COX4_BACSU
ID COX4_BACSU Reviewed; 110 AA.
AC P24013;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Cytochrome c oxidase subunit 4B;
DE EC=7.1.1.9;
DE AltName: Full=Caa-3605 subunit 4B;
DE AltName: Full=Cytochrome aa3 subunit 4B;
DE AltName: Full=Cytochrome c oxidase polypeptide IVB;
GN Name=ctaF; OrderedLocusNames=BSU14920;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=1847686; DOI=10.1111/j.1432-1033.1991.tb15732.x;
RA Saraste M., Metso T., Nakari T., Jalli T., Lauraeus M., van der Oost J.;
RT "The Bacillus subtilis cytochrome-c oxidase. Variations on a conserved
RT protein theme.";
RL Eur. J. Biochem. 195:517-525(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Bertero M., Presecan E., Glaser P., Richou A., Danchin A.;
RT "Bacillus subtilis chromosomal region downstream nprE.";
RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit 4
CC family. {ECO:0000305}.
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DR EMBL; X54140; CAA38079.1; -; Genomic_DNA.
DR EMBL; Z98682; CAB11345.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13365.1; -; Genomic_DNA.
DR PIR; G69609; G69609.
DR RefSeq; NP_389375.1; NC_000964.3.
DR RefSeq; WP_003232242.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; P24013; -.
DR SMR; P24013; -.
DR STRING; 224308.BSU14920; -.
DR TCDB; 3.D.4.4.1; the proton-translocating cytochrome oxidase (cox) superfamily.
DR PaxDb; P24013; -.
DR EnsemblBacteria; CAB13365; CAB13365; BSU_14920.
DR GeneID; 936259; -.
DR KEGG; bsu:BSU14920; -.
DR PATRIC; fig|224308.179.peg.1627; -.
DR eggNOG; COG3125; Bacteria.
DR OMA; YEEFSHW; -.
DR BioCyc; BSUB:BSU14920-MON; -.
DR BioCyc; MetaCyc:BSU14920-MON; -.
DR SABIO-RK; P24013; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR InterPro; IPR014257; Cyt_c_oxidase_su4_bacillaceae.
DR InterPro; IPR005171; Cyt_c_oxidase_su4_prok.
DR Pfam; PF03626; COX4_pro; 1.
DR TIGRFAMs; TIGR02908; CoxD_Bacillus; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..110
FT /note="Cytochrome c oxidase subunit 4B"
FT /id="PRO_0000183902"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 110 AA; 12620 MW; 1142CF36A63C3AF9 CRC64;
MVDKKSRGHI NSDLEFKKKK HAREMKYQVL SFGLMIGLTI VAFLTVATDG VGSWFTIPFI
ILLAAIQVIF QLYYFMHMNQ KGHEAPALFL YSGVFVAFIT VLAFVTIIWW
