COX4_MYCLE
ID COX4_MYCLE Reviewed; 139 AA.
AC Q9CCF0;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Probable cytochrome c oxidase polypeptide 4;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome aa3 subunit 4;
DE AltName: Full=Cytochrome c oxidase polypeptide IV;
GN Name=ctaF; OrderedLocusNames=ML0876;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: Part of cytochrome c oxidase, its function is unknown.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- SUBUNIT: Associates with subunits I, II and III to form cytochrome c
CC oxidase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit CtaF
CC family. {ECO:0000305}.
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DR EMBL; AL583920; CAC31257.1; -; Genomic_DNA.
DR PIR; F87018; F87018.
DR RefSeq; NP_301662.1; NC_002677.1.
DR RefSeq; WP_010907986.1; NC_002677.1.
DR AlphaFoldDB; Q9CCF0; -.
DR SMR; Q9CCF0; -.
DR STRING; 272631.ML0876; -.
DR EnsemblBacteria; CAC31257; CAC31257; CAC31257.
DR KEGG; mle:ML0876; -.
DR PATRIC; fig|272631.5.peg.1606; -.
DR Leproma; ML0876; -.
DR eggNOG; ENOG5032TTI; Bacteria.
DR HOGENOM; CLU_145919_0_0_11; -.
DR OMA; GTYFRFV; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR InterPro; IPR021050; Cyt_c_oxidase_su4_actinobac.
DR Pfam; PF12270; Cyt_c_ox_IV; 1.
DR PIRSF; PIRSF017385; CtaF; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..139
FT /note="Probable cytochrome c oxidase polypeptide 4"
FT /id="PRO_0000220017"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 139 AA; 14970 MW; 0CE348456D833A01 CRC64;
MHIEARLFEF VAVFFVIMAV LYGVLTSMFA TGGVDWVGTT ALALTGGLAL IVATFFRFVA
RRLDIRPEDY EGAEISDGAG ELGFFSPHSW WPVLVALSGS VAAVGIALWL PWLIVAGVVF
VLASAAGLVF EYYVGPEKH
