COX4_MYCBO
ID COX4_MYCBO Reviewed; 139 AA.
AC P64948; A0A1R3Y0J8; Q10406; X2BKD3;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Probable cytochrome c oxidase polypeptide 4;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome aa3 subunit 4;
DE AltName: Full=Cytochrome c oxidase polypeptide IV;
GN Name=ctaF; OrderedLocusNames=BQ2027_MB2222C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- FUNCTION: Part of cytochrome c oxidase, its function is unknown.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- SUBUNIT: Associates with subunits I, II and III to form cytochrome c
CC oxidase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit CtaF
CC family. {ECO:0000305}.
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DR EMBL; LT708304; SIU00830.1; -; Genomic_DNA.
DR RefSeq; NP_855871.1; NC_002945.3.
DR RefSeq; WP_003411408.1; NC_002945.4.
DR AlphaFoldDB; P64948; -.
DR SMR; P64948; -.
DR EnsemblBacteria; SIU00830; SIU00830; BQ2027_MB2222C.
DR GeneID; 45426175; -.
DR PATRIC; fig|233413.5.peg.2438; -.
DR OMA; GTYFRFV; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR InterPro; IPR021050; Cyt_c_oxidase_su4_actinobac.
DR Pfam; PF12270; Cyt_c_ox_IV; 1.
DR PIRSF; PIRSF017385; CtaF; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Translocase; Transmembrane; Transmembrane helix.
FT CHAIN 1..139
FT /note="Probable cytochrome c oxidase polypeptide 4"
FT /id="PRO_0000220016"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 139 AA; 14865 MW; EE95E636B2179A6D CRC64;
MHIEARLFEF VAAFFVVTAV LYGVLTSMFA TGGVEWAGTT ALALTGGMAL IVATFFRFVA
RRLDSRPEDY EGAEISDGAG ELGFFSPHSW WPIMVALSGS VAAVGIALWL PWLIAAGVAF
ILASAAGLVF EYYVGPEKH
