ID   COX4_COREF              Reviewed;         143 AA.
AC   Q8FNQ8;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Cytochrome c oxidase polypeptide 4;
DE            EC=7.1.1.9;
DE   AltName: Full=Cytochrome aa3 subunit 4;
DE   AltName: Full=Cytochrome c oxidase polypeptide IV;
GN   Name=ctaF; OrderedLocusNames=CE2086;
OS   Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189
OS   / NBRC 100395).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX   PubMed=12840036; DOI=10.1101/gr.1285603;
RA   Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S.,
RA   Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
RT   "Comparative complete genome sequence analysis of the amino acid
RT   replacements responsible for the thermostability of Corynebacterium
RT   efficiens.";
RL   Genome Res. 13:1572-1579(2003).
CC   -!- FUNCTION: Part of cytochrome c oxidase, its function is unknown.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC         [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC   -!- SUBUNIT: Associates with subunits I, II and III to form cytochrome c
CC       oxidase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit CtaF
CC       family. {ECO:0000305}.
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DR   EMBL; BA000035; BAC18896.1; -; Genomic_DNA.
DR   RefSeq; WP_006768088.1; NZ_GG700683.1.
DR   AlphaFoldDB; Q8FNQ8; -.
DR   SMR; Q8FNQ8; -.
DR   STRING; 196164.23493928; -.
DR   EnsemblBacteria; BAC18896; BAC18896; BAC18896.
DR   KEGG; cef:CE2086; -.
DR   eggNOG; ENOG5032TTI; Bacteria.
DR   HOGENOM; CLU_145919_0_0_11; -.
DR   OMA; GTYFRFV; -.
DR   OrthoDB; 1844113at2; -.
DR   Proteomes; UP000001409; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR021050; Cyt_c_oxidase_su4_actinobac.
DR   Pfam; PF12270; Cyt_c_ox_IV; 1.
DR   PIRSF; PIRSF017385; CtaF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..143
FT                   /note="Cytochrome c oxidase polypeptide 4"
FT                   /id="PRO_0000220014"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   143 AA;  15646 MW;  531814488D5F39DC CRC64;
     MKSSSKIMYG LTVFLAAMAV IYIFGTMYVD DRGSVMGLEW VGATALVLST ALTLMLGVYI
     HITERRTDVL PEDWEEAEVA DKAGTLGFFS PGSIWPAAMS GAVGLLGFGI IFMHYWLILV
     GALALTYTIA KLNFQYGVPR EKH