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COX4_MYCTU
ID   COX4_MYCTU              Reviewed;         139 AA.
AC   P9WP45; L0TBS9; P64947; Q10406;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Probable cytochrome c oxidase polypeptide 4;
DE            EC=7.1.1.9;
DE   AltName: Full=Cytochrome aa3 subunit 4;
DE   AltName: Full=Cytochrome c oxidase polypeptide IV;
GN   Name=ctaF; OrderedLocusNames=Rv2199c; ORFNames=MTCY190.10c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- FUNCTION: Part of cytochrome c oxidase, its function is unknown.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC         [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC   -!- SUBUNIT: Associates with subunits I, II and III to form cytochrome c
CC       oxidase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit CtaF
CC       family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44976.1; -; Genomic_DNA.
DR   PIR; H70784; H70784.
DR   RefSeq; NP_216715.1; NC_000962.3.
DR   RefSeq; WP_003411408.1; NZ_NVQJ01000008.1.
DR   AlphaFoldDB; P9WP45; -.
DR   SMR; P9WP45; -.
DR   STRING; 83332.Rv2199c; -.
DR   PaxDb; P9WP45; -.
DR   DNASU; 888692; -.
DR   GeneID; 45426175; -.
DR   GeneID; 888692; -.
DR   KEGG; mtu:Rv2199c; -.
DR   TubercuList; Rv2199c; -.
DR   eggNOG; ENOG5032TTI; Bacteria.
DR   OMA; GTYFRFV; -.
DR   PhylomeDB; P9WP45; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR021050; Cyt_c_oxidase_su4_actinobac.
DR   Pfam; PF12270; Cyt_c_ox_IV; 1.
DR   PIRSF; PIRSF017385; CtaF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..139
FT                   /note="Probable cytochrome c oxidase polypeptide 4"
FT                   /id="PRO_0000220019"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   139 AA;  14865 MW;  EE95E636B2179A6D CRC64;
     MHIEARLFEF VAAFFVVTAV LYGVLTSMFA TGGVEWAGTT ALALTGGMAL IVATFFRFVA
     RRLDSRPEDY EGAEISDGAG ELGFFSPHSW WPIMVALSGS VAAVGIALWL PWLIAAGVAF
     ILASAAGLVF EYYVGPEKH
 
 
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