COX4_DICDI
ID COX4_DICDI Reviewed; 148 AA.
AC P30815; Q54U12;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Cytochrome c oxidase subunit 4, mitochondrial;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome c oxidase polypeptide IV;
DE Flags: Precursor;
GN Name=cxdA; Synonyms=cox4; ORFNames=DDB_G0281393;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX3;
RX PubMed=1653019;
RA Rizzuto R., Sandona D., Capaldi R.A., Bisson R.;
RT "Nucleotide sequence of a cDNA coding for the mitochondrial precursor
RT protein of cytochrome c oxidase subunit IV from the slime mold
RT Dictyostelium discoideum.";
RL Biochim. Biophys. Acta 1090:125-128(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: This protein is one of the nuclear-coded polypeptide chains
CC of cytochrome c oxidase, the terminal oxidase in mitochondrial electron
CC transport.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- SUBUNIT: Slime mold cytochrome c oxidase consists of at least seven
CC different polypeptides species, subunits I, II, III, IV, V, VI, and
CC VIIe/s in order of MW.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane.
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DR EMBL; X55670; CAA39205.2; -; mRNA.
DR EMBL; AAFI02000041; EAL66678.1; -; Genomic_DNA.
DR PIR; S17660; S17660.
DR RefSeq; XP_640649.1; XM_635557.1.
DR AlphaFoldDB; P30815; -.
DR PaxDb; P30815; -.
DR EnsemblProtists; EAL66678; EAL66678; DDB_G0281393.
DR GeneID; 8623033; -.
DR KEGG; ddi:DDB_G0281393; -.
DR dictyBase; DDB_G0281393; cxdA.
DR eggNOG; ENOG502RHIJ; Eukaryota.
DR HOGENOM; CLU_1762187_0_0_1; -.
DR InParanoid; P30815; -.
DR OMA; PILHICV; -.
DR PRO; PR:P30815; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Translocase.
FT TRANSIT 1..24
FT /note="Mitochondrion"
FT CHAIN 25..148
FT /note="Cytochrome c oxidase subunit 4, mitochondrial"
FT /id="PRO_0000006078"
FT CONFLICT 56
FT /note="P -> G (in Ref. 1; CAA39205)"
FT /evidence="ECO:0000305"
FT CONFLICT 136
FT /note="I -> V (in Ref. 1; CAA39205)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 148 AA; 16944 MW; 985853837B43857F CRC64;
MFALRSIRSA TKAFQTTSIV SQRGFLQTTL KNVLFPTERQ LRRQYLADNH IKVGSPEFDK
FYEDLQPSEL SKQSGLSDAL LDDPILHICV IKYNKNIVQR YNLTPEQEKD IMENYNVSAG
DPSLEQILPI PVPAHIFEEL PIVKVLNN
