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COX4_ALKPO
ID   COX4_ALKPO              Reviewed;         114 AA.
AC   Q04452; D3FU47;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Cytochrome c oxidase subunit 4B;
DE            EC=7.1.1.9;
DE   AltName: Full=Cytochrome aa3 subunit 4B;
DE   AltName: Full=Cytochrome c oxidase polypeptide IVB;
GN   Name=ctaF; OrderedLocusNames=BpOF4_00900;
OS   Alkalihalophilus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4)
OS   (Bacillus pseudofirmus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalophilus.
OX   NCBI_TaxID=398511;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7678007; DOI=10.1016/s0021-9258(18)54205-8;
RA   Quirk P.G., Hicks D.B., Krulwich T.A.;
RT   "Cloning of the cta operon from alkaliphilic Bacillus firmus OF4 and
RT   characterization of the pH-regulated cytochrome caa3 oxidase it encodes.";
RL   J. Biol. Chem. 268:678-685(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-2126 / JCM 17055 / OF4;
RX   PubMed=21951522; DOI=10.1111/j.1462-2920.2011.02591.x;
RA   Janto B., Ahmed A., Ito M., Liu J., Hicks D.B., Pagni S., Fackelmayer O.J.,
RA   Smith T.A., Earl J., Elbourne L.D., Hassan K., Paulsen I.T., Kolsto A.B.,
RA   Tourasse N.J., Ehrlich G.D., Boissy R., Ivey D.M., Li G., Xue Y., Ma Y.,
RA   Hu F.Z., Krulwich T.A.;
RT   "Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that
RT   support the ability to grow in an external pH range from 7.5 to 11.4.";
RL   Environ. Microbiol. 13:3289-3309(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC         [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit 4
CC       family. {ECO:0000305}.
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DR   EMBL; M94110; AAA22367.1; -; Genomic_DNA.
DR   EMBL; CP001878; ADC48249.1; -; Genomic_DNA.
DR   RefSeq; WP_012959531.1; NC_013791.2.
DR   AlphaFoldDB; Q04452; -.
DR   SMR; Q04452; -.
DR   STRING; 398511.BpOF4_00900; -.
DR   EnsemblBacteria; ADC48249; ADC48249; BpOF4_00900.
DR   KEGG; bpf:BpOF4_00900; -.
DR   eggNOG; COG3125; Bacteria.
DR   HOGENOM; CLU_140945_3_0_9; -.
DR   OMA; YEEFSHW; -.
DR   OrthoDB; 2088013at2; -.
DR   Proteomes; UP000001544; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR005171; Cyt_c_oxidase_su4_prok.
DR   Pfam; PF03626; COX4_pro; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..114
FT                   /note="Cytochrome c oxidase subunit 4B"
FT                   /id="PRO_0000183900"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        32
FT                   /note="V -> A (in Ref. 1; AAA22367)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   114 AA;  13045 MW;  FEE7A03352BF648D CRC64;
     MADNLSQSFD KSAMTEEERR HIKKEIRKQI VVFALMIFLT LMSFMAVATD VIPRSFAIPF
     IFILAVIQFA LQLFFFMHMK DKDHGWANAF MISGIFITVP TIAALMLLLG VNKI
 
 
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