COX4_MYCPA
ID COX4_MYCPA Reviewed; 139 AA.
AC Q73YL6;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Probable cytochrome c oxidase polypeptide 4;
DE EC=7.1.1.9;
DE AltName: Full=Cytochrome aa3 subunit 4;
DE AltName: Full=Cytochrome c oxidase polypeptide IV;
GN Name=ctaF; OrderedLocusNames=MAP_1939c;
OS Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS (Mycobacterium paratuberculosis).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=262316;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-968 / K-10;
RX PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA Kanjilal S., Kapur V.;
RT "The complete genome sequence of Mycobacterium avium subspecies
RT paratuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC -!- FUNCTION: Part of cytochrome c oxidase, its function is unknown.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034; EC=7.1.1.9;
CC -!- SUBUNIT: Associates with subunits I, II and III to form cytochrome c
CC oxidase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit CtaF
CC family. {ECO:0000305}.
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DR EMBL; AE016958; AAS04256.1; -; Genomic_DNA.
DR RefSeq; WP_003872269.1; NC_002944.2.
DR AlphaFoldDB; Q73YL6; -.
DR SMR; Q73YL6; -.
DR STRING; 262316.MAP_1939c; -.
DR EnsemblBacteria; AAS04256; AAS04256; MAP_1939c.
DR GeneID; 66693715; -.
DR KEGG; mpa:MAP_1939c; -.
DR eggNOG; ENOG5032TTI; Bacteria.
DR HOGENOM; CLU_145919_0_0_11; -.
DR OMA; GTYFRFV; -.
DR Proteomes; UP000000580; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR InterPro; IPR021050; Cyt_c_oxidase_su4_actinobac.
DR Pfam; PF12270; Cyt_c_ox_IV; 1.
DR PIRSF; PIRSF017385; CtaF; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..139
FT /note="Probable cytochrome c oxidase polypeptide 4"
FT /id="PRO_0000220018"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 139 AA; 15076 MW; 982FDD33F94C2CBA CRC64;
MHIEARLFEF IAGFFFLTAL LYGVLTALFA TGGEEWAGTT ALALTGGLAL IVATFFRFVA
RRIDTRPEDY EGAEISDGAG ELGFFSPHSW WPILIALSGS VAAVGIALWL PWLIVAGVMF
ILSSVAGLVF EYYLGPEKH
