -.
DR eggNOG; KOG4075; Eukaryota.
DR HOGENOM; CLU_117340_1_1_1; -.
DR InParanoid; Q91Y94; -.
DR OMA; MLSRATW; -.
DR OrthoDB; 1591226at2759; -.
DR PhylomeDB; Q91Y94; -.
DR TreeFam; TF105061; -.
DR UniPathway; UPA00705; -.
DR PRO; PR:Q91Y94; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000007827; Expressed in heart and 19 other tissues.
DR Genevisible; Q91Y94; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; ISO:RGD.
DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IBA:GO_Central.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; ISO:RGD.
DR GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; ISO:RGD.
DR CDD; cd00922; Cyt_c_Oxidase_IV; 1.
DR Gene3D; 1.10.442.10; -; 1.
DR InterPro; IPR013288; Cyt_c_oxidase_su4.
DR InterPro; IPR004203; Cyt_c_oxidase_su4_fam.
DR InterPro; IPR036639; Cyt_c_oxidase_su4_sf.
DR PANTHER; PTHR10707; PTHR10707; 1.
DR Pfam; PF02936; COX4; 1.
DR PRINTS; PR01873; CYTCOXIDASE4.
DR SUPFAM; SSF81406; SSF81406; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..18
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 19..172
FT /note="Cytochrome c oxidase subunit 4 isoform 2,
FT mitochondrial"
FT /id="PRO_0000006091"
FT TOPO_DOM 19..101
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:P00423"
FT TRANSMEM 102..127
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:P00423"
FT TOPO_DOM 128..172
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:P00423"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 172 AA; 20170 MW; FBBF5527F83E7EF0 CRC64;
MFSRATRSLV MKTGGLRTQG THSPGSAASS SQRRMTPYVD CYAQRSYPMP DEPYCTELSE
EQRALKEKEK GSWAQLSQAE KVALYRLQFH ETFAEMNHRS NEWKTVMGCV FFFIGFTALV
IWWQRVYVFP KKVVTLTEER KAQQLQRLLD MKSNPIQGLS AHWDYEKKEW KK
